Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation

2008 ◽  
Vol 18 (40) ◽  
pp. 4864 ◽  
Author(s):  
Gianpiero Calabrese ◽  
Ana C. N. M. Gomes ◽  
Eugen Barbu ◽  
Thomas G. Nevell ◽  
John Tsibouklis
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
In Vitro Evaluation ◽  
Lipophilic Cations ◽  
Boron Neutron Capture ◽  
Derivatives Of

Synthesis and in vitro evaluation of boronated uridine and glucose derivatives for boron neutron capture therapy.

1992 ◽  
Vol 35 (9) ◽  
pp. 1628-1633 ◽  
Author(s):  
Werner Tjarks ◽  
Abul K. M. Anisuzzaman ◽  
Liang Liu ◽  
Albert H. Soloway ◽  
Rolf F. Barth ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
In Vitro Evaluation ◽  
Boron Neutron Capture ◽  
Glucose Derivatives

Towards improved boron neutron capture therapy agents: evaluation of in vitro cellular uptake of a glutamine-functionalized carborane

2009 ◽  
Vol 14 (6) ◽  
pp. 883-890 ◽  
Author(s):  
Antonella Crivello ◽  
Carlo Nervi ◽  
Roberto Gobetto ◽  
Simonetta Geninatti Crich ◽  
Iboya Szabo ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

scholarly journals Quality Management System Program of in Vitro/in Vivo Test Facility of Boron Neutron Capture Therapy at Kartini Research Reactor

2016 ◽  
Vol 1 (2) ◽  
pp. 108
Author(s):  
Widarto Widarto ◽  
Isman Mulyadi Tri Atmoko ◽  
Gede Sutresna Wijaya
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Research Reactor ◽  
Test Facility ◽  
Neutron Capture Therapy ◽  
In Vivo Test ◽  
Boron Neutron Capture ◽  
System Program

The quality manajement system program of in vitro / in vivo test facility of  Boron Neutron Capture Therapy (BNCT) methode as quality assurance requirement for utilization of radial pearcing beamport of Kartini research have been done.  Identification and management of technical specification and parameters meassurement of to the radial piercing beamport have been determined for preparing in vitro / in vivo test facility. The parameters are epithermal neutron flux is  9,8243E+05  n cm<sup>-2</sup> s<sup>-1</sup>and  thermal neutron flux is 3,0691E+06 n cm<sup>-2</sup> s<sup>-1</sup>, radiation shielding of parafin,  dimension and size  of piercing radial and instrumentatin and control system for automatic transfer of in vitro / in vivo samplels have been documented. Management system of the documents for fullfil  basic guidance to perform working job of in vitro / in vivo at the piercing radial beamport of Kartini Research Reactor in order purpose utilization of the reactor  for safety worker of the radiation area, society  and invironment beeing safely

scholarly journals Cyclic-RGDyC functionalized liposomes for dual-targeting of tumor vasculature and cancer cells in glioblastoma: An in vitro boron neutron capture therapy study

Oncotarget ◽  
2017 ◽  
Vol 8 (22) ◽  
pp. 36614-36627 ◽  
Author(s):  
Weirong Kang ◽  
Darren Svirskis ◽  
Vijayalekshmi Sarojini ◽  
Ailsa L. McGregor ◽  
Joseph Bevitt ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Tumor Vasculature ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Dual Targeting

Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

2018 ◽  
Author(s):  
Guillaume Vares ◽  
Vincent Jallet ◽  
Yoshitaka Matsumoto ◽  
Cedric Rentier ◽  
Kentaro Takayama ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Mesoporous Silica Nanoparticles ◽  
Alpha Particles ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

AbstractTreatment resistance, relapse and metastasis remain critical issues in some challenging cancers, such as chondrosarcomas. Boron-neutron Capture Therapy (BNCT) is a targeted radiation therapy modality that relies on the ability of boron atoms to capture low energy neutrons, yielding high linear energy transfer alpha particles. We have developed an innovative boron-delivery system for BNCT, composed of multifunctional fluorescent mesoporous silica nanoparticles (B-MSNs), grafted with an activatable cell penetrating peptide (ACPP) for improved penetration in tumors and with Gadolinium for magnetic resonance imaging (MRI)in vivo. Chondrosarcoma cells were exposedin vitroto an epithermal neutron beam after B-MSNs administration. BNCT beam exposure successfully induced DNA damage and cell death, including in radio-resistant ALDH+ cancer stem cells (CSCs), suggesting that BNCT using this system might be a suitable treatment modality for chondrosarcoma or other hard-to-treat cancers.

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