pH and Glutathione Synergistically Triggered Release and Self-Assembly of Au Nanospheres for Tumor Theranostics

2020 ◽  
Vol 12 (7) ◽  
pp. 8050-8061 ◽  
Author(s):  
Lu An ◽  
Mei Cao ◽  
Xue Zhang ◽  
Jiaomin Lin ◽  
Qiwei Tian ◽  
...  
Keyword(s):  
Self Assembly ◽  
Triggered Release ◽  
Tumor Theranostics

Oxidation and ATP dual-responsive block copolymer containing tertiary sulfoniums: self-assembly, protein complexation and triggered release

2021 ◽  
Author(s):  
Yanfen Jiang ◽  
Shuqi Dong ◽  
Guoyang Qin ◽  
Li Liu ◽  
Hanying Zhao
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Phenylboronic Acid ◽  
Cationic Polymer ◽  
Release Profile ◽  
Triggered Release ◽  
Dual Responsive ◽  
Protein Complexation

Alkylation of thioether-containing block copolymer simultaneously incorporated sulfoniums and phenylboronic acid moieties. The co-assembly of this cationic polymer and protein generated micelles with an H2O2-and ATP-responsive release profile.

Fluorescent amphiphilic copolymer-based tumor theranostics for facile DOX-loading and tumor microenvironment-triggered release

2016 ◽  
Vol 105 ◽  
pp. 333-340 ◽  
Author(s):  
Xu Jia ◽  
Kun Tian ◽  
Xubo Zhao ◽  
Tingting Zhou ◽  
Mingliang Pei ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Amphiphilic Copolymer ◽  
Triggered Release ◽  
Tumor Theranostics

scholarly journals Supramolecular Structures and Self-Association Processes in Polymer Systems

2016 ◽  
pp. S165-S178 ◽  
Author(s):  
M. HRUBÝ ◽  
S. K. FILIPPOV ◽  
P. ŠTĚPÁNEK
Keyword(s):  
Self Assembly ◽  
Targeted Delivery ◽  
Aqueous Media ◽  
Polymer System ◽  
Chemical Properties ◽  
Building Blocks ◽  
Self Organization ◽  
Triggered Release ◽  
Polymer Systems ◽  
Self Association

Self-organization in a polymer system appears when a balance is achieved between long-range repulsive and short-range attractive forces between the chemically different building blocks. Block copolymers forming supramolecular assemblies in aqueous media represent materials which are extremely useful for the construction of drug delivery systems especially for cancer applications. Such formulations suppress unwanted physico-chemical properties of the encapsulated drugs, modify biodistribution of the drugs towards targeted delivery into tissue of interest and allow triggered release of the active cargo. In this review, we focus on general principles of polymer self-organization in solution, phase separation in polymer systems (driven by external stimuli, especially by changes in temperature, pH, solvent change and light) and on effects of copolymer architecture on the self-assembly process.

scholarly journals pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

2015 ◽  
Vol 6 ◽  
pp. 2504-2512 ◽  
Author(s):  
Manuel Häuser ◽  
Klaus Langer ◽  
Monika Schönhoff
Keyword(s):  
Self Assembly ◽  
Glycolic Acid ◽  
Ph Value ◽  
Particle System ◽  
Plga Nanoparticles ◽  
Ph Sensitive ◽  
Layer By Layer ◽  
Triggered Release ◽  
Layer System ◽  
H Nmr

Nanoparticles (NP) of poly(lactic-co-glycolic acid) (PLGA) represent a promising biodegradable drug delivery system. We suggest here a two-step release system of PLGA nanoparticles with a pH-tunable polymeric shell, providing an initial pH-triggered step, releasing a membrane-toxic cationic compound. PLGA nanoparticles are coated by polyelectrolytes using the layer-by-layer self-assembly technique, employing poly(acrylic acid) (PAA) as a pH-sensitive component and poly(diallyldimethylammonium chloride) (PDADMAC) as the releasable polycation. The pH during multilayer deposition plays a major role and influences the titration curve of the layer system. The pH-tunability of PAA is intensively investigated with regard to the pH region, in which the particle system becomes uncharged. The isoelectric point can be shifted by employing suitable deposition pH values. The release is investigated by quantitative 1H NMR, yielding a pH-dependent release curve. A release of PDADMAC is initiated by a decrease of the pH value. The released amount of polymer, as quantified by 1H NMR analysis, clearly depends on the pH value and thus on the state of deprotonation of the pH-sensitive PAA layer. Subsequent incubation of the nanoparticles with high concentrations of sodium chloride shows no further release and thus demonstrates the pH-driven release to be quantitative.

scholarly journals Loading of Silica Nanoparticles in Block Copolymer Vesicles during Polymerization-Induced Self-Assembly: Encapsulation Efficiency and Thermally Triggered Release

2015 ◽  
Vol 137 (51) ◽  
pp. 16098-16108 ◽  
Author(s):  
Charlotte J. Mable ◽  
Rebecca R. Gibson ◽  
Sylvain Prevost ◽  
Beulah E. McKenzie ◽  
Oleksandr O. Mykhaylyk ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Silica Nanoparticles ◽  
Self Assembly ◽  
Encapsulation Efficiency ◽  
Triggered Release ◽  
Thermally Triggered

scholarly journals Controlled Release of Ibuprofen from Polymeric Nanoparticles

2019 ◽  
Author(s):  
Sara Shehata ◽  
Christopher Serpell ◽  
Stefano Biagini
Keyword(s):  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Controlled Delivery ◽  
Therapeutic Drug ◽  
Triggered Release ◽  
Polymeric Systems ◽  
Polymeric Nanoparticle ◽  
Alkaline Conditions ◽  
Nanoparticle System ◽  
Poly Ethylene

Smart polymeric systems are required that are able to release a therapeutic drug with controlled delivery. Herein we investigated the pH triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of ibuprofen and poly(ethylene)glycol monomers followed by self-assembly produced a nanoparticle system that was shown to be stable at neutral pH but releases ibuprofen in alkaline conditions

scholarly journals Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2381
Author(s):  
Gina M. DiSalvo ◽  
Abby R. Robinson ◽  
Mohamed S. Aly ◽  
Eric R. Hoglund ◽  
Sean M. O’Malley ◽  
...  
Keyword(s):  
Self Assembly ◽  
Diblock Copolymers ◽  
Single Pulse ◽  
Plasmonic Nanoparticles ◽  
Pulse Irradiation ◽  
Triggered Release ◽  
Hydrophobic Membrane ◽  
Polymeric Vesicles ◽  
Vesicle Rupture ◽  
Amphiphilic Diblock Copolymers

The self-assembly of amphiphilic diblock copolymers into polymeric vesicles, commonly known as polymersomes, results in a versatile system for a variety of applications including drug delivery and microreactors. In this study, we show that the incorporation of hydrophobic plasmonic nanoparticles within the polymersome membrane facilitates light-stimulated release of vesicle encapsulants. This work seeks to achieve tunable, triggered release with non-invasive, spatiotemporal control using single-pulse irradiation. Gold nanoparticles (AuNPs) are incorporated as photosensitizers into the hydrophobic membrane of micron-scale polymersomes and the cargo release profile is controlled by varying the pulse energy and nanoparticle concentration. We have demonstrated the ability to achieve immediate vesicle rupture as well as vesicle poration resulting in temporal cargo diffusion. Additionally, changing the pulse duration, from femtosecond to nanosecond, provides mechanistic insight into the photothermal and photomechanical contributors that govern membrane disruption in this polymer–nanoparticle hybrid system.

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