scholarly journals Construction of CNA35 Collagen-Targeted Phase-Changeable Nanoagents for Low-Intensity Focused Ultrasound-Triggered Ultrasound Molecular Imaging of Myocardial Fibrosis in Rabbits

2019 ◽  
Vol 11 (26) ◽  
pp. 23006-23017
Author(s):  
Qin Zhou ◽  
Yalin Zeng ◽  
Qingsong Xiong ◽  
Shigen Zhong ◽  
Pan Li ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Myocardial Fibrosis ◽  
Focused Ultrasound ◽  
Low Intensity ◽  
Ultrasound Molecular Imaging

Low intensity focused ultrasound (LIFU) triggered drug release from cetuximab-conjugated phase-changeable nanoparticles for precision theranostics against anaplastic thyroid carcinoma

2019 ◽  
Vol 7 (1) ◽  
pp. 196-210 ◽  
Author(s):  
Yang Wang ◽  
Guoqing Sui ◽  
Dengke Teng ◽  
Qimeihui Wang ◽  
Jia Qu ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Drug Release ◽  
Thyroid Carcinoma ◽  
Focused Ultrasound ◽  
Anaplastic Thyroid Carcinoma ◽  
Antitumor Therapy ◽  
Low Intensity ◽  
Targeted Ultrasound ◽  
Triggered Drug Release ◽  
Ultrasound Molecular Imaging

This study provides an efficient theranostic strategy for concurrent targeted ultrasound molecular imaging and effective synergistic antitumor therapy.

Low-intensity focused ultrasound (LIFU)-activated nanodroplets as a theranostic agent for noninvasive cancer molecular imaging and drug delivery

2018 ◽  
Vol 6 (11) ◽  
pp. 2838-2849 ◽  
Author(s):  
Jianxin Liu ◽  
Fenfen Xu ◽  
Ju Huang ◽  
Jinshun Xu ◽  
Yang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Focused Ultrasound ◽  
Research Field ◽  
Low Intensity ◽  
Theranostic Agent ◽  
Therapeutic Drugs ◽  
Tumor Research

Theranostics is a new trend in the tumor research field, which involves the integration of diagnostic and therapeutic functions using imageable nanoparticles coupled with therapeutic drugs.

Ultrasound molecular imaging-guided tumor gene therapy through dual-targeted cationic microbubbles

2021 ◽  
Vol 9 (7) ◽  
pp. 2454-2466
Author(s):  
Yingying Liu ◽  
Yuli Zhou ◽  
Jinfeng Xu ◽  
Hui Luo ◽  
Yao Zhu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Molecular Imaging ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Tumor Gene Therapy ◽  
Ultrasound Molecular Imaging ◽  
Tumor Gene

A novel dual-targeted cationic microbubbles help to improve gene transfection efficiency.

Effects of External Low Intensity Focused Ultrasound on Inflammatory Markers in Neuropathic Pain

2021 ◽  
pp. 135977
Author(s):  
Abigail Hellman ◽  
Alicia Clum ◽  
Teresa Maietta ◽  
Adithya Srikanthan ◽  
Vraj Patel ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Inflammatory Markers ◽  
Focused Ultrasound ◽  
Low Intensity

scholarly journals The Impact of Lipid Handling and Phase Distribution on the Acoustic Behavior of Microbubbles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 119
Author(s):  
Simone A.G. Langeveld ◽  
Inés Beekers ◽  
Gonzalo Collado-Lara ◽  
Antonius F. W. van der Steen ◽  
Nico de Jong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
High Speed ◽  
Phase Distribution ◽  
Direct Method ◽  
Ultrasound Contrast Agents ◽  
Lipid Phase ◽  
Acoustic Behavior ◽  
Ultrasound Molecular Imaging ◽  
The Impact

Phospholipid-coated microbubbles are ultrasound contrast agents that can be employed for ultrasound molecular imaging and drug delivery. For safe and effective implementation, microbubbles must respond uniformly and predictably to ultrasound. Therefore, we investigated how lipid handling and phase distribution affected the variability in the acoustic behavior of microbubbles. Cholesterol was used to modify the lateral molecular packing of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)-based microbubbles. To assess the effect of lipid handling, microbubbles were produced by a direct method, i.e., lipids directly dispersed in an aqueous medium or indirect method, i.e., lipids first dissolved in an organic solvent. The lipid phase and ligand distribution in the microbubble coating were investigated using confocal microscopy, and the acoustic response was recorded with the Brandaris 128 ultra-high-speed camera. In microbubbles with 12 mol% cholesterol, the lipids were miscible and all in the same phase, which resulted in more buckle formation, lower shell elasticity and higher shell viscosity. Indirect DSPC microbubbles had a more uniform response to ultrasound than direct DSPC and indirect DSPC-cholesterol microbubbles. The difference in lipid handling between direct and indirect DSPC microbubbles significantly affected the acoustic behavior. Indirect DSPC microbubbles are the most promising candidate for ultrasound molecular imaging and drug delivery applications.

scholarly journals Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

2018 ◽  
Vol 128 (3) ◽  
pp. 875-884 ◽  
Author(s):  
Robert F. Dallapiazza ◽  
Kelsie F. Timbie ◽  
Stephen Holmberg ◽  
Jeremy Gatesman ◽  
M. Beatriz Lopes ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Thalamic Nucleus ◽  
Acoustic Energy ◽  
Similar Degree ◽  
Thalamic Nuclei ◽  
Low Intensity ◽  
Tissue Heating ◽  
The Central Nervous System ◽  
Selective Mapping ◽  
Noninvasive Neuromodulation

OBJECTIVEUltrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage. The objective of this study was to demonstrate the effects of low-intensity focused ultrasound (LIFU) for neuromodulation and selective mapping in the thalamus of a large-brain animal.METHODSTen Yorkshire swine (Sus scrofa domesticus) were used in this study. In the first neuromodulation experiment, the lemniscal sensory thalamus was stereotactically targeted with LIFU, and somatosensory evoked potentials (SSEPs) were monitored. In a second mapping experiment, the ventromedial and ventroposterolateral sensory thalamic nuclei were alternately targeted with LIFU, while both trigeminal and tibial evoked SSEPs were recorded. Temperature at the acoustic focus was assessed using MR thermography. At the end of the experiments, all tissues were assessed histologically for damage.RESULTSLIFU targeted to the ventroposterolateral thalamic nucleus suppressed SSEP amplitude to 71.6% ± 11.4% (mean ± SD) compared with baseline recordings. Second, we found a similar degree of inhibition with a high spatial resolution (∼ 2 mm) since adjacent thalamic nuclei could be selectively inhibited. The ventromedial thalamic nucleus could be inhibited without affecting the ventrolateral nucleus. During MR thermography imaging, there was no observed tissue heating during LIFU sonications and no histological evidence of tissue damage.CONCLUSIONSThese results suggest that LIFU can be safely used to modulate neuronal circuits in the central nervous system and that noninvasive brain mapping with focused ultrasound may be feasible in humans.

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