Ultrasound molecular imaging-guided tumor gene therapy through dual-targeted cationic microbubbles

2021 ◽  
Vol 9 (7) ◽  
pp. 2454-2466
Author(s):  
Yingying Liu ◽  
Yuli Zhou ◽  
Jinfeng Xu ◽  
Hui Luo ◽  
Yao Zhu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Molecular Imaging ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Tumor Gene Therapy ◽  
Ultrasound Molecular Imaging ◽  
Tumor Gene

A novel dual-targeted cationic microbubbles help to improve gene transfection efficiency.

scholarly journals Molecular Imaging of Gene Expression and Efficacy following Adenoviral-Mediated Brain Tumor Gene Therapy

2002 ◽  
Vol 1 (1) ◽  
pp. 43-55 ◽  
Author(s):  
Alnawaz Rehemtulla ◽  
Daniel E. Hall ◽  
Lauren D. Stegman ◽  
Uttara Prasad ◽  
Grace Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Therapy ◽  
Brain Tumor ◽  
Molecular Imaging ◽  
Tumor Gene Therapy ◽  
Tumor Gene

A nanogel with passive targeting function and adjustable polyplex surface properties for efficient anti-tumor gene therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (87) ◽  
pp. 84445-84456 ◽  
Author(s):  
Haizhou Zhang ◽  
Qingbao Li ◽  
Yingying Zhang ◽  
Yu Xia ◽  
Liang Yun ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Surface Properties ◽  
Gene Transfection ◽  
Tumor Inhibition ◽  
Passive Targeting ◽  
Cellular Targeting ◽  
Tumor Gene Therapy ◽  
Dual Responsive ◽  
Tumor Gene

A dual responsive nanogel with tuneable polyplex properties was finely prepared. Its highin vivo/vitrogene transfection ability and passive cellular targeting function strongly promoted intratumor accumulation and tumor inhibition.

scholarly journals Lipoic Acid-Modified Oligoethyleneimine-Mediated miR-34a Delivery to Achieve the Anti-Tumor Efficacy

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4827
Author(s):  
Yu Huang ◽  
Longxiang Wang ◽  
Yingxuan Chen ◽  
Haobo Han ◽  
Quanshun Li
Keyword(s):  
Gene Therapy ◽  
Lipoic Acid ◽  
Laser Scanning ◽  
Transfection Efficiency ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Tumor Gene Therapy ◽  
Cervical Carcinoma Cell Line ◽  
Cell Line Hela ◽  
Tumor Gene

MiR-34a, an important tumor suppressor, has been demonstrated to possess great potential in tumor gene therapy. To achieve the upregulation of miR-34a expression level, an oligoethyleneimine (OEI) derivative was constructed and employed as the carrier through the modification with lipoic acid (LA), namely LA-OEI. In contrast to OEI, the derivative LA-OEI exhibited superior transfection efficiency measured by confocal laser scanning microscopy and flow cytometry, owing to rapid cargo release in the disulfide bond-based reduction sensitive pattern. The anti-proliferation and anti-migration effects were tested after the miR-34a transfection to evaluate the anti-tumor response, using human cervical carcinoma cell line HeLa as a model. The delivery of LA-OEI/miR-34a nanoparticles could achieve obvious anti-proliferative effect caused by the induction of cell apoptosis and cell cycle arrest at G1 phase. In addition, it could inhibit the migration of tumor cells via the downregulation of MMP-9 and Notch-1 level. Overall, the LA-OEI-mediated miR-34a delivery was potential to be used as an effective way in the tumor gene therapy.

Non-Viral Vectors for Gene Delivery

2018 ◽  
Vol 9 (1) ◽  
pp. 4-11 ◽  
Author(s):  
Aparna Bansal ◽  
Himanshu
Keyword(s):  
Gene Therapy ◽  
Viral Vectors ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Expression System ◽  
Target Cells ◽  
Specific Expression ◽  
Naked Dna

Introduction: Gene therapy has emerged out as a promising therapeutic pave for the treatment of genetic and acquired diseases. Gene transfection into target cells using naked DNA is a simple and safe approach which has been further improved by combining vectors or gene carriers. Both viral and non-viral approaches have achieved a milestone to establish this technique, but non-viral approaches have attained a significant attention because of their favourable properties like less immunotoxicity and biosafety, easy to produce with versatile surface modifications, etc. Literature is rich in evidences which revealed that undoubtedly, non–viral vectors have acquired a unique place in gene therapy but still there are number of challenges which are to be overcome to increase their effectiveness and prove them ideal gene vectors. Conclusion: To date, tissue specific expression, long lasting gene expression system, enhanced gene transfection efficiency has been achieved with improvement in delivery methods using non-viral vectors. This review mainly summarizes the various physical and chemical methods for gene transfer in vitro and in vivo.

Covalent organic framework nanoparticles for anti-tumor gene therapy

2021 ◽  
Author(s):  
Kai Hao ◽  
Zhaopei Guo ◽  
Lin Lin ◽  
Pingjie Sun ◽  
Yanhui Li ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Covalent Organic Framework ◽  
Tumor Gene Therapy ◽  
Tumor Gene ◽  
Organic Framework

scholarly journals Advancement and prospects of tumor gene therapy

2011 ◽  
Vol 30 (3) ◽  
pp. 182-188 ◽  
Author(s):  
Chao Zhang ◽  
Qing-Tao Wang ◽  
He Liu ◽  
Zhen-Zhu Zhang ◽  
Wen-Lin Huang
Keyword(s):  
Gene Therapy ◽  
Tumor Gene Therapy ◽  
Tumor Gene

The research of nanoparticles as gene vector for tumor gene therapy

2014 ◽  
Vol 89 (3) ◽  
pp. 352-357 ◽  
Author(s):  
Nian-feng Sun ◽  
Zhan-ao Liu ◽  
Wen-bai Huang ◽  
Ai-ling Tian ◽  
San-yuan Hu
Keyword(s):  
Gene Therapy ◽  
Gene Vector ◽  
Tumor Gene Therapy ◽  
Tumor Gene

scholarly journals Biodegradable PEI modified complex micelles as gene carriers with tunable gene transfection efficiency for ECs

2016 ◽  
Vol 4 (5) ◽  
pp. 997-1008 ◽  
Author(s):  
Juan Lv ◽  
Jing Yang ◽  
Xuefang Hao ◽  
Xiangkui Ren ◽  
Yakai Feng ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Vascular Grafts ◽  
Gene Carriers ◽  
Coronary Diseases ◽  
Potential Strategy ◽  
Complex Micelles

In recent years, gene therapy has evoked an increasing interest in clinical treatments of coronary diseases because it is a potential strategy to realize rapid endothelialization of artificial vascular grafts.

scholarly journals Wild-type p53 gene transfer is not detrimental to normal cells in vivo: implications for tumor gene therapy

Oncogene ◽  
2004 ◽  
Vol 23 (2) ◽  
pp. 418-425 ◽  
Author(s):  
Gianluca Bossi ◽  
Giuseppina Mazzaro ◽  
Alessandro Porrello ◽  
Marco Crescenzi ◽  
Silvia Soddu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gene Transfer ◽  
P53 Gene ◽  
Wild Type ◽  
Normal Cells ◽  
Tumor Gene Therapy ◽  
Wild Type P53 ◽  
Tumor Gene

scholarly journals Analysis of the Immunologic Response Generated by Ad.IFN-β During Successful Intraperitoneal Tumor Gene Therapy

2002 ◽  
Vol 6 (2) ◽  
pp. 210-218 ◽  
Author(s):  
Makoto Odaka ◽  
Rainer Wiewrodt ◽  
Peter A DeLong ◽  
Tomoyuki Tanaka ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Immunologic Response ◽  
Tumor Gene Therapy ◽  
Tumor Gene
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