A propeller-like small molecule as a novel G-quadruplex DNA binder: The study of fluorescent sensing property and preferential interactions with human telo21 structure

2018 ◽  
Vol 93 (6) ◽  
pp. 979-985 ◽  
Author(s):  
Ning Sun ◽  
Dongli Li ◽  
Jinqiang Hou ◽  
Wei Long ◽  
Qi Guo ◽  
...  
Keyword(s):  
Small Molecule ◽  
Quadruplex Dna ◽  
Fluorescent Sensing ◽  
G Quadruplex ◽  
Preferential Interactions

Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA

2009 ◽  
Vol 48 (12) ◽  
pp. 2188-2191 ◽  
Author(s):  
Peng Yang ◽  
Anne De Cian ◽  
Marie-Paule Teulade-Fichou ◽  
Jean-Louis Mergny ◽  
David Monchaud
Keyword(s):  
Thiazole Orange ◽  
Quadruplex Dna ◽  
Fluorescent Sensing ◽  
G Quadruplex

Benzothiazole hydrazones of furylbenzamides preferentially stabilize c-MYC and c-KIT1 promoter G-quadruplex DNAs

2016 ◽  
Vol 14 (24) ◽  
pp. 5779-5793 ◽  
Author(s):  
Sushree Prangya Priyadarshinee Pany ◽  
Praneeth Bommisetti ◽  
K. V. Diveshkumar ◽  
P. I. Pradeepkumar
Keyword(s):  
Small Molecule ◽  
Anticancer Agents ◽  
Next Generation ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
G Quadruplex ◽  
Small Molecule Ligands

The stabilization of G-quadruplex DNA structures by using small molecule ligands having simple structural scaffolds has the potential to be harnessed for developing next generation anticancer agents.

pH dependent multifunctional and multiply-configurable logic gate systems based on small molecule G-quadruplex DNA recognition

2013 ◽  
Vol 49 (18) ◽  
pp. 1817 ◽  
Author(s):  
Sudipta Bhowmik ◽  
Rabindra Nath Das ◽  
Bibudha Parasar ◽  
Jyotirmayee Dash
Keyword(s):  
Small Molecule ◽  
Logic Gate ◽  
Dna Recognition ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Ph Dependent

Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA

2009 ◽  
Vol 121 (12) ◽  
pp. 2222-2225 ◽  
Author(s):  
Peng Yang ◽  
Anne De Cian ◽  
Marie-Paule Teulade-Fichou ◽  
Jean-Louis Mergny ◽  
David Monchaud
Keyword(s):  
Thiazole Orange ◽  
Quadruplex Dna ◽  
Fluorescent Sensing ◽  
G Quadruplex

scholarly journals Small-Molecule-Based Self-Assembled Ligands for G-Quadruplex DNA Surface Recognition

ACS Omega ◽  
2017 ◽  
Vol 2 (10) ◽  
pp. 6619-6627 ◽  
Author(s):  
María del C. Rivera-Sánchez ◽  
Marilyn García-Arriaga ◽  
Gerard Hobley ◽  
Ana V. Morales-de-Echegaray ◽  
José M. Rivera
Keyword(s):  
Small Molecule ◽  
Quadruplex Dna ◽  
Surface Recognition ◽  
G Quadruplex ◽  
Self Assembled

scholarly journals Small-Molecule Selectively Recognizes Human Telomeric G-Quadruplex DNA and Regulates Its Conformational Switch

2009 ◽  
Vol 97 (7) ◽  
pp. 2014-2023 ◽  
Author(s):  
Mingli Chen ◽  
Guangtao Song ◽  
Chunyan Wang ◽  
Dan Hu ◽  
Jinsong Ren ◽  
...  
Keyword(s):  
Small Molecule ◽  
Conformational Switch ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals Targeted Reduction of Pathogenic Heteroplasmy Through Binding of G-Quadruplex DNA

2018 ◽  
Author(s):  
Mansur M. Naeem ◽  
Rathena Maheshan ◽  
Sheila R. Costford ◽  
Brett A. Kaufman ◽  
Neal Sondheimer
Keyword(s):  
Small Molecule ◽  
Leigh Syndrome ◽  
Quadruplex Dna ◽  
Protein Levels ◽  
Pathogenic Variants ◽  
G Quadruplex ◽  
Binding Agents ◽  
Primary Fibroblasts ◽  
Mitochondrial Heteroplasmy ◽  
Mtdna Variants

AbstractPathogenic mitochondrial DNA (mtDNA) variants are typically heteroplasmic, with coexistence of variant and wild type genomes. Because heteroplasmy dictates phenotype, the reduction of heteroplasmy is potentially therapeutic. We identified pathogenic variants that increased the potential for formation of non-canonical G-quadruplexes (GQ) within mtDNA. The Leigh Syndrome (LS)-associated mt.10191T>C variant has a high probability of local GQ formation that was enhanced by the variant. Structural studies of mt.10191C-containing oligonucleotides confirmed the formation of GQ, and its interaction with the small molecule GQ-binding agent berberine increased GQ stability. The GQ formed at mt.10191 impeded polymerase processivity, and inhibition was enhanced by the mt.10191C variant. We applied a cyclical treatment of two GQ binding compounds, berberine or RHPS4, to primary fibroblasts from LS patients with heteroplasmic mt.10191T>C mutation. This treatment induced alternating mtDNA depletion and repopulation and was effective in shifting heteroplasmy towards the nonpathogenic allele, leading to an increase in complex I protein levels. This study demonstrates the potential for using small-molecule GQ-binding agents to induce beneficial shifts in mitochondrial heteroplasmy.

scholarly journals A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expression

2009 ◽  
Vol 131 (35) ◽  
pp. 12628-12633 ◽  
Author(s):  
Zoë A. E. Waller ◽  
Sven A. Sewitz ◽  
Shang-Te Danny Hsu ◽  
Shankar Balasubramanian
Keyword(s):  
Gene Expression ◽  
Small Molecule ◽  
Dna Structure ◽  
Quadruplex Dna ◽  
G Quadruplex

Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators

2020 ◽  
Vol 27 (1) ◽  
pp. 154-169 ◽  
Author(s):  
Claudiu N. Lungu ◽  
Bogdan Ionel Bratanovici ◽  
Maria Mirabela Grigore ◽  
Vasilichia Antoci ◽  
Ionel I. Mangalagiu
Keyword(s):  
Experimental Data ◽  
Antimicrobial Properties ◽  
Qsar Model ◽  
Therapeutic Effectiveness ◽  
Computational Results ◽  
Pyridine Derivatives ◽  
Quadruplex Dna ◽  
Dna Intercalators ◽  
Structure Activity ◽  
G Quadruplex

Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was developed in order to further investigate the structure-activity relationship. Results showed that synthesized compounds have antitumoral and antimicrobial properties. Computational results agreed with the experimental data.

Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy

2017 ◽  
Vol 22 (44) ◽  
pp. 6612-6624 ◽  
Author(s):  
Graziella Cimino-Reale ◽  
Nadia Zaffaroni ◽  
Marco Folini
Keyword(s):  
Anticancer Therapy ◽  
Quadruplex Dna ◽  
G Quadruplex
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