Injectable chitosan/β-glycerophosphate hydrogels with sustained release of BMP-7 and ornidazole in periodontal wound healing of class III furcation defects

2019 ◽  
Vol 99 ◽  
pp. 919-928 ◽  
Author(s):  
Shengqi Zang ◽  
Rui Mu ◽  
Feng Chen ◽  
Xiaocui Wei ◽  
Lei Zhu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sustained Release ◽  
Class Iii ◽  
Furcation Defects ◽  
Periodontal Wound Healing

Recombinant Human Osteogenic Protein-1 (OP-1) Stimulates Periodontal Wound Healing in Class III Furcation Defects

1998 ◽  
Vol 69 (2) ◽  
pp. 129-137 ◽  
Author(s):  
William V. Giannobile ◽  
Susan Ryan ◽  
Mei-Shu Shih ◽  
Dong Ling Su ◽  
Paul L. Kaplan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Class Iii ◽  
Furcation Defects ◽  
Osteogenic Protein ◽  
Periodontal Wound Healing

scholarly journals Periodontal wound healing following reciprocal autologous root transplantation in class III furcation defects

2017 ◽  
Vol 47 (6) ◽  
pp. 352 ◽  
Author(s):  
Naoshi Takeuchi ◽  
Yoshinori Shirakata ◽  
Yukiya Shinohara ◽  
Kotaro Sena ◽  
Kazuyuki Noguchi
Keyword(s):  
Wound Healing ◽  
Class Iii ◽  
Furcation Defects ◽  
Periodontal Wound Healing

scholarly journals Collagen Hydrogel Scaffold and Fibroblast Growth Factor-2 Accelerate Periodontal Healing of Class II Furcation Defects in Dog

2016 ◽  
Vol 10 (1) ◽  
pp. 347-359 ◽  
Author(s):  
Takehito Momose ◽  
Hirofumi Miyaji ◽  
Akihito Kato ◽  
Kosuke Ogawa ◽  
Takashi Yoshida ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Class Ii ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Hydrogel Scaffold ◽  
Collagen Hydrogel ◽  
Furcation Defects ◽  
Periodontal Wound Healing

Objective: Collagen hydrogel scaffold exhibits bio-safe properties and facilitates periodontal wound healing. However, regenerated tissue volume is insufficient. Fibroblast growth factor-2 (FGF2) up-regulates cell behaviors and subsequent wound healing. We evaluated whether periodontal wound healing is promoted by application of collagen hydrogel scaffold in combination with FGF2 in furcation defects in beagle dogs. Methods: Collagen hydrogel was fabricated from bovine type I collagen with an ascorbate-copper ion cross-linking system. Collagen hydrogel was mingled with FGF2 and injected into sponge-form collagen. Subsequently, FGF2 (50 µg)/collagen hydrogel scaffold and collagen hydrogel scaffold alone were implanted into class II furcation defects in dogs. In addition, no implantation was performed as a control. Histometric parameters were assessed at 10 days and 4 weeks after surgery. Result: FGF2 application to scaffold promoted considerable cell and tissue ingrowth containing numerous cells and blood vessel-like structure at day 10. At 4 weeks, reconstruction of alveolar bone was stimulated by implantation of scaffold loaded with FGF2. Furthermore, periodontal attachment, consisting of cementum-like tissue, periodontal ligament-like tissue and Sharpey’s fibers, was also repaired, indicating that FGF2-loaded scaffold guided self-assembly and then re-established the function of periodontal organs. Aberrant healing, such as ankylosis and root resorption, was not observed. Conclusion: FGF2-loaded collagen hydrogel scaffold possessed excellent biocompatibility and strongly promoted periodontal tissue engineering, including periodontal attachment re-organization.

scholarly journals Characterization and evaluation of graphene oxide scaffold for periodontal wound healing of class II furcation defects in dog

2018 ◽  
Vol Volume 13 ◽  
pp. 2365-2376 ◽  
Author(s):  
Kohei Kawamoto ◽  
Hirofumi Miyaji ◽  
Erika Nishida ◽  
Saori Miyata ◽  
Akihito Kato ◽  
...  
Keyword(s):  
Wound Healing ◽  
Graphene Oxide ◽  
Class Ii ◽  
Furcation Defects ◽  
Periodontal Wound Healing

Fabrication, characterization and in vivo evaluation of dexpanthenol sustained-release nanofibers for wound healing

2020 ◽  
Vol 91 ◽  
pp. 106827
Author(s):  
Maryam Najafiasl ◽  
Shahriar Osfouri ◽  
Reza Azin ◽  
Sasan Zaeri
Keyword(s):  
Wound Healing ◽  
Sustained Release ◽  
In Vivo Evaluation

scholarly journals Sustained Release of Insulin-Like Growth Factor-1 from Bombyx mori L. Silk Fibroin Delivery for Diabetic Wound Therapy

2021 ◽  
Vol 22 (12) ◽  
pp. 6267
Author(s):  
Meng-Jin Lin ◽  
Mei-Chun Lu ◽  
Hwan-You Chang
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Sustained Release ◽  
Silk Fibroin ◽  
Granulation Tissue ◽  
Release Rate ◽  
Insulin Like Growth Factor ◽  
Diabetic Wound ◽  
Diabetic Mice ◽  
Wound Therapy

The goals of this study are to develop a high purity patented silk fibroin (SF) film and test its suitability to be used as a slow-release delivery for insulin-like growth factor-1 (IGF-1). The release rate of the SF film delivering IGF-1 followed zero-order kinetics as determined via the Ritger and Peppas equation. The release rate constant was identified as 0.11, 0.23, and 0.09% h−1 at 37 °C for SF films loaded with 0.65, 6.5, and 65 pmol IGF-1, respectively. More importantly, the IGF-1 activity was preserved for more than 30 days when complexed with the SF film. We show that the IGF-1-loaded SF films significantly accelerated wound healing in vitro (BALB/3T3) and in vivo (diabetic mice), compared with wounds treated with free IGF-1 and an IGF-1-loaded hydrocolloid dressing. This was evidenced by a six-fold increase in the granulation tissue area in the IGF-1-loaded SF film treatment group compared to that of the PBS control group. Western blotting analysis also demonstrated that IGF-1 receptor (IGF1R) phosphorylation in diabetic wounds increased more significantly in the IGF-1-loaded SF films group than in other experimental groups. Our results suggest that IGF-1 sustained release from SF films promotes wound healing through continuously activating the IGF1R pathway, leading to the enhancement of both wound re-epithelialization and granulation tissue formation in diabetic mice. Collectively, these data indicate that SF films have considerable potential to be used as a wound dressing material for long-term IGF-1 delivery for diabetic wound therapy.

Polyvinyl Alcohol/Chitosan Composite Hydrogels with Sustained Release of Traditional Tibetan Medicine for Promoting Chronic Diabetic Wound Healing

2021 ◽  
Author(s):  
Xingyu Chen ◽  
Zuxin Wang ◽  
Shan Gao ◽  
Wanlin Zhang ◽  
Hanwen Gong ◽  
...  
Keyword(s):  
Wound Healing ◽  
Polyvinyl Alcohol ◽  
Sustained Release ◽  
Skin Diseases ◽  
Tibetan Medicine ◽  
Diabetic Wound ◽  
Composite Hydrogels ◽  
Diabetic Wound Healing ◽  
Traditional Tibetan Medicine ◽  
Chitosan Composite

The Tibetan eighteen flavor dangshen pills (TEP) are composed of 18 traditional Tibetan medicines, which are commonly used in the treatment of skin diseases in the Tibetan medicine system. They...

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