scholarly journals Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

2017 ◽  
Vol 46 (2) ◽  
pp. 329-332 ◽  
Author(s):  
O. Domarco ◽  
D. Lötsch ◽  
J. Schreiber ◽  
C. Dinhof ◽  
S. Van Schoonhoven ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Cells ◽  
Quadruplex Dna ◽  
Dna Motifs ◽  
Size Dependent ◽  
G Quadruplex ◽  
Self Assembled ◽  
Influence Gene Expression

Pt(ii) boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion and influence the expression of G-quadruplex forming genes.

scholarly journals Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

2014 ◽  
Vol 111 (27) ◽  
pp. 9905-9910 ◽  
Author(s):  
Giang Huong Nguyen ◽  
Weiliang Tang ◽  
Ana I. Robles ◽  
Richard P. Beyer ◽  
Lucas T. Gray ◽  
...  
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Quadruplex Dna ◽  
Dna Motifs ◽  
Blm Helicase ◽  
G Quadruplex

Antitumor substitution-inert polynuclear platinum complexes stabilize G-quadruplex DNA and suppress G-quadruplex-mediated gene expression

2021 ◽  
Author(s):  
Jaroslav Malina ◽  
Hana Kostrhunova ◽  
Nicholas Patrick Farrell ◽  
Viktor Brabec
Keyword(s):  
Gene Expression ◽  
Drug Targets ◽  
Platinum Complexes ◽  
Anticancer Therapy ◽  
Promoter Regions ◽  
Quadruplex Dna ◽  
G Quadruplex

DNA G-quadruplex (G4) structures formed in the telomeric and promoter regions represent attractive drug targets for anticancer therapy. Thus, much effort has been devoted to the development of a variety...

scholarly journals A site-specific self-assembled light-up rotor probe for selective recognition and stabilization of c-MYC G-quadruplex DNA

Nanoscale ◽  
2020 ◽  
Vol 12 (24) ◽  
pp. 12950-12957
Author(s):  
Marco Deiana ◽  
Karam Chand ◽  
Jan Jamroskovic ◽  
Rabindra Nath Das ◽  
Ikenna Obi ◽  
...  
Keyword(s):  
Selective Recognition ◽  
Site Specific ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Sensitivity And Selectivity ◽  
Self Assembled ◽  
A Site

A self-assembled light-up rotor probe with outstanding sensitivity and selectivity for the c-MYC promoter G-quadruplex DNA is reported.

Temperature-sensitive supramolecules self-assembled by G-quadruplex DNA

2010 ◽  
Vol 46 (1) ◽  
pp. 123-125 ◽  
Author(s):  
Hongxia Sun ◽  
Junfeng Xiang ◽  
Qiuju Zhou ◽  
Qianfan Yang ◽  
Guangzhi Xu ◽  
...  
Keyword(s):  
Temperature Sensitive ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Self Assembled

The biological activity of G-quadruplex DNA binding papaverine-derived ligand in breast cancer cells

2008 ◽  
Vol 27 (4) ◽  
pp. 289-296 ◽  
Author(s):  
Blazej Rubis ◽  
Mariusz Kaczmarek ◽  
Natalia Szymanowska ◽  
Elzbieta Galezowska ◽  
Andrzej Czyrski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Dna Binding ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals Targeting G-quadruplex DNA with synthetic dendritic peptide: modulation of the proliferation of human cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (44) ◽  
pp. 26388-26396
Author(s):  
Soumi Biswas ◽  
Satyabrata Samui ◽  
Apurba K. Das ◽  
Sanjeev Pasadi ◽  
K. Muniyappa ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Quadruplex Dna ◽  
Human Cancer Cells ◽  
G4 Dna ◽  
G Quadruplex ◽  
Peptide Targeting

A synthetic dendritic peptide, targeting human telomeric G4 DNA, inhibits the telomerase and lessens the proliferation of human cancer cells.

scholarly journals Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Patrick Merle ◽  
Marine Gueugneau ◽  
Marie-Paule Teulade-Fichou ◽  
Mélanie Müller-Barthélémy ◽  
Simon Amiard ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Binding ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Human Glioblastoma ◽  
Quadruplex Dna ◽  
Highly Efficient ◽  
G Quadruplex
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