Photocleavable and tunable thermoresponsive amphiphilic random copolymer: Self-assembly into micelles, dye encapsulation, and triggered release

2017 ◽  
Vol 55 (10) ◽  
pp. 1714-1729 ◽  
Author(s):  
Somdeb Jana ◽  
Avijit Bose ◽  
Anupam Saha ◽  
Tarun K. Mandal
Keyword(s):  
Self Assembly ◽  
Random Copolymer ◽  
Triggered Release

scholarly journals Quadruple Hydrogen Bond-Containing A-AB-A Triblock Copolymers: Probing the Influence of Hydrogen Bonding in the Central Block

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4705
Author(s):  
Boer Liu ◽  
Xi Chen ◽  
Glenn A. Spiering ◽  
Robert B. Moore ◽  
Timothy E. Long
Keyword(s):  
Hydrogen Bonding ◽  
Self Assembly ◽  
Microphase Separation ◽  
Triblock Copolymers ◽  
Random Copolymer ◽  
Thermomechanical Properties ◽  
Structure Property ◽  
Scanning Calorimetry ◽  
Central Block ◽  
Quadruple Hydrogen Bonding

This work reveals the influence of pendant hydrogen bonding strength and distribution on self-assembly and the resulting thermomechanical properties of A-AB-A triblock copolymers. Reversible addition-fragmentation chain transfer polymerization afforded a library of A-AB-A acrylic triblock copolymers, wherein the A unit contained cytosine acrylate (CyA) or post-functionalized ureido cytosine acrylate (UCyA) and the B unit consisted of n-butyl acrylate (nBA). Differential scanning calorimetry revealed two glass transition temperatures, suggesting microphase-separation in the A-AB-A triblock copolymers. Thermomechanical and morphological analysis revealed the effects of hydrogen bonding distribution and strength on the self-assembly and microphase-separated morphology. Dynamic mechanical analysis showed multiple tan delta (δ) transitions that correlated to chain relaxation and hydrogen bonding dissociation, further confirming the microphase-separated structure. In addition, UCyA triblock copolymers possessed an extended modulus plateau versus temperature compared to the CyA analogs due to the stronger association of quadruple hydrogen bonding. CyA triblock copolymers exhibited a cylindrical microphase-separated morphology according to small-angle X-ray scattering. In contrast, UCyA triblock copolymers lacked long-range ordering due to hydrogen bonding induced phase mixing. The incorporation of UCyA into the soft central block resulted in improved tensile strength, extensibility, and toughness compared to the AB random copolymer and A-B-A triblock copolymer comparisons. This study provides insight into the structure-property relationships of A-AB-A supramolecular triblock copolymers that result from tunable association strengths.

Oxidation and ATP dual-responsive block copolymer containing tertiary sulfoniums: self-assembly, protein complexation and triggered release

2021 ◽  
Author(s):  
Yanfen Jiang ◽  
Shuqi Dong ◽  
Guoyang Qin ◽  
Li Liu ◽  
Hanying Zhao
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Phenylboronic Acid ◽  
Cationic Polymer ◽  
Release Profile ◽  
Triggered Release ◽  
Dual Responsive ◽  
Protein Complexation

Alkylation of thioether-containing block copolymer simultaneously incorporated sulfoniums and phenylboronic acid moieties. The co-assembly of this cationic polymer and protein generated micelles with an H2O2-and ATP-responsive release profile.

Multi-responsive hollow nanospheres self-assembly by amphiphilic random copolymer and azobenzene

Polymer ◽  
2019 ◽  
Vol 175 ◽  
pp. 235-242 ◽  
Author(s):  
Yihan Wang ◽  
Lizhi Hu ◽  
Qiang Yin ◽  
Kai Du ◽  
Taoran Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Random Copolymer ◽  
Hollow Nanospheres

Synthesis of bottlebrush block copolymers from bottlebrush polystyrene and bottlebrush random copolymer of ω ‐end‐norbornyl polymethacrylates and their self‐assembly

2020 ◽  
Vol 58 (16) ◽  
pp. 2159-2167 ◽  
Author(s):  
Ho‐Bin Seo ◽  
Myung‐Jin Kim ◽  
Yong‐Guen Yu ◽  
Chang‐Geun Chae ◽  
Jae‐Suk Lee
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Random Copolymer

scholarly journals Complex Temperature and Concentration Dependent Self-Assembly of Poly(2-oxazoline) Block Copolymers

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1495 ◽  
Author(s):  
Loan Trinh Che ◽  
Marianne Hiorth ◽  
Richard Hoogenboom ◽  
Anna-Lena Kjøniksen
Keyword(s):  
High Temperatures ◽  
Self Assembly ◽  
Low Temperatures ◽  
Polymer Concentration ◽  
Random Copolymer ◽  
Polymer Chains ◽  
Relaxation Modes ◽  
Self Association ◽  
Copolymer Structure ◽  
Complex Temperature

The effect of polymer concentration on the temperature-induced self-association of a block copolymer comprising a poly(2-ethyl-2-oxazoline) block and a random copolymer block consisting of 2-ethyl-2-oxazoline and 2-n-propyl-2-oxazoline (PEtO80-block-P(EtOxx-stat-PropO40-x) with x = 0, 4, or 8 were investigated by dynamic light scattering (DLS) and transmittance measurements (turbidimetry). The polymers reveal a complex aggregation behavior with up to three relaxation modes in the DLS data and with a transmittance that first goes through a minimum before it declines at high temperatures. At low temperatures, unassociated polymer chains were found to co-exist with larger aggregates. As the temperature is increased, enhanced association and contraction of the aggregates results in a drop of the transmittance values. The aggregates fragment into smaller micellar-like clusters when the temperature is raised further, causing the samples to become optically clear again. At high temperatures, the polymers aggregate into large compact clusters, and the samples become turbid. Interestingly, very large aggregates were observed at low temperatures when the polymer concentrations were low. The formation of these aggregates was also promoted by a more hydrophilic copolymer structure. The formation of large aggregates with an open structure at conditions where the solvent conditions are improved is probably caused by depletion flocculation of the smaller aggregates.

Self-Assembly Behavior of A-B Diblock and C-D Random Copolymer Mixtures in the Solution State through Mediated Hydrogen Bonding

Langmuir ◽  
2008 ◽  
Vol 24 (15) ◽  
pp. 7727-7734 ◽  
Author(s):  
Chih-Hao Hsu ◽  
Shiao-Wei Kuo ◽  
Jem-Kun Chen ◽  
Fu-Hsiang Ko ◽  
Chun-Syong Liao ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Self Assembly ◽  
Random Copolymer ◽  
Solution State ◽  
Assembly Behavior

scholarly journals Supramolecular Structures and Self-Association Processes in Polymer Systems

2016 ◽  
pp. S165-S178 ◽  
Author(s):  
M. HRUBÝ ◽  
S. K. FILIPPOV ◽  
P. ŠTĚPÁNEK
Keyword(s):  
Self Assembly ◽  
Targeted Delivery ◽  
Aqueous Media ◽  
Polymer System ◽  
Chemical Properties ◽  
Building Blocks ◽  
Self Organization ◽  
Triggered Release ◽  
Polymer Systems ◽  
Self Association

Self-organization in a polymer system appears when a balance is achieved between long-range repulsive and short-range attractive forces between the chemically different building blocks. Block copolymers forming supramolecular assemblies in aqueous media represent materials which are extremely useful for the construction of drug delivery systems especially for cancer applications. Such formulations suppress unwanted physico-chemical properties of the encapsulated drugs, modify biodistribution of the drugs towards targeted delivery into tissue of interest and allow triggered release of the active cargo. In this review, we focus on general principles of polymer self-organization in solution, phase separation in polymer systems (driven by external stimuli, especially by changes in temperature, pH, solvent change and light) and on effects of copolymer architecture on the self-assembly process.

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