scholarly journals A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expression

2009 ◽  
Vol 131 (35) ◽  
pp. 12628-12633 ◽  
Author(s):  
Zoë A. E. Waller ◽  
Sven A. Sewitz ◽  
Shang-Te Danny Hsu ◽  
Shankar Balasubramanian
Keyword(s):  
Gene Expression ◽  
Small Molecule ◽  
Dna Structure ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals Subtle structural alterations in G-quadruplex DNA regulate site specificity of fluorescence light-up probes

2020 ◽  
Vol 48 (3) ◽  
pp. 1108-1119 ◽  
Author(s):  
Rajendra Kumar ◽  
Karam Chand ◽  
Sudipta Bhowmik ◽  
Rabindra Nath Das ◽  
Snehasish Bhattacharjee ◽  
...  
Keyword(s):  
Rational Design ◽  
Dna Structure ◽  
Biological Processes ◽  
Chemical Research ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
Future Studies ◽  
G4 Dna ◽  
G Quadruplex ◽  
Fluorescence Light

Abstract G-quadruplex (G4) DNA structures are linked to key biological processes and human diseases. Small molecules that target specific G4 DNA structures and signal their presence would therefore be of great value as chemical research tools with potential to further advance towards diagnostic and therapeutic developments. However, the development of these types of specific compounds remain as a great challenge. In here, we have developed a compound with ability to specifically signal a certain c-MYC G4 DNA structure through a fluorescence light-up mechanism. Despite the compound's two binding sites on the G4 DNA structure, only one of them result in the fluorescence light-up effect. This G-tetrad selectivity proved to originate from a difference in flexibility that affected the binding affinity and tilt the compound out of the planar conformation required for the fluorescence light-up mechanism. The intertwined relation between the presented factors is likely the reason for the lack of examples using rational design to develop compounds with turn-on emission that specifically target certain G4 DNA structures. However, this study shows that it is indeed possible to develop such compounds and present insights into the molecular details of specific G4 DNA recognition and signaling to advance future studies of G4 biology.

Antitumor substitution-inert polynuclear platinum complexes stabilize G-quadruplex DNA and suppress G-quadruplex-mediated gene expression

2021 ◽  
Author(s):  
Jaroslav Malina ◽  
Hana Kostrhunova ◽  
Nicholas Patrick Farrell ◽  
Viktor Brabec
Keyword(s):  
Gene Expression ◽  
Drug Targets ◽  
Platinum Complexes ◽  
Anticancer Therapy ◽  
Promoter Regions ◽  
Quadruplex Dna ◽  
G Quadruplex

DNA G-quadruplex (G4) structures formed in the telomeric and promoter regions represent attractive drug targets for anticancer therapy. Thus, much effort has been devoted to the development of a variety...

scholarly journals A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation

2015 ◽  
Vol 6 (1) ◽  
pp. e1610-e1610 ◽  
Author(s):  
X Gao ◽  
W Ma ◽  
J Nie ◽  
C Zhang ◽  
J Zhang ◽  
...  
Keyword(s):  
Dna Structure ◽  
Quadruplex Dna ◽  
G Quadruplex

Benzothiazole hydrazones of furylbenzamides preferentially stabilize c-MYC and c-KIT1 promoter G-quadruplex DNAs

2016 ◽  
Vol 14 (24) ◽  
pp. 5779-5793 ◽  
Author(s):  
Sushree Prangya Priyadarshinee Pany ◽  
Praneeth Bommisetti ◽  
K. V. Diveshkumar ◽  
P. I. Pradeepkumar
Keyword(s):  
Small Molecule ◽  
Anticancer Agents ◽  
Next Generation ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
G Quadruplex ◽  
Small Molecule Ligands

The stabilization of G-quadruplex DNA structures by using small molecule ligands having simple structural scaffolds has the potential to be harnessed for developing next generation anticancer agents.

pH dependent multifunctional and multiply-configurable logic gate systems based on small molecule G-quadruplex DNA recognition

2013 ◽  
Vol 49 (18) ◽  
pp. 1817 ◽  
Author(s):  
Sudipta Bhowmik ◽  
Rabindra Nath Das ◽  
Bibudha Parasar ◽  
Jyotirmayee Dash
Keyword(s):  
Small Molecule ◽  
Logic Gate ◽  
Dna Recognition ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Ph Dependent

scholarly journals Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

2017 ◽  
Vol 46 (2) ◽  
pp. 329-332 ◽  
Author(s):  
O. Domarco ◽  
D. Lötsch ◽  
J. Schreiber ◽  
C. Dinhof ◽  
S. Van Schoonhoven ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Cells ◽  
Quadruplex Dna ◽  
Dna Motifs ◽  
Size Dependent ◽  
G Quadruplex ◽  
Self Assembled ◽  
Influence Gene Expression

Pt(ii) boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion and influence the expression of G-quadruplex forming genes.

scholarly journals Metadynamics Study of the Free Energy Surface of a G-Quadruplex DNA Structure

2010 ◽  
Vol 98 (3) ◽  
pp. 265a
Author(s):  
Juan-Antonio Mondragón-Sánchez ◽  
Edmundo Mendieta-Fernández ◽  
Ramon Garduño-Juárez ◽  
Gilberto Sánchez-González
Keyword(s):  
Free Energy ◽  
Energy Surface ◽  
Dna Structure ◽  
Free Energy Surface ◽  
Quadruplex Dna ◽  
G Quadruplex
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