scholarly journals Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging

2017 ◽  
Vol Volume 12 ◽  
pp. 911-923 ◽  
Author(s):  
Jianxin Liu ◽  
Tingting Shang ◽  
Fengjuan Wang ◽  
Yang Cao ◽  
Lan Hao ◽  
...  
Keyword(s):  
Phase Transition ◽  
Molecular Imaging ◽  
Focused Ultrasound ◽  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Low Intensity ◽  
Ultrasound Molecular Imaging

Low intensity focused ultrasound (LIFU) triggered drug release from cetuximab-conjugated phase-changeable nanoparticles for precision theranostics against anaplastic thyroid carcinoma

2019 ◽  
Vol 7 (1) ◽  
pp. 196-210 ◽  
Author(s):  
Yang Wang ◽  
Guoqing Sui ◽  
Dengke Teng ◽  
Qimeihui Wang ◽  
Jia Qu ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Drug Release ◽  
Thyroid Carcinoma ◽  
Focused Ultrasound ◽  
Anaplastic Thyroid Carcinoma ◽  
Antitumor Therapy ◽  
Low Intensity ◽  
Targeted Ultrasound ◽  
Triggered Drug Release ◽  
Ultrasound Molecular Imaging

This study provides an efficient theranostic strategy for concurrent targeted ultrasound molecular imaging and effective synergistic antitumor therapy.

WE-E-304A-05: Acoustic Droplet Vaporization for Enhancement of High Intensity Focused Ultrasound Thermal Ablation

2009 ◽  
Vol 36 (6Part26) ◽  
pp. 2786-2787
Author(s):  
M Zhang ◽  
KJ Haworth ◽  
SD Swanson ◽  
ML Fabiilli ◽  
OD Kripfgans ◽  
...  
Keyword(s):  
High Intensity ◽  
Thermal Ablation ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization

scholarly journals Acoustic Droplet Vaporization in Biology and Medicine

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Chung-Yin Lin ◽  
William G. Pitt
Keyword(s):  
Drug Delivery ◽  
Contrast Agent ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Superheated Liquid ◽  
Clinical Use ◽  
Vessel Occlusion ◽  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Preclinical Trials

This paper reviews the literature regarding the use of acoustic droplet vaporization (ADV) in clinical applications of imaging, embolic therapy, and therapeutic delivery. ADV is a physical process in which the pressure waves of ultrasound induce a phase transition that causes superheated liquid nanodroplets to form gas bubbles. The bubbles provide ultrasonic imaging contrast and other functions. ADV of perfluoropentane was used extensively in imaging for preclinical trials in the 1990s, but its use declined rapidly with the advent of other imaging agents. In the last decade, ADV was proposed and explored for embolic occlusion therapy, drug delivery, aberration correction, and high intensity focused ultrasound (HIFU) sensitization. Vessel occlusion via ADV has been explored in rodents and dogs and may be approaching clinical use. ADV for drug delivery is still in preclinical stages with initial applications to treat tumors in mice. Other techniques are still in preclinical studies but have potential for clinical use in specialty applications. Overall, ADV has a bright future in clinical application because the small size of nanodroplets greatly reduces the rate of clearance compared to larger contrast agent bubbles and yet provides the advantages of ultrasonographic contrast, acoustic cavitation, and nontoxicity of conventional perfluorocarbon contrast agent bubbles.

scholarly journals Acoustic Droplet Vaporization for Enhancement of Thermal Ablation by High Intensity Focused Ultrasound

2011 ◽  
Vol 18 (9) ◽  
pp. 1123-1132 ◽  
Author(s):  
Man Zhang ◽  
Mario L. Fabiilli ◽  
Kevin J. Haworth ◽  
Frederic Padilla ◽  
Scott D. Swanson ◽  
...  
Keyword(s):  
High Intensity ◽  
Thermal Ablation ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization
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