scholarly journals Small-Molecule-Based Self-Assembled Ligands for G-Quadruplex DNA Surface Recognition

ACS Omega ◽  
2017 ◽  
Vol 2 (10) ◽  
pp. 6619-6627 ◽  
Author(s):  
María del C. Rivera-Sánchez ◽  
Marilyn García-Arriaga ◽  
Gerard Hobley ◽  
Ana V. Morales-de-Echegaray ◽  
José M. Rivera
Keyword(s):  
Small Molecule ◽  
Quadruplex Dna ◽  
Surface Recognition ◽  
G Quadruplex ◽  
Self Assembled

scholarly journals A site-specific self-assembled light-up rotor probe for selective recognition and stabilization of c-MYC G-quadruplex DNA

Nanoscale ◽  
2020 ◽  
Vol 12 (24) ◽  
pp. 12950-12957
Author(s):  
Marco Deiana ◽  
Karam Chand ◽  
Jan Jamroskovic ◽  
Rabindra Nath Das ◽  
Ikenna Obi ◽  
...  
Keyword(s):  
Selective Recognition ◽  
Site Specific ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Sensitivity And Selectivity ◽  
Self Assembled ◽  
A Site

A self-assembled light-up rotor probe with outstanding sensitivity and selectivity for the c-MYC promoter G-quadruplex DNA is reported.

Temperature-sensitive supramolecules self-assembled by G-quadruplex DNA

2010 ◽  
Vol 46 (1) ◽  
pp. 123-125 ◽  
Author(s):  
Hongxia Sun ◽  
Junfeng Xiang ◽  
Qiuju Zhou ◽  
Qianfan Yang ◽  
Guangzhi Xu ◽  
...  
Keyword(s):  
Temperature Sensitive ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Self Assembled

Benzothiazole hydrazones of furylbenzamides preferentially stabilize c-MYC and c-KIT1 promoter G-quadruplex DNAs

2016 ◽  
Vol 14 (24) ◽  
pp. 5779-5793 ◽  
Author(s):  
Sushree Prangya Priyadarshinee Pany ◽  
Praneeth Bommisetti ◽  
K. V. Diveshkumar ◽  
P. I. Pradeepkumar
Keyword(s):  
Small Molecule ◽  
Anticancer Agents ◽  
Next Generation ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
G Quadruplex ◽  
Small Molecule Ligands

The stabilization of G-quadruplex DNA structures by using small molecule ligands having simple structural scaffolds has the potential to be harnessed for developing next generation anticancer agents.

pH dependent multifunctional and multiply-configurable logic gate systems based on small molecule G-quadruplex DNA recognition

2013 ◽  
Vol 49 (18) ◽  
pp. 1817 ◽  
Author(s):  
Sudipta Bhowmik ◽  
Rabindra Nath Das ◽  
Bibudha Parasar ◽  
Jyotirmayee Dash
Keyword(s):  
Small Molecule ◽  
Logic Gate ◽  
Dna Recognition ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Ph Dependent

scholarly journals Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

2017 ◽  
Vol 46 (2) ◽  
pp. 329-332 ◽  
Author(s):  
O. Domarco ◽  
D. Lötsch ◽  
J. Schreiber ◽  
C. Dinhof ◽  
S. Van Schoonhoven ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Cells ◽  
Quadruplex Dna ◽  
Dna Motifs ◽  
Size Dependent ◽  
G Quadruplex ◽  
Self Assembled ◽  
Influence Gene Expression

Pt(ii) boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion and influence the expression of G-quadruplex forming genes.

scholarly journals Small-Molecule Selectively Recognizes Human Telomeric G-Quadruplex DNA and Regulates Its Conformational Switch

2009 ◽  
Vol 97 (7) ◽  
pp. 2014-2023 ◽  
Author(s):  
Mingli Chen ◽  
Guangtao Song ◽  
Chunyan Wang ◽  
Dan Hu ◽  
Jinsong Ren ◽  
...  
Keyword(s):  
Small Molecule ◽  
Conformational Switch ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals Targeted Reduction of Pathogenic Heteroplasmy Through Binding of G-Quadruplex DNA

2018 ◽  
Author(s):  
Mansur M. Naeem ◽  
Rathena Maheshan ◽  
Sheila R. Costford ◽  
Brett A. Kaufman ◽  
Neal Sondheimer
Keyword(s):  
Small Molecule ◽  
Leigh Syndrome ◽  
Quadruplex Dna ◽  
Protein Levels ◽  
Pathogenic Variants ◽  
G Quadruplex ◽  
Binding Agents ◽  
Primary Fibroblasts ◽  
Mitochondrial Heteroplasmy ◽  
Mtdna Variants

AbstractPathogenic mitochondrial DNA (mtDNA) variants are typically heteroplasmic, with coexistence of variant and wild type genomes. Because heteroplasmy dictates phenotype, the reduction of heteroplasmy is potentially therapeutic. We identified pathogenic variants that increased the potential for formation of non-canonical G-quadruplexes (GQ) within mtDNA. The Leigh Syndrome (LS)-associated mt.10191T>C variant has a high probability of local GQ formation that was enhanced by the variant. Structural studies of mt.10191C-containing oligonucleotides confirmed the formation of GQ, and its interaction with the small molecule GQ-binding agent berberine increased GQ stability. The GQ formed at mt.10191 impeded polymerase processivity, and inhibition was enhanced by the mt.10191C variant. We applied a cyclical treatment of two GQ binding compounds, berberine or RHPS4, to primary fibroblasts from LS patients with heteroplasmic mt.10191T>C mutation. This treatment induced alternating mtDNA depletion and repopulation and was effective in shifting heteroplasmy towards the nonpathogenic allele, leading to an increase in complex I protein levels. This study demonstrates the potential for using small-molecule GQ-binding agents to induce beneficial shifts in mitochondrial heteroplasmy.

Side-Chain-Dependent Binding of bis-Naphthalimide Self-Assembled Nanoparticles to G-Quadruplex DNA for Potential Anticancer Therapy

2020 ◽  
Vol 3 (2) ◽  
pp. 1339-1353
Author(s):  
Goutam Kulsi ◽  
Annie Agnes Suganya Samson ◽  
Baskaran Purushothaman ◽  
Joon Myong Song
Keyword(s):  
Anticancer Therapy ◽  
Side Chain ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Self Assembled

scholarly journals A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expression

2009 ◽  
Vol 131 (35) ◽  
pp. 12628-12633 ◽  
Author(s):  
Zoë A. E. Waller ◽  
Sven A. Sewitz ◽  
Shang-Te Danny Hsu ◽  
Shankar Balasubramanian
Keyword(s):  
Gene Expression ◽  
Small Molecule ◽  
Dna Structure ◽  
Quadruplex Dna ◽  
G Quadruplex
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