Surfactant concentration effects on the microemulsion polymerization of vinyl acetate

Polymer ◽  
2005 ◽  
Vol 46 (9) ◽  
pp. 2900-2907 ◽  
Author(s):  
M. Gómez-Cisneros ◽  
M.E. Treviño ◽  
R.D. Peralta ◽  
M. Rabelero ◽  
E. Mendizábal ◽  
...  
Keyword(s):  
Vinyl Acetate ◽  
Surfactant Concentration ◽  
Microemulsion Polymerization ◽  
Concentration Effects

Surfactant Concentration Effects on the Aqueous Phase Polymerization of Vinyl Acetate

2009 ◽  
Vol 283-284 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Hugo Martínez-Gutiérrez ◽  
Víctor M. Ovando-Medina ◽  
René D. Peralta
Keyword(s):  
Vinyl Acetate ◽  
Aqueous Phase ◽  
Surfactant Concentration ◽  
Concentration Effects

Surfactant Concentration Effects on Micellar Properties

2012 ◽  
Vol 116 (3) ◽  
pp. 987-991 ◽  
Author(s):  
Arben Jusufi ◽  
David N. LeBard ◽  
Benjamin G. Levine ◽  
Michael L. Klein
Keyword(s):  
Surfactant Concentration ◽  
Concentration Effects ◽  
Micellar Properties

Microporous Polymeric Materials by Microemulsion Polymerization: Effect of Surfactant Concentration

Langmuir ◽  
1995 ◽  
Vol 11 (9) ◽  
pp. 3321-3326 ◽  
Author(s):  
T. H. Chieng ◽  
L. M. Gan ◽  
C. H. Chew ◽  
L. Lee ◽  
S. C. Ng ◽  
...  
Keyword(s):  
Surfactant Concentration ◽  
Polymeric Materials ◽  
Microemulsion Polymerization

Surfactant Concentration Effects on Nitroxide-Mediated Living Free Radical Miniemulsion Polymerization of Styrene

2002 ◽  
Vol 35 (18) ◽  
pp. 6915-6919 ◽  
Author(s):  
Gaofeng Pan ◽  
E. David Sudol ◽  
Victoria L. Dimonie ◽  
Mohamed S. El-Aasser
Keyword(s):  
Free Radical ◽  
Surfactant Concentration ◽  
Miniemulsion Polymerization ◽  
Concentration Effects

Surfactant concentration effects on amorphous PETG-montmorillonite layered silicate (MLS) nanocomposite films

2005 ◽  
Vol 54 (6) ◽  
pp. 875-881 ◽  
Author(s):  
Ajit Ranade ◽  
Nandika D'Souza ◽  
Christopher Thellen ◽  
Jo Ann Ratto
Keyword(s):  
Surfactant Concentration ◽  
Layered Silicate ◽  
Nanocomposite Films ◽  
Concentration Effects

scholarly journals Supersaturation and Solubilization upon In Vitro Digestion of Fenofibrate Type I Lipid Formulations: Effect of Droplet Size, Surfactant Concentration and Lipid Type

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1287
Author(s):  
Vladimir Katev ◽  
Sonya Tsibranska-Gyoreva ◽  
Zahari Vinarov ◽  
Slavka Tcholakova
Keyword(s):  
Droplet Size ◽  
Surfactant Concentration ◽  
Drop Size ◽  
Prediction Models ◽  
In Vitro Digestion ◽  
Oral Drug ◽  
Type I ◽  
Concentration Effects ◽  
Drug Solubilization

Lipid-based formulations (LBF) enhance oral drug absorption by promoting drug solubilization and supersaturation. The aim of the study was to determine the effect of the lipid carrier type, drop size and surfactant concentration on the rate of fenofibrate release in a bicarbonate-based in vitro digestion model. The effect of the lipid carrier was studied by preparing type I LBF with drop size ≈ 2 µm, based on medium-chain triglycerides (MCT), sunflower oil (SFO), coconut oil (CNO) and cocoa butter (CB). The drop size and surfactant concentration effects were assessed by studying MCT and SFO-based formulations with a drop size between 400 nm and 14 µm and surfactant concentrations of 1 or 10%. A filtration through a 200 nm filter followed by HPLC analysis was used to determine the aqueous fenofibrate, whereas lipid digestion was followed by gas chromatography. Shorter-chain triglycerides were key in promoting a faster drug release. The fenofibrate release from long-chain triglyceride formulations (SFO, CNO and CB) was governed by solubilization and was enhanced at a smaller droplet size and higher surfactant concentration. In contrast, supersaturation was observed after the digestion of MCT emulsions. In this case, a smaller drop size and higher surfactant had negative effects: lower peak fenofibrate concentrations and a faster onset of precipitation were observed. The study provides new mechanistic insights on drug solubilization and supersaturation after LBF digestion, and may support the development of new in silico prediction models.

Sign in / Sign up

Export Citation Format

Share Document