Cyanine Dyes as Optical Contrast Agents for Ophthalmological Surgery

2011 ◽  
Vol 54 (11) ◽  
pp. 3903-3925 ◽  
Author(s):  
Heinz Langhals ◽  
Ana Varja ◽  
Peter Laubichler ◽  
Marcus Kernt ◽  
Kirsten Eibl ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Cyanine Dyes ◽  
Optical Contrast ◽  
Optical Contrast Agents

Peptide-based optical contrast agents for targeting of intestinal malignancies

2007 ◽  
Author(s):  
Niels Röckendorf ◽  
Jürgen Helfmann ◽  
Naho Fujimoto ◽  
Katrin Wehry ◽  
Mario Bürger ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Optical Contrast ◽  
Optical Contrast Agents

Peptide-based optical contrast agents for targeting of intestinal malignancies

2007 ◽  
Author(s):  
Niels Röckendorf ◽  
Jürgen Helfmann ◽  
Naho Fujimoto ◽  
Katrin Wehry ◽  
Mario Bürger ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Optical Contrast ◽  
Optical Contrast Agents

Guiding of HIFU beams towards optical contrast agents by time‐reversal of photoacoustic waves

2008 ◽  
Vol 123 (5) ◽  
pp. 3430-3430
Author(s):  
Emmanuel Bossy ◽  
Jean‐François Aubry ◽  
Arik R. Funke ◽  
Mathias Fink ◽  
Albert‐Claude Boccara
Keyword(s):  
Contrast Agents ◽  
Time Reversal ◽  
Optical Contrast ◽  
Optical Contrast Agents

scholarly journals Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Homa Assadi ◽  
Raffi Karshafian ◽  
Alexandre Douplik
Keyword(s):  
Contrast Agents ◽  
Volume Concentration ◽  
Optical Scattering ◽  
Imaging Systems ◽  
Integrating Sphere ◽  
Optical Contrast ◽  
Optical Contrast Agents ◽  
Diagnostic Modalities ◽  
Total Transmittance ◽  
Potential Use

In imaging, contrast agents are utilized to enhance sensitivity and specificity of diagnostic modalities. In ultrasound imaging, microbubbles (MBs)—a gas-core shell-encapsulated agent—are used clinically as contrast agents. The working hypothesis of this study is that microbubbles can be employed as an intravascular contrast agent in optical imaging systems. In this work, the interaction of light and microbubbles in a turbid medium (intralipid) was investigated, particularly, the effect of MBs on the reduced scattering and absorption coefficients. Diffuse reflectance (DR) and total transmittance (TT) measurements of highly scattering intralipid suspension (0.5–5%) were measured using spectroscopic integrating sphere system in the absence and presence of Definity microbubbles. The optical properties were computed using the inverse adding doubling (IAD) software. The presence of microbubbles increased DR and decreased TT of intralipid phantoms. In the presence of MBs (0.5% volume concentration), the reflectance of the intralipid phantom increased from 35% to 100%. The reduced scattering coefficient increased significantly (30%) indicating potential use of MBs as optical contrast agents in light based modalities.

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