Self-Assembled Peptide–Lanthanide Nanoclusters for Safe Tumor Therapy: Overcoming and Utilizing Biological Barriers to Peptide Drug Delivery

ACS Nano ◽  
2018 ◽  
Vol 12 (2) ◽  
pp. 2017-2026 ◽  
Author(s):  
Jin Yan ◽  
Wangxiao He ◽  
Siqi Yan ◽  
Fan Niu ◽  
Tianya Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Therapy ◽  
Peptide Drug ◽  
Biological Barriers ◽  
Self Assembled

Self-Assembled Amphiphilic Starch Based Drug Delivery Platform: Synthesis, Preparation, and Interactions with Biological Barriers

2020 ◽  
Author(s):  
V. H. Giang Phan ◽  
Huu Thuy Trang Duong ◽  
Phu-Tri Tran ◽  
Thavasyappan Thambi ◽  
Duy-Khiet Ho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biological Barriers ◽  
Delivery Platform ◽  
Self Assembled

scholarly journals Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery

Theranostics ◽  
2018 ◽  
Vol 8 (19) ◽  
pp. 5320-5335 ◽  
Author(s):  
Zhenyuan Bian ◽  
Jin Yan ◽  
Simeng Wang ◽  
Yijie Li ◽  
Yi Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Peptide Drug ◽  
Biological Barriers ◽  
Small Nanoparticles

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Sally Sabra ◽  
Mona Abdelmoneem ◽  
Mahmoud Abdelwakil ◽  
Moustafa Taha Mabrouk ◽  
Doaa Anwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Anti Cancer ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Cancer Drug Delivery

The Role of Carrier Geometry in Overcoming Biological Barriers to Drug Delivery

2016 ◽  
Vol 22 (9) ◽  
pp. 1259-1273 ◽  
Author(s):  
Carolyn Jordan ◽  
Vladimir V. Shuvaev ◽  
Mark Bailey ◽  
Vladimir R. Muzykantov ◽  
Thomas D. Dziubla
Keyword(s):  
Drug Delivery ◽  
Biological Barriers

Hypoxia Responsive Drug Delivery Systems in Tumor Therapy

2016 ◽  
Vol 22 (19) ◽  
pp. 2808-2820 ◽  
Author(s):  
Houman Alimoradi ◽  
Siddharth S. Matikonda ◽  
Allan B. Gamble ◽  
Gregory I. Giles ◽  
Khaled Greish
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Delivery Systems

Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

2020 ◽  
Vol 20 (4) ◽  
pp. 271-287 ◽  
Author(s):  
Kuldeep Rajpoot
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Cancer Therapies ◽  
Medication Delivery ◽  
Lipid Nanocarriers ◽  
Targeted Drug ◽  
Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

A Triple-responsive Targeted Hybrid Liposomes with High MRI Performance for Tumor Diagnosis and Therapy

2021 ◽  
Author(s):  
Weihe Yao ◽  
Chenyu Liu ◽  
Ning Wang ◽  
Hengjun Zhou ◽  
Hailiang Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Delivery Systems ◽  
Tumor Diagnosis ◽  
Diagnosis And Therapy ◽  
Promising Strategy ◽  
Therapy And Diagnosis

The targeted multi-responsive drug delivery systems with MRI capacity were anticipated as a promising strategy for tumor therapy and diagnosis. Herein, we successfully synthesized anisamide-modified and non-modified UV/GSH-responsive molecules (10,10-NB-S-S-P-AA...

scholarly journals Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 122 ◽  
Author(s):  
Rebekah Omarkhail Elliott ◽  
Mei He
Keyword(s):  
Drug Delivery ◽  
Traffic Control ◽  
Information Transfer ◽  
Cancer Metastasis ◽  
Research Field ◽  
Blood Retinal Barrier ◽  
Biological Barriers ◽  
Diagnostic Role ◽  
Delivery Platform ◽  
Traffic Control System

Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup of nanovesicles called exosomes has been driving the research field to a new regime for understanding cellular communication. This exosome-dominated traffic control system has increased understanding of many diseases, including cancer metastasis, diabetes, and HIV. In addition to the important diagnostic role, exosomes are particularly attractive for drug delivery, due to their distinctive properties in cellular information transfer and uptake. Compared to viral and non-viral synthetic systems, the natural, cell-derived exosomes exhibit intrinsic payload and bioavailability. Most importantly, exosomes easily cross biological barriers, obstacles that continue to challenge other drug delivery nanoparticle systems. Recent emerging studies have shown numerous critical roles of exosomes in many biological barriers, including the blood–brain barrier (BBB), blood–cerebrospinal fluid barrier (BCSFB), blood–lymph barrier (BlyB), blood–air barrier (BAB), stromal barrier (SB), blood–labyrinth barrier (BLaB), blood–retinal barrier (BRB), and placental barrier (PB), which opens exciting new possibilities for using exosomes as the delivery platform. However, the systematic reviews summarizing such discoveries are still limited. This review covers state-of-the-art exosome research on crossing several important biological barriers with a focus on the current, accepted models used to explain the mechanisms of barrier crossing, including tight junctions. The potential to design and engineer exosomes to enhance delivery efficacy, leading to future applications in precision medicine and immunotherapy, is discussed.

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