Decarboxylative Mannich Reactions with Substituted Malonic Acid Half-Oxyesters

2021 ◽  
Vol 86 (8) ◽  
pp. 5452-5462
Author(s):  
Tania Xavier ◽  
Sylvie Condon ◽  
Christophe Pichon ◽  
Erwan Le Gall ◽  
Marc Presset
Keyword(s):  
Malonic Acid ◽  
Mannich Reactions

Advances on Asymmetric Organocatalyzed Mannich Reactions in Aqueous and Non-aqueous Media

2016 ◽  
Vol 3 (2) ◽  
pp. 133-160 ◽  
Author(s):  
Ayndrila Ghosh ◽  
Sudipto Bhowmick ◽  
Anirban Mondal ◽  
Harekrishna Garai ◽  
Kartick C. Bhowmick
Keyword(s):  
Aqueous Media ◽  
Mannich Reactions

3-(s-Hydrindacen-4-yl)propylamines and 4-(s-hydrindacen-4-yl)butylamines; Synthesis and pharmacological screening

1981 ◽  
Vol 46 (8) ◽  
pp. 1800-1807 ◽  
Author(s):  
Zdeněk Vejdělek ◽  
Marie Bartošová ◽  
Miroslav Protiva
Keyword(s):  
Malonic Acid ◽  
Local Anaesthetics ◽  
Lithium Aluminium Hydride ◽  
Spasmolytic Activity ◽  
Lithium Aluminium ◽  
Malonic Acid Derivatives ◽  
Pharmacological Screening ◽  
Hydroxyethyl Piperazine

4-Chloromethyl-s-hydrindacene (VIIa) was transformed via the malonic acid derivatives VIIIa and IXa to the acid Xb which afforded in four steps the homological acid Xc. Reactions of chlorides of both acids (XIbc ) with dimethylamine, 1-methylpiperazine and 1-(2-hydroxyethyl)piperazine led to the amides XIIbc-XIVbc which were reduced with lithium aluminium hydride to the title compounds IVcd-VIcd. The amines obtained show central neuroleptic effects only in subtoxic doses; they are also potent local anaesthetics and have significant spasmolytic activity of the neurotropic as well as musculotropic type.

An NMR relaxation study on the hydrogen dynamics in malonic acid

1987 ◽  
Vol 111 (3) ◽  
pp. 439-443 ◽  
Author(s):  
Stanislz.xlaw Idziak ◽  
Narcyz Piślewski
Keyword(s):  
Malonic Acid ◽  
Nmr Relaxation ◽  
Relaxation Study

scholarly journals Recent advances and prospects in the Zn-catalysed Mannich reaction

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9098-9111
Author(s):  
Salahudeen Shamna ◽  
C. M. A. Afsina ◽  
Rose Mary Philip ◽  
Gopinathan Anilkumar
Keyword(s):  
Carbonyl Compound ◽  
Secondary Amine ◽  
Mannich Reaction ◽  
Mannich Base ◽  
Mannich Reactions ◽  
Recent Advances ◽  
Primary Secondary Amine

Amino alkylation of an acidic α-proton of a carbonyl by formaldehyde and a primary/secondary amine or ammonia, affording a β-amino-carbonyl compound also known as a Mannich base is a valuable reaction. We focus on recent advances in Zn catalysed Mannich reactions.

Asymmetric Synthesis of α‐Difluorinated β‐Amino Sulfones via Detrifluoroacetylative Mannich Reactions

2021 ◽  
Author(s):  
Ziyi Li ◽  
Nana Wang ◽  
Haibo Mei ◽  
Hiroyuki Konno ◽  
Vadim A. Soloshonok ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Mannich Reactions
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