scholarly journals Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

2015 ◽  
Vol 10 (9) ◽  
pp. 1977-1988 ◽  
Author(s):  
Leslie O. Ofori ◽  
Nimali P. Withana ◽  
Tyler R. Prestwood ◽  
Martijn Verdoes ◽  
Jennifer J. Brady ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Optical Contrast ◽  
Guided Surgery ◽  
Optical Contrast Agents ◽  
Fluorescence Guided Surgery

Cyanine Dyes as Optical Contrast Agents for Ophthalmological Surgery

2011 ◽  
Vol 54 (11) ◽  
pp. 3903-3925 ◽  
Author(s):  
Heinz Langhals ◽  
Ana Varja ◽  
Peter Laubichler ◽  
Marcus Kernt ◽  
Kirsten Eibl ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Cyanine Dyes ◽  
Optical Contrast ◽  
Optical Contrast Agents

Peptide-based optical contrast agents for targeting of intestinal malignancies

2007 ◽  
Author(s):  
Niels Röckendorf ◽  
Jürgen Helfmann ◽  
Naho Fujimoto ◽  
Katrin Wehry ◽  
Mario Bürger ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Optical Contrast ◽  
Optical Contrast Agents

Peptide-based optical contrast agents for targeting of intestinal malignancies

2007 ◽  
Author(s):  
Niels Röckendorf ◽  
Jürgen Helfmann ◽  
Naho Fujimoto ◽  
Katrin Wehry ◽  
Mario Bürger ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Optical Contrast ◽  
Optical Contrast Agents

scholarly journals Multivariate AND-gate substrate probes as enhanced contrast agents for fluorescence-guided surgery

2019 ◽  
Author(s):  
John C. Widen ◽  
Martina Tholen ◽  
Joshua J. Yim ◽  
Alexander Antaris ◽  
Kerriann M. Casey ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Therapy Response ◽  
Response Monitoring ◽  
Multiple Tumor ◽  
Normal Tissues ◽  
Sequential Processing ◽  
Guided Surgery ◽  
Enhanced Sensitivity ◽  
Optical Contrast Agents ◽  
Imaging Probes

AbstractThe greatest challenges for surgical management of cancer are precisely locating lesions and clearly defining the margins between tumors and normal tissues. This is confounded by the characteristics of the tissue where the tumor is located as well as its propensity to form irregular boundaries with healthy tissues. To address these issues, molecularly targeted optical contrast agents have been developed to define margins in real-time during surgery1,2. However, selectivity of a contrast agent is often limited by expression of a target enzyme or receptor in both tumor and healthy tissues. Here we introduce a concept of multivariate ‘AND-gate’ optical imaging probes that require sequential processing by multiple tumor-specific enzymes to produce a fluorescent signal. This results in dramatically improved specificity as well as overall enhanced sensitivity. This general approach has the potential to be broadly applied to selectively target complex patterns of enzyme activities in diverse disease tissues for detection, treatment and therapy response monitoring.

Guiding of HIFU beams towards optical contrast agents by time‐reversal of photoacoustic waves

2008 ◽  
Vol 123 (5) ◽  
pp. 3430-3430
Author(s):  
Emmanuel Bossy ◽  
Jean‐François Aubry ◽  
Arik R. Funke ◽  
Mathias Fink ◽  
Albert‐Claude Boccara
Keyword(s):  
Contrast Agents ◽  
Time Reversal ◽  
Optical Contrast ◽  
Optical Contrast Agents
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