Demolish and Rebuild: Controlling Lipid Self-Assembly toward Triggered Release and Artificial Cells

2021 ◽  
Author(s):  
Megan L. Qualls ◽  
Ruhani Sagar ◽  
Jinchao Lou ◽  
Michael D. Best
Keyword(s):  
Self Assembly ◽  
Triggered Release ◽  
Artificial Cells

Oxidation and ATP dual-responsive block copolymer containing tertiary sulfoniums: self-assembly, protein complexation and triggered release

2021 ◽  
Author(s):  
Yanfen Jiang ◽  
Shuqi Dong ◽  
Guoyang Qin ◽  
Li Liu ◽  
Hanying Zhao
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Phenylboronic Acid ◽  
Cationic Polymer ◽  
Release Profile ◽  
Triggered Release ◽  
Dual Responsive ◽  
Protein Complexation

Alkylation of thioether-containing block copolymer simultaneously incorporated sulfoniums and phenylboronic acid moieties. The co-assembly of this cationic polymer and protein generated micelles with an H2O2-and ATP-responsive release profile.

Light-induced ATP driven self-assembly of actin and heavy-meromyosin in proteo-tubularsomes as a step toward artificial cells

2018 ◽  
Vol 54 (42) ◽  
pp. 5346-5349 ◽  
Author(s):  
Satarupa Dhir ◽  
Sumalee Salahub ◽  
Anu Stella Mathews ◽  
Surjith Kumar Kumaran ◽  
Carlo D. Montemagno ◽  
...  
Keyword(s):  
Self Assembly ◽  
Heavy Meromyosin ◽  
Artificial Cells

In this work we studied the light induced self-assembly of F-actin and heavy meromyosin (HMM) in tubular vesicles or “tubularsomes” during initiation by ATP.

scholarly journals Supramolecular Structures and Self-Association Processes in Polymer Systems

2016 ◽  
pp. S165-S178 ◽  
Author(s):  
M. HRUBÝ ◽  
S. K. FILIPPOV ◽  
P. ŠTĚPÁNEK
Keyword(s):  
Self Assembly ◽  
Targeted Delivery ◽  
Aqueous Media ◽  
Polymer System ◽  
Chemical Properties ◽  
Building Blocks ◽  
Self Organization ◽  
Triggered Release ◽  
Polymer Systems ◽  
Self Association

Self-organization in a polymer system appears when a balance is achieved between long-range repulsive and short-range attractive forces between the chemically different building blocks. Block copolymers forming supramolecular assemblies in aqueous media represent materials which are extremely useful for the construction of drug delivery systems especially for cancer applications. Such formulations suppress unwanted physico-chemical properties of the encapsulated drugs, modify biodistribution of the drugs towards targeted delivery into tissue of interest and allow triggered release of the active cargo. In this review, we focus on general principles of polymer self-organization in solution, phase separation in polymer systems (driven by external stimuli, especially by changes in temperature, pH, solvent change and light) and on effects of copolymer architecture on the self-assembly process.

scholarly journals pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

2015 ◽  
Vol 6 ◽  
pp. 2504-2512 ◽  
Author(s):  
Manuel Häuser ◽  
Klaus Langer ◽  
Monika Schönhoff
Keyword(s):  
Self Assembly ◽  
Glycolic Acid ◽  
Ph Value ◽  
Particle System ◽  
Plga Nanoparticles ◽  
Ph Sensitive ◽  
Layer By Layer ◽  
Triggered Release ◽  
Layer System ◽  
H Nmr

Nanoparticles (NP) of poly(lactic-co-glycolic acid) (PLGA) represent a promising biodegradable drug delivery system. We suggest here a two-step release system of PLGA nanoparticles with a pH-tunable polymeric shell, providing an initial pH-triggered step, releasing a membrane-toxic cationic compound. PLGA nanoparticles are coated by polyelectrolytes using the layer-by-layer self-assembly technique, employing poly(acrylic acid) (PAA) as a pH-sensitive component and poly(diallyldimethylammonium chloride) (PDADMAC) as the releasable polycation. The pH during multilayer deposition plays a major role and influences the titration curve of the layer system. The pH-tunability of PAA is intensively investigated with regard to the pH region, in which the particle system becomes uncharged. The isoelectric point can be shifted by employing suitable deposition pH values. The release is investigated by quantitative 1H NMR, yielding a pH-dependent release curve. A release of PDADMAC is initiated by a decrease of the pH value. The released amount of polymer, as quantified by 1H NMR analysis, clearly depends on the pH value and thus on the state of deprotonation of the pH-sensitive PAA layer. Subsequent incubation of the nanoparticles with high concentrations of sodium chloride shows no further release and thus demonstrates the pH-driven release to be quantitative.

scholarly journals Loading of Silica Nanoparticles in Block Copolymer Vesicles during Polymerization-Induced Self-Assembly: Encapsulation Efficiency and Thermally Triggered Release

2015 ◽  
Vol 137 (51) ◽  
pp. 16098-16108 ◽  
Author(s):  
Charlotte J. Mable ◽  
Rebecca R. Gibson ◽  
Sylvain Prevost ◽  
Beulah E. McKenzie ◽  
Oleksandr O. Mykhaylyk ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Silica Nanoparticles ◽  
Self Assembly ◽  
Encapsulation Efficiency ◽  
Triggered Release ◽  
Thermally Triggered

pH and Glutathione Synergistically Triggered Release and Self-Assembly of Au Nanospheres for Tumor Theranostics

2020 ◽  
Vol 12 (7) ◽  
pp. 8050-8061 ◽  
Author(s):  
Lu An ◽  
Mei Cao ◽  
Xue Zhang ◽  
Jiaomin Lin ◽  
Qiwei Tian ◽  
...  
Keyword(s):  
Self Assembly ◽  
Triggered Release ◽  
Tumor Theranostics

scholarly journals Controlled Release of Ibuprofen from Polymeric Nanoparticles

2019 ◽  
Author(s):  
Sara Shehata ◽  
Christopher Serpell ◽  
Stefano Biagini
Keyword(s):  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Controlled Delivery ◽  
Therapeutic Drug ◽  
Triggered Release ◽  
Polymeric Systems ◽  
Polymeric Nanoparticle ◽  
Alkaline Conditions ◽  
Nanoparticle System ◽  
Poly Ethylene

Smart polymeric systems are required that are able to release a therapeutic drug with controlled delivery. Herein we investigated the pH triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of ibuprofen and poly(ethylene)glycol monomers followed by self-assembly produced a nanoparticle system that was shown to be stable at neutral pH but releases ibuprofen in alkaline conditions

scholarly journals Enzyme-free synthesis of natural phospholipids in water

2019 ◽  
Author(s):  
Luping Liu ◽  
Yike Zou ◽  
Ahanjit Bhattacharya ◽  
Dongyang Zhang ◽  
Susan Q. Lang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Soda Lakes ◽  
Building Blocks ◽  
Alkaline Solutions ◽  
Artificial Cells ◽  
Proton Gradients ◽  
Aqueous Synthesis ◽  
Acidic Solutions ◽  
Membrane Bound ◽  
Living Organisms

AbstractAll living organisms synthesize phospholipids as the primary constituent of their cell membranes. While phospholipids can spontaneously self-assemble in water to form membrane-bound vesicles, their aqueous synthesis requires pre-existing membrane-embedded enzymes. This limitation has led to models in which the first cells used simpler types of membrane building blocks and has hampered integration of phospholipid synthesis into artificial cells. Here we demonstrate that a combination of ion pairing and self-assembly of reactants allows high-yielding synthesis of cellular phospholipids in water. Acylation of 2-lysophospholipids using cationic thioesters occurs in mildly alkaline solutions resulting in the formation of cell-like membranes. A variety of membrane-forming natural phospholipids can be synthesized. Membrane formation takes place in water from natural alkaline sources, such as soda lakes and hydrothermal oceanic vents. When formed vesicles are transferred to more acidic solutions, electrochemical proton gradients are spontaneously established and maintained.

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