scholarly journals An amphiphilic non-viral gene vector prepared by a combination of enzymatic atom transfer radical polymerization and enzymatic ring-opening polymerization

RSC Advances ◽  
2017 ◽  
Vol 7 (16) ◽  
pp. 9926-9932 ◽  
Author(s):  
Xinghuo Wang ◽  
Wenjing Yun ◽  
Wei Jiang ◽  
Ding Wang ◽  
Ling Zhang ◽  
...  

An amphiphilic non-viral gene vector (PCL-b-PGEA) was prepared by a combination of enzymatic ring-opening polymerization and enzymatic atom transfer radical polymerization for the first time and the kinetic features and gene delivery properties were investigated.

e-Polymers ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Aurore Olivier ◽  
Franck Meyer ◽  
Jean-Marie Raquez ◽  
Philippe Dubois

Abstract This paper report the synthesis of binary-patterned brushes, combining two distinctive surface initiated-polymerizations (SIP) on the basis of different propagating species: the SI Ring Opening Polymerization (ROP) of L-Lactide (LLA) and SI atom transfer radical polymerization (ATRP) of N,N’-dimethylaminoethyl methacrylate (DMAEMA) on gold surface. First of all, a careful study of surfaceinitiated ROP of L-Lactide from hydroxyl end-group of thiol monolayer on gold surface as catalyzed by metal-free catalyst was carried out. The PLLA brushes synthesis was evaluated using two types of thiol monolayer and revealed the influence of ROP initiator chain length on the final thickness of the PLLA film. Combining the soft lithographic technique, microcontact printing, and the liquid phase deposition, the deposition onto specific micro-domains of both initiators was performed. The growth of PDMAEMA brushes and PLLA brushes was conducted by successive ATRP and ROP.


2008 ◽  
Vol 40 (12) ◽  
pp. 1170-1179 ◽  
Author(s):  
Fuxiang Chang ◽  
Kazuhiro Yamabuki ◽  
Kenjiro Onimura ◽  
Tsutomu Oishi

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