Surfactant Concentration Effects on Micellar Properties

2012 ◽  
Vol 116 (3) ◽  
pp. 987-991 ◽  
Author(s):  
Arben Jusufi ◽  
David N. LeBard ◽  
Benjamin G. Levine ◽  
Michael L. Klein
2002 ◽  
Vol 35 (18) ◽  
pp. 6915-6919 ◽  
Author(s):  
Gaofeng Pan ◽  
E. David Sudol ◽  
Victoria L. Dimonie ◽  
Mohamed S. El-Aasser

2005 ◽  
Vol 54 (6) ◽  
pp. 875-881 ◽  
Author(s):  
Ajit Ranade ◽  
Nandika D'Souza ◽  
Christopher Thellen ◽  
Jo Ann Ratto

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1287
Author(s):  
Vladimir Katev ◽  
Sonya Tsibranska-Gyoreva ◽  
Zahari Vinarov ◽  
Slavka Tcholakova

Lipid-based formulations (LBF) enhance oral drug absorption by promoting drug solubilization and supersaturation. The aim of the study was to determine the effect of the lipid carrier type, drop size and surfactant concentration on the rate of fenofibrate release in a bicarbonate-based in vitro digestion model. The effect of the lipid carrier was studied by preparing type I LBF with drop size ≈ 2 µm, based on medium-chain triglycerides (MCT), sunflower oil (SFO), coconut oil (CNO) and cocoa butter (CB). The drop size and surfactant concentration effects were assessed by studying MCT and SFO-based formulations with a drop size between 400 nm and 14 µm and surfactant concentrations of 1 or 10%. A filtration through a 200 nm filter followed by HPLC analysis was used to determine the aqueous fenofibrate, whereas lipid digestion was followed by gas chromatography. Shorter-chain triglycerides were key in promoting a faster drug release. The fenofibrate release from long-chain triglyceride formulations (SFO, CNO and CB) was governed by solubilization and was enhanced at a smaller droplet size and higher surfactant concentration. In contrast, supersaturation was observed after the digestion of MCT emulsions. In this case, a smaller drop size and higher surfactant had negative effects: lower peak fenofibrate concentrations and a faster onset of precipitation were observed. The study provides new mechanistic insights on drug solubilization and supersaturation after LBF digestion, and may support the development of new in silico prediction models.


2009 ◽  
Vol 283-284 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Hugo Martínez-Gutiérrez ◽  
Víctor M. Ovando-Medina ◽  
René D. Peralta

2021 ◽  
Vol 409 ◽  
pp. 126878
Author(s):  
M. Vijayanand ◽  
R. Varahamoorthi ◽  
P. Kumaradhas ◽  
S. Sivamani ◽  
Mithun V. Kulkarni

2017 ◽  
Vol 101 ◽  
pp. 02008
Author(s):  
Widia Yanti ◽  
Sugiatmo Kasmungin ◽  
Rabiatul Adawiyah ◽  
Blandina Kolanus

Polymer ◽  
2005 ◽  
Vol 46 (9) ◽  
pp. 2900-2907 ◽  
Author(s):  
M. Gómez-Cisneros ◽  
M.E. Treviño ◽  
R.D. Peralta ◽  
M. Rabelero ◽  
E. Mendizábal ◽  
...  

1983 ◽  
Vol 7 (2) ◽  
pp. 153-159 ◽  
Author(s):  
D. Fairhurst ◽  
M.P. Aronson ◽  
M.L. Ohm ◽  
E.D. Goddard

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