In Situ Articular Cartilage Regeneration through Endogenous Reparative Cell Homing Using a Functional Bone Marrow-Specific Scaffolding System

2018 ◽  
Vol 10 (45) ◽  
pp. 38715-38728 ◽  
Author(s):  
Xun Sun ◽  
Heyong Yin ◽  
Yu Wang ◽  
Jiaju Lu ◽  
Xuezhen Shen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Cell Homing ◽  
Articular Cartilage Regeneration

Cell-Homing Strategies for in Situ Articular Cartilage Regeneration

2020 ◽  
Author(s):  
Zhen Yang ◽  
Hao Li ◽  
Weimin Guo ◽  
Zhiguo Yuan ◽  
Liwei Fu ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Cell Homing ◽  
Articular Cartilage Regeneration

In Situ Recruitment of Human Bone Marrow-Derived Mesenchymal Stem Cells Using Chemokines for Articular Cartilage Regeneration

2015 ◽  
Vol 24 (6) ◽  
pp. 1067-1083 ◽  
Author(s):  
Min Sung Park ◽  
Yun Hee Kim ◽  
Youngmee Jung ◽  
Soo Hyun Kim ◽  
Jong Chul Park ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Articular Cartilage Regeneration

Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration

Nanoscale ◽  
2017 ◽  
Vol 9 (13) ◽  
pp. 4430-4438 ◽  
Author(s):  
Xiaolin Liu ◽  
Yunlong Yang ◽  
Yan Li ◽  
Xin Niu ◽  
Bizeng Zhao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
In Situ Hydrogel ◽  
Articular Cartilage Regeneration

Current Intelligent Injectable Hydrogels for In Situ Articular Cartilage Regeneration

2019 ◽  
Vol 60 (2) ◽  
pp. 203-225 ◽  
Author(s):  
Youguo Liao ◽  
Qiulin He ◽  
Feifei Zhou ◽  
Jingwei Zhang ◽  
Renjie Liang ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Injectable Hydrogels ◽  
Articular Cartilage Regeneration

scholarly journals Hierarchical macro-microporous WPU-ECM scaffolds combined with Microfracture Promote in Situ Articular Cartilage Regeneration in Rabbits

2021 ◽  
Vol 6 (7) ◽  
pp. 1932-1944
Author(s):  
Mingxue Chen ◽  
YangYang Li ◽  
Shuyun Liu ◽  
Zhaoxuan Feng ◽  
Hao Wang ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

Articular cartilage regeneration in rats using human bone marrow stromal cells

2021 ◽  
Vol 29 ◽  
pp. S68-S69
Author(s):  
S.S. Paravastu ◽  
B.W. Mui ◽  
S.J. Gadomski ◽  
R. Merling ◽  
S. Kuznetsov ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Articular Cartilage ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Cartilage Regeneration ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Articular Cartilage Regeneration

scholarly journals Biofunctionalized Structure and Ingredient Mimicking Scaffolds Achieving Recruitment and Chondrogenesis for Staged Cartilage Regeneration

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhen Yang ◽  
Hao Li ◽  
Yue Tian ◽  
Liwei Fu ◽  
Cangjian Gao ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Growth Factor ◽  
Chondrogenic Differentiation ◽  
Cartilage Regeneration ◽  
Recruitment Strategy ◽  
Prolonged Release ◽  
Cell Recruitment ◽  
Articular Cartilage Regeneration

It remains scientifically challenging to regenerate injured cartilage in orthopedics. Recently, an endogenous cell recruitment strategy based on a combination of acellular scaffolds and chemoattractants to specifically and effectively recruit host cells and promote chondrogenic differentiation has brought new hope for in situ articular cartilage regeneration. In this study, a transforming growth factor-β3 (TGF-β3)-loaded biomimetic natural scaffold based on demineralized cancellous bone (DCB) and acellular cartilage extracellular matrix (ECM) was developed and found to improve chondral repair by enhancing cell migration and chondrogenesis. The DCB/ECM scaffold has porous microstructures (pore size: 67.76 ± 8.95 μm; porosity: 71.04 ± 1.62%), allowing the prolonged release of TGF-β3 (up to 50% after 42 days in vitro) and infrapatellar fat pad adipose-derived stem cells (IPFSCs) that maintain high cell viability (>96%) and favorable cell distribution and phenotype after seeding onto the DCB/ECM scaffold. The DCB/ECM scaffold itself can also provide a sustained release system to effectively promote IPFSC migration (nearly twofold in vitro). Moreover, TGF-β3 loaded on scaffolds showed enhanced chondrogenic differentiation (such as collagen II, ACAN, and SOX9) of IPFSCs after 3 weeks of culture. After implanting the composite scaffold into the knee joints of rabbits, enhanced chondrogenic differentiation was discovered at 1, 2, and 4 weeks post-surgery, and improved repair of cartilage defects in terms of biochemical, biomechanical, radiological, and histological results was identified at 3 and 6 months post-implantation. To conclude, our study demonstrates that the growth factor (GF)-loaded scaffold can facilitate cell homing, migration, and chondrogenic differentiation and promote the reconstructive effects of in vivo cartilage formation, revealing that this staged regeneration strategy combined with endogenous cell recruitment and pro-chondrogenesis is promising for in situ articular cartilage regeneration.

scholarly journals Second-Look Arthroscopic Evaluation and Clinical Outcome after the Supramalleolar Osteotomy for the Medial Compartment Ankle Osteoarthritis

2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0000
Author(s):  
Hong-Geun Jung ◽  
Joon-Sang Eom ◽  
Dong-Oh Lee ◽  
Mao Yuan Sun ◽  
Hwa Jun Kang
Keyword(s):  
Bone Marrow ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Medial Compartment ◽  
Ankle Osteoarthritis ◽  
Bone Marrow Stimulation ◽  
Second Look ◽  
Supramalleolar Osteotomy ◽  
The Mean ◽  
Articular Cartilage Regeneration

Category: Ankle, Ankle Arthritis, Arthroscopy, Hindfoot Introduction/Purpose: This study aimed to evaluate the clinical and radiological outcomes of asymmetric ankle osteoarthritis after supramalleolar osteotomy (SMO) without BMSP(bone marrow stimulation procedure) and confirm cartilage recovery by second look arthroscopy. The hypothesis was that SMO without BMSP for medial compartment ankle osteoarthritis would show tibio-talar articular cartilage regeneration in the medial compartment, as well as satisfactory clinical and radiological outcomes. Methods: We retrospectively reviewed 20 ankles of 18 consecutive patients who were followed up for over 1 year after SMO from August 2007 to February 2013. Visual analog scale (VAS) pain scores and the AOFAS ankle-hindfoot scores were used for the functional evaluations. The tibial anterior surface angles and the tibial lateral surface angles were measured on radiographs, and the ankle osteoarthritis was classified by the Takakura stage. Among the 20cases, 19 caseshad ankle arthroscopy performedprior to SMO, and second-look ankle arthroscopywas performed in 14 cases at postoperative 1 year. Tibio-talarcartilage regeneration was evaluatedaccording to the modified Outerbridge classification for the 12 cases that had undergone SMO without a bone marrow–stimulating procedure (BMSP). Results: The mean VAS and AOFAS scores significantly improved from 6.7 preoperatively to 1.2 postoperatively and from 60.9 preoperatively to 87.9 postoperatively, respectively (P<0.05). The mean TAS and TLS angles significantly improved from 83.5? and 76.5preoperatively to 94.4? and 80.3? postoperatively respectively (P<0.05). All preoperative TakakurastageIIIa cases and 1 case of preoperative stage IIIb improved to postoperative stage II. At 2nd look arthroscopy, articular cartilage regeneration of the medial compartment of the tibio-talar joint was observed in 10 of 12 cases (83%), whereas cartilage deterioration was not observed in any case.Cartilage grading, however, did not show correlations with clinical outcomes. Conclusion: SMO without BMSP for medial compartment ankle osteoarthritis demonstrated marked tibio-talar articular cartilage regeneration in the medial compartment (83%) by second look arthroscopy, as well as satisfactory clinical and radiological outcomes.

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