α-(phenylselanyl) acetophenone abolishes acute restraint stress induced-comorbid pain, depression and anxiety-related behaviors in mice

2018 ◽  
Vol 120 ◽  
pp. 112-120 ◽  
Author(s):  
Fernanda Severo Sabedra Sousa ◽  
Paloma Taborda Birmann ◽  
Renata Balaguez ◽  
Diego Alves ◽  
César Augusto Brüning ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Depression And Anxiety ◽  
Acute Restraint Stress

scholarly journals Protective Effects of Colomast®, a New Formulation of Adelmidrol and Sodium Hyaluronate, in a Mouse Model of Acute Restraint Stress

2020 ◽  
Vol 21 (21) ◽  
pp. 8136
Author(s):  
Ramona D’Amico ◽  
Rosalba Siracusa ◽  
Roberta Fusco ◽  
Marika Cordaro ◽  
Tiziana Genovese ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Cell Activation ◽  
Sodium Hyaluronate ◽  
Neutrophil Infiltration ◽  
Mast Cell Activation ◽  
Adhesive Tape ◽  
Protective Effects ◽  
Depression And Anxiety ◽  
Acute Restraint Stress ◽  
Apoptosis Pathways

Stress is generally defined as a homeostatic disruption from actual or implied threats and alters the homeostatic balance of different body organs, such as gastrointestinal function and the hypothalamic-pituitary-adrenal axis (HPA), inducing the release of glucocorticoid hormones. Stress is also known to be a risk factor for the development of depression and anxiety. However, until today there are no suitable therapies for treating of stress. The aim of this study was to explore the protective effect of Colomast®, a new preparation containing Adelmidrol, an enhancer of physiological of palmitoylethanolamide (PEA), and sodium hyaluronate in an animal model of immobilization stress. Acute restraint stress (ARS) was induced in mice by fixation for 2 h of the four extremities with an adhesive tape and Colomast® (20 mg/kg) was administered by oral gavage 30 min before the immobilization. Colomast® pre-treatment was able to decrease histopathological changes in the gastrointestinal tract, cytokines expression, neutrophil infiltration, mast cell activation, oxidative stress, as well as modulate nuclear factor NF-kB and apoptosis pathways after ARS induction. Moreover, Colomast® was able to restore tight junction in both ileum and hippocampus and cortex. Additionally, we demonstrated that Colomast® ameliorated depression and anxiety-related behaviours, and modulate inflammatory and apoptosis pathways also in brain after ARS induction. In conclusion, our results suggest Colomast® to be a potential approach to ARS.

Acute restraint stress has a similar effect on visceral sensitivity in different types of maternal deprivation in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A715-A715
Author(s):  
A ROSZTOCZY ◽  
S BRADESI ◽  
C BEAUFRAND ◽  
J FIORAMONTI ◽  
T WITTMANN ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Maternal Deprivation ◽  
Visceral Sensitivity ◽  
Acute Restraint Stress ◽  
Different Types

scholarly journals Acute Restraint Stress Alters Wheel-Running Behavior Immediately Following Stress and up to 20 Hours Later in House Mice

2016 ◽  
Vol 89 (6) ◽  
pp. 546-552 ◽  
Author(s):  
Jessica L. Malisch ◽  
Karen deWolski ◽  
Thomas H. Meek ◽  
Wendy Acosta ◽  
Kevin M. Middleton ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Wheel Running ◽  
House Mice ◽  
Acute Restraint Stress

Neuropeptidase activities in plasma after acute restraint stress. Interaction with cortico-limbic areas

2016 ◽  
Vol 28 (4) ◽  
pp. 239-243 ◽  
Author(s):  
Ana Belén Segarra ◽  
Joaquín Hernández ◽  
Isabel Prieto ◽  
Marc de Gasparo ◽  
Manuel Ramírez-Sánchez
Keyword(s):  
Restraint Stress ◽  
Enzymatic Activities ◽  
Stress Conditions ◽  
Acute Restraint Stress ◽  
Limbic Regions

ObjectiveTo evaluate the influence of acute restraint stress (ARS) on plasma enkephalinase and oxytocinase activities. ARS modifies basal activities in cortico-limbic regions of rats and induces changes in the correlations observed between these regions. The interactions between plasma and cortico-limbic activities will be also evaluated.MethodsEnkephalinase (AlaAP and LeuAP) and oxytocinase (P-LeuAP) activities were fluorometrically determined in plasma of control and stressed rats using aminoacyl-β-naphthylamides (aaNNap), AlaNNap and LeuNNap as substrates.ResultsNo differences in enzymatic activities were observed between control and stressed animals in plasma. In contrast, highly significant positive and negative correlations between plasma and cortico-limbic regions were demonstrated in controls. Stress conditions significantly alter the pattern of these correlations.ConclusionThe present results clearly support a connection between plasma and brain involving certain neuropeptidase activities that change under stress conditions.

Involvement of dorsal hippocampus glutamatergic and nitrergic neurotransmission in autonomic responses evoked by acute restraint stress in rats

Neuroscience ◽  
2014 ◽  
Vol 258 ◽  
pp. 364-373 ◽  
Author(s):  
T.B. Moraes-Neto ◽  
A.A. Scopinho ◽  
C. Biojone ◽  
F.M.A. Corrêa ◽  
L.B.M. Resstel
Keyword(s):  
Restraint Stress ◽  
Dorsal Hippocampus ◽  
Autonomic Responses ◽  
Acute Restraint Stress

scholarly journals Synergistic antidepressant- and anxiolytic-like effects of harmaline along with cinanserin in acute restraint stress-treated mice

2020 ◽  
Vol 238 (1) ◽  
pp. 259-269
Author(s):  
Sajedeh Mosaffa ◽  
Hanieh Ahmadi ◽  
Fatemeh Khakpai ◽  
Mohaddeseh Ebrahimi-Ghiri ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Restraint Stress ◽  
Acute Restraint Stress

Acute restraint stress alters food-foraging behavior in rats: Taking the easier Way while suffered

2019 ◽  
Vol 149 ◽  
pp. 184-193
Author(s):  
Bo-Xuan Tu ◽  
Lai-Fa Wang ◽  
Xiao-Lin Zhong ◽  
Zhao-Lan Hu ◽  
Wen-Yu Cao ◽  
...  
Keyword(s):  
Foraging Behavior ◽  
Restraint Stress ◽  
Acute Restraint Stress

81. The acute restraint stress cause changes in the phenotype of splenic lymphocytes, but no in dendritic cells

2014 ◽  
Vol 40 ◽  
pp. e24
Author(s):  
A.N. de Lima ◽  
E.K. Hamasato ◽  
D.G. da Cruz ◽  
J. Palermo-Neto ◽  
C.O. Massoco
Keyword(s):  
Dendritic Cells ◽  
Restraint Stress ◽  
Splenic Lymphocytes ◽  
Acute Restraint Stress
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