Opposite role of infralimbic and prelimbic cortex in the tachycardiac response evoked by acute restraint stress in rats

2009 ◽  
Vol 87 (11) ◽  
pp. 2601-2607 ◽  
Author(s):  
R.F. Tavares ◽  
F.M.A. Corrêa ◽  
L.B.M. Resstel
Keyword(s):  
Restraint Stress ◽  
Prelimbic Cortex ◽  
Acute Restraint Stress

scholarly journals Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats

2017 ◽  
Vol 175 ◽  
pp. 16-21 ◽  
Author(s):  
Josiane O. Duarte ◽  
Karina S. Gomes ◽  
Ricardo L. Nunes-de-Souza ◽  
Carlos C. Crestani
Keyword(s):  
Restraint Stress ◽  
Preoptic Area ◽  
Acute Restraint Stress ◽  
Neuroendocrine Responses

Role of the bed nucleus of the stria terminalis in the cardiovascular responses to acute restraint stress in rats

Stress ◽  
2009 ◽  
Vol 12 (3) ◽  
pp. 268-278 ◽  
Author(s):  
C. C. Crestani ◽  
F. H. F. Alves ◽  
R. F. Tavares ◽  
F. M. A. Corrêa
Keyword(s):  
Restraint Stress ◽  
Cardiovascular Responses ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Acute Restraint Stress

scholarly journals NEUROCHEMICAL ASSESSMENT AND BEHAVIORAL ROLE OF TUBEROINFUNDIBULAR PEPTIDE-39 IN ACUTE RESTRAINT STRESS-INDUCED DEPRESSION IN RATS.

2018 ◽  
Vol 11 (1) ◽  
pp. 332
Author(s):  
Sankar V ◽  
Ramanathan M ◽  
Venkatesh G
Keyword(s):  
Restraint Stress ◽  
Forced Swim Test ◽  
Gamma Aminobutyric Acid ◽  
Ambulatory Activity ◽  
Acute Restraint Stress ◽  
Behavioral Parameters ◽  
Potent Agonist ◽  
Tuberoinfundibular Peptide ◽  
Immobility Period

 Objective: Tuberoinfundibular peptide of 39 (TIP39) is a potent agonist to the parathyroid hormone 2 receptor (PTH2R) abundantly expressed in brain. The current study focused to evaluate the role of TIP39 in acute restraint stress (ARS)-induced depression model.Methods: Rats were exposed to ARS for 2 h to establish the depression and then subjected to open field and forced swim test (OFT and FST). TIP39 (1 and 10 nmol/rat) and HYWH (1 nmol/rat) are a PTH2R antagonist which was infused through intracerebroventricular route. Diazepam (2 mg/kg, i.p) was utilized as reference standard.Results: The results depict ARS significantly diminished the TIP39 expression in cerebral regions and causes depression-like behavior. TIP39 significantly decreased the immobility period in FST. In the OFT, TIP39 significantly increased the ambulatory activity and did not alter the rearing and grooming activity in comparison to ARS group. After TIP39 treatment, plasma noradrenaline levels were significantly increased, whereas the serotonin levels were unaltered. The corticosterone levels also decreased significantly. In rat brain tissues, TIP39 significantly reversed the abnormalities in glutamate and gamma-aminobutyric acid (GABA) level by ARS induction. In contrast, HYWH-treated rats did not show any significant variations in the neurochemical and behavioral parameters in comparison to ARS rats.Conclusion: Our reports submitted that the primary evidence depicting the stimulation of TIP39 expression could modulate the monoaminergic, GABAergic, and glutaminergic release with the support of hypothalamic-pituitary-adrenal axis that can be produced an antidepressant-like effect evident with the interactive study.

Evidence for a role of GABAA receptor in the acute restraint stress-induced enhancement of spatial memory

2007 ◽  
Vol 1181 ◽  
pp. 61-73 ◽  
Author(s):  
Gang Zheng ◽  
Xueping Zhang ◽  
Yaoming Chen ◽  
Yun Zhang ◽  
Wenjing Luo ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Gabaa Receptor ◽  
Restraint Stress ◽  
Acute Restraint Stress

scholarly journals The role of CRH in behavioral responses to acute restraint stress in zebrafish

2012 ◽  
Vol 36 (1) ◽  
pp. 176-182 ◽  
Author(s):  
Gabriele Ghisleni ◽  
Katiucia M. Capiotti ◽  
Rosane S. Da Silva ◽  
Jean P. Oses ◽  
Ângelo L. Piato ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Behavioral Responses ◽  
Acute Restraint Stress

Role of sex steroids in progesterone and corticosterone response to acute restraint stress in rats: sex differences

Stress ◽  
2013 ◽  
Vol 16 (4) ◽  
pp. 452-460 ◽  
Author(s):  
B. Kalil ◽  
C. M. Leite ◽  
M. Carvalho-Lima ◽  
J. A. Anselmo-Franci
Keyword(s):  
Sex Differences ◽  
Sex Steroids ◽  
Restraint Stress ◽  
Acute Restraint Stress ◽  
Corticosterone Response

scholarly journals Acute restraint stress induces endothelial dysfunction: role of vasoconstrictor prostanoids and oxidative stress

Stress ◽  
2015 ◽  
Vol 18 (2) ◽  
pp. 233-243 ◽  
Author(s):  
Ana P. P. Carda ◽  
Katia C. Marchi ◽  
Elen Rizzi ◽  
André S. Mecawi ◽  
José Antunes-Rodrigues ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Restraint Stress ◽  
Acute Restraint Stress ◽  
And Oxidative Stress

scholarly journals NEUROCHEMICAL ASSESSMENT AND BEHAVIORAL ROLE OF TUBEROINFUNDIBULAR PEPTIDE-39 IN ACUTE RESTRAINT STRESS-INDUCED DEPRESSION IN RATS.

2018 ◽  
Vol 11 (1) ◽  
pp. 332
Author(s):  
Sankar V ◽  
Ramanathan M ◽  
Venkatesh G
Keyword(s):  
Restraint Stress ◽  
Forced Swim Test ◽  
Gamma Aminobutyric Acid ◽  
Ambulatory Activity ◽  
Acute Restraint Stress ◽  
Behavioral Parameters ◽  
Potent Agonist ◽  
Tuberoinfundibular Peptide ◽  
Immobility Period

 Objective: Tuberoinfundibular peptide of 39 (TIP39) is a potent agonist to the parathyroid hormone 2 receptor (PTH2R) abundantly expressed in brain. The current study focused to evaluate the role of TIP39 in acute restraint stress (ARS)-induced depression model.Methods: Rats were exposed to ARS for 2 h to establish the depression and then subjected to open field and forced swim test (OFT and FST). TIP39 (1 and 10 nmol/rat) and HYWH (1 nmol/rat) are a PTH2R antagonist which was infused through intracerebroventricular route. Diazepam (2 mg/kg, i.p) was utilized as reference standard.Results: The results depict ARS significantly diminished the TIP39 expression in cerebral regions and causes depression-like behavior. TIP39 significantly decreased the immobility period in FST. In the OFT, TIP39 significantly increased the ambulatory activity and did not alter the rearing and grooming activity in comparison to ARS group. After TIP39 treatment, plasma noradrenaline levels were significantly increased, whereas the serotonin levels were unaltered. The corticosterone levels also decreased significantly. In rat brain tissues, TIP39 significantly reversed the abnormalities in glutamate and gamma-aminobutyric acid (GABA) level by ARS induction. In contrast, HYWH-treated rats did not show any significant variations in the neurochemical and behavioral parameters in comparison to ARS rats.Conclusion: Our reports submitted that the primary evidence depicting the stimulation of TIP39 expression could modulate the monoaminergic, GABAergic, and glutaminergic release with the support of hypothalamic-pituitary-adrenal axis that can be produced an antidepressant-like effect evident with the interactive study.

scholarly journals Acute restraint stress triggers progesterone withdrawal and endometrial breakdown and shedding through corticosterone stimulation in mouse menstrual-like model

Reproduction ◽  
2019 ◽  
pp. 149-161 ◽  
Author(s):  
Shu-Fang Wang ◽  
Xi-Hua Chen ◽  
Bin He ◽  
De-Dong Yin ◽  
Hai-Jun Gao ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Acute Stress ◽  
Regulatory Protein ◽  
Corticosterone Concentration ◽  
Factors Affecting ◽  
Acute Restraint Stress ◽  
Reproductive Axis ◽  
Cytochrome P450 Family ◽  
Experimental Findings

Stress impacts the reproductive axis at the level of the hypothalamus and the pituitary gland, which exert an effect on the ovary. Menstruation is regulated by the hypothalamic–pituitary–ovary (HPO) axis. However, the role of stress in menstruation remains unclear. The objective of this study was to explore the role of stress in endometrial breakdown and shedding, using the pseudopregnant mouse menstrual-like model. Female mice were mated with vasectomized males and labeled day 0.5, upon observation of a vaginal seminal plug. On day 3.5, decidualization was induced in pseudopregnant mice using arachis oil. On day 5.5, pseudopregnant mice with artificial decidualization were placed in restraint tubes for 3 h. The findings indicated that acute restraint stress resulted in the disintegration of the endometrium. While corticosterone concentration in the serum increased significantly due to restraint stress, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and progesterone (P4) levels in the serum decreased significantly. An endometrial histology examination indicated that progesterone implants may rescue P4 decline caused by acute stress and block endometrium breakdown and shedding. In addition, mice were treated with metyrapone, an inhibitor of corticosterone synthesis, 1 h prior to being subjected to restraint stress. Interestingly, metyrapone not only inhibited stress-induced endometrium breakdown and shedding, but also prevented stress-induced reduction of P4, LH and FSH. Furthermore, real-time PCR and western blot showed that mRNA and protein expression of CYP11A1 (cytochrome P450, family 11, subfamily A, polypeptide 1) and steroidogenic acute regulatory protein (StAR), the two rate-limiting enzymes for progesterone synthesis in the ovary, decreased following acute stress. But metyrapone prevented the reduction of StAR expression induced by restraint stress. Overall, this study revealed that acute stress results in an increase in corticosterone, which may inhibit LH and FSH release in the serum and CYP11A1 and StAR expression in the ovary, which finally leads to the breakdown and shedding of the endometrium. These experimental findings, based on the mouse model, may enable further understanding of the effects of stress on menstruation regulation and determine the potential factors affecting stress-associated menstrual disorders.

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