Self-assembly of a metallo-peptide into a drug delivery system using a “switch on” displacement strategy

2018 ◽  
Vol 6 (48) ◽  
pp. 8228-8237 ◽  
Author(s):  
Priyadip Das ◽  
Ieshita Pan ◽  
Ehud Cohen ◽  
Meital Reches
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
Turn On ◽  
Delivery Platform ◽  
Self Assembled

Two newly designed tripeptides and their corresponding Cu2+ conjugates self-assemble into nanometric structures of different morphologies. These self-assembled metallo-peptide networks can serve as a drug delivery platform using a fluorescent-based "Turn-On" displacement strategy.

De novo design of Self-assembly Hydrogels based on Fmoc-diphenylalanine Providing with Drug Release

2021 ◽  
Author(s):  
Xiang Li ◽  
Huijun Zhang ◽  
Lingyan Liu ◽  
Chunyan Cao ◽  
Peng Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
De Novo ◽  
De Novo Design ◽  
Short Peptides ◽  
Self Assembled

The short peptides with self-assembled nanostructures are widely applied in the areas of drug delivery system and biomaterials. In this article, we create a new peptide-based hydrogelator (Fmoc-FFRRVR) based on...

scholarly journals Nanoparticulate targeted drug delivery systems - A Review

2020 ◽  
Vol 11 (2) ◽  
pp. 2505-2518
Author(s):  
Sindhuja Devaraj ◽  
Ganesh GNK
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Delivery Systems ◽  
Developing System ◽  
General Method

Nanoparticulate drug delivery system are the rapidly developing system, and nanoparticles are present in the size range of 1-100nm. Nanoparticles composed of various thermal, electrical, and optical property. Nanoparticles offers the potential advantages over the traditional dosage forms it is ascribable to the properties of nanoparticles. Nanoparticulate drug delivery system ensures the site-specific delivery of a drug(Targeting drug delivery) and aids in improving the efficacy of the new as well as old drugs and has the potential in crossing the various physiological barriers and also improves the therapeutic index of the drugs and increases the patient compliance. The objectives of this review is to classify the nanoparticles based on the different groups, surface properties of nanoparticles, describe the strategies of drug targeting, the necessity of nanoparticles their general method of preparation, different methods used in characterization, self- assembly and mechanism of drug release in a systemic manner. The potential advantages and limitations of various nanoparticulate drug delivery systems are also discussed elaborately.

scholarly journals A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer

2020 ◽  
Vol 8 (16) ◽  
pp. 3527-3533 ◽  
Author(s):  
Lairong Ding ◽  
Junwei Li ◽  
Changrong Wu ◽  
Feng Yan ◽  
Xuemei Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Triple Negative Breast Cancer ◽  
Triple Helix ◽  
Triple Negative ◽  
Breast Cancers ◽  
Self Assembled ◽  
Rna Triple Helix

A novel RNA-triple-helix hydrogel for treatment of triple negative breast cancers (TNBCs) by incorporating RNA-triple-helix and siRNA duplexes of CXCR4 into the same RNA nanoparticles was developed, without the synthetic polycationic reagents.

scholarly journals Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31581-31587 ◽  
Author(s):  
Lin Wang ◽  
Xuefeng Shi ◽  
Jian Zhang ◽  
Yuejun Zhu ◽  
Jinben Wang
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Ph Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembled

Supramolecular hydrogel, AGC16/NTS, was used to encapsulate hydrophobic drug curcumin (Cur), constructing a pH-responsive drug delivery system; the uptake of released Cur by cancer cells also occurred.

scholarly journals Injectable Drug Delivery System Based on in Situ Self‐Assembly of Liquid Star PEG‐PLGA

2020 ◽  
pp. 2000069
Author(s):  
Bat-Hen Eylon ◽  
Alona Shagan ◽  
Ayelet Shabtay-Orbach ◽  
Adi Gross ◽  
Boaz Mizrahi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
Injectable Drug

Highly uniform self-assembled microspheres from single macromolecule self-recognition for enhanced cancer immunotherapy

2020 ◽  
Vol 56 (64) ◽  
pp. 9190-9193
Author(s):  
Xin Shen ◽  
Zhenxia Zhou ◽  
Dongmei Qi ◽  
Yanchao Li ◽  
Zhiying Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Immunotherapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Self Recognition ◽  
Self Assembled ◽  
Local Drug Delivery System ◽  
Highly Uniform ◽  
Single Macromolecule

Self-assembled highly uniform microspheres has been developed as a local drug delivery system for effective synergistic immunotherapy.

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