Robust Biopolymeric Supramolecular “Host−Guest Macromer” Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration

2016 ◽  
Vol 49 (3) ◽  
pp. 866-875 ◽  
Author(s):  
Kongchang Wei ◽  
Meiling Zhu ◽  
Yuxin Sun ◽  
Jianbin Xu ◽  
Qian Feng ◽  
...  
Keyword(s):  
Cartilage Regeneration

Scaffolds for Drug Delivery in Tissue Engineering

2008 ◽  
Vol 1 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Vikas V. Gaikwad ◽  
Abasaheb B. Patil ◽  
Madhuri V. Gaikwad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Heart Diseases ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
The Body ◽  
Patient Specific ◽  
In Situ Gel ◽  
Heart Muscle Cells

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth.  Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

Cell-free macro-porous fibrin scaffolds for in situ inductive regeneration of full-thickness cartilage defects

2016 ◽  
Vol 4 (25) ◽  
pp. 4410-4419 ◽  
Author(s):  
Yuankun Dai ◽  
Gang Liu ◽  
Lie Ma ◽  
Dongan Wang ◽  
Changyou Gao
Keyword(s):  
Growth Factors ◽  
Cartilage Regeneration ◽  
Cartilage Defects ◽  
Full Thickness ◽  
Fibrin Scaffold

Macro-porous fibrin scaffold was fabricated and used to induce cartilage regenerationin situwithout pre-loaded cells or growth factors.

Injectable amine functionalized graphene and chondroitin sulfate hydrogel with potential for cartilage regeneration

2019 ◽  
Vol 7 (15) ◽  
pp. 2442-2453 ◽  
Author(s):  
Caoxin Tang ◽  
Brian D. Holt ◽  
Zoe M. Wright ◽  
Anne M. Arnold ◽  
Alexandra C. Moy ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Cartilage Regeneration ◽  
Functionalized Graphene ◽  
Injectable Hydrogel ◽  
Amine Functionalized ◽  
Cartilage Therapy

Chemically functionalized graphene covalently reactsin situwith chondroitin sulfate to form an enhanced, injectable hydrogel for potential cartilage therapy.

In situ forming hydrogels of hyaluronic acid and inulin derivatives for cartilage regeneration

2015 ◽  
Vol 122 ◽  
pp. 408-416 ◽  
Author(s):  
Fabio S. Palumbo ◽  
Calogero Fiorica ◽  
Mauro Di Stefano ◽  
Giovanna Pitarresi ◽  
Alessandro Gulino ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cartilage Regeneration ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

scholarly journals Application of robotic-assisted in situ 3D printing in cartilage regeneration with HAMA hydrogel: An in vivo study

2020 ◽  
Vol 23 ◽  
pp. 123-132 ◽  
Author(s):  
Kaiwei Ma ◽  
Tianzheng Zhao ◽  
Longfei Yang ◽  
Peng Wang ◽  
Jing Jin ◽  
...  
Keyword(s):  
3D Printing ◽  
Cartilage Regeneration ◽  
In Vivo Study ◽  
Robotic Assisted

Cell-Homing Strategies for in Situ Articular Cartilage Regeneration

2020 ◽  
Author(s):  
Zhen Yang ◽  
Hao Li ◽  
Weimin Guo ◽  
Zhiguo Yuan ◽  
Liwei Fu ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Cell Homing ◽  
Articular Cartilage Regeneration

Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration

Nanoscale ◽  
2017 ◽  
Vol 9 (13) ◽  
pp. 4430-4438 ◽  
Author(s):  
Xiaolin Liu ◽  
Yunlong Yang ◽  
Yan Li ◽  
Xin Niu ◽  
Bizeng Zhao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
In Situ Hydrogel ◽  
Articular Cartilage Regeneration

Current Intelligent Injectable Hydrogels for In Situ Articular Cartilage Regeneration

2019 ◽  
Vol 60 (2) ◽  
pp. 203-225 ◽  
Author(s):  
Youguo Liao ◽  
Qiulin He ◽  
Feifei Zhou ◽  
Jingwei Zhang ◽  
Renjie Liang ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Injectable Hydrogels ◽  
Articular Cartilage Regeneration

scholarly journals In situ handheld three‐dimensional bioprinting for cartilage regeneration

2017 ◽  
Vol 12 (3) ◽  
pp. 611-621 ◽  
Author(s):  
Claudia Di Bella ◽  
Serena Duchi ◽  
Cathal D. O'Connell ◽  
Romane Blanchard ◽  
Cheryl Augustine ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Cartilage Regeneration
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