Application of Periodontal Tissue Engineering Using Enamel Matrix Derivative and a Human Fibroblast-Derived Dermal Substitute to Stimulate Periodontal Wound Healing in Class III Furcation Defects

2006 ◽  
Vol 77 (5) ◽  
pp. 790-799 ◽  
Author(s):  
Lawrence R. Hovey ◽  
Archie A. Jones ◽  
Michael McGuire ◽  
James T. Mellonig ◽  
John Schoolfield ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Enamel Matrix Derivative ◽  
Dermal Substitute ◽  
Periodontal Tissue ◽  
Enamel Matrix ◽  
Class Iii ◽  
Furcation Defects ◽  
Periodontal Wound Healing ◽  
Matrix Derivative

Effect of Enamel Matrix Derivative on Periodontal Wound Healing and Regeneration in an Osteoporotic Model

2014 ◽  
Vol 85 (11) ◽  
pp. 1603-1611 ◽  
Author(s):  
Richard J. Miron ◽  
Lingfei Wei ◽  
Shuang Yang ◽  
Oana M. Caluseru ◽  
Anton Sculean ◽  
...  
Keyword(s):  
Wound Healing ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Periodontal Wound Healing ◽  
Matrix Derivative

Effects of enamel matrix derivative on periodontal wound healing in an inflammatory environment in vitro

2011 ◽  
Vol 38 (5) ◽  
pp. 479-490 ◽  
Author(s):  
Marjan Nokhbehsaim ◽  
Jochen Winter ◽  
Birgit Rath ◽  
Andreas Jäger ◽  
Søren Jepsen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Periodontal Wound Healing ◽  
Matrix Derivative

scholarly journals Lesões em áreas de furca: fatores etiológicos, diagnóstico e tratamento

2020 ◽  
Vol 9 (6) ◽  
pp. 635-640
Author(s):  
Ariana Larissa de Moura Rodrigues ◽  
Ana Carolina de Sá Gomes Cruz Souza ◽  
Jéssica Gomes Alcoforado de Melo ◽  
Diego Moura Soares
Keyword(s):  
Systematic Review ◽  
Clinical Trial ◽  
Meta Analysis ◽  
Class Ii ◽  
Periodontal Treatment ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Furcation Defects ◽  
Furcation Involvement ◽  
Matrix Derivative

As lesões de furca ocorrem quando a doença periodontal atinge a área de bifurcação dos dentes multirradiculares causando a destruição óssea e perda de inserção no espaço inter-radicular. Existem diversos fatores etiológicos que influenciam no aparecimento dessas lesões e até os dias de hoje o tratamento desse tipo de injúria ainda é um desafio na clínica odontológica. O objetivo deste artigo foi listar, através de uma revisão da literatura, os fatores que influenciam na etiologia da lesão de furca, bem como o seu diagnóstico, prognóstico e tratamento. Fatores como características morfológicas do dente e raiz e deficiência no controle do biofilme, que podem contribuir para o seu aparecimento. Além de diversos tipos de procedimentos e técnicas têm sido propostas para o tratamento das lesões de furca, seja mais ou menos conservadores. Descritores: Defeitos da Furca; Diagnóstico; Doenças Periodontais. Referências Deliberador TM, Nagata MJH, Furlaneto FAC, Messora MR, Bosco AF, Garcia VG et al. Abordagem conservadora no tratamento dos defeitos de furca. RSBO. 2008;5(8):49-55. Silva GP, Sousa Neto AC, Pereira AFV, Alves CMC, Pereira ALA, Serra LLL. Classificação e tratamento das lesões de furca. Rev Ciênc Saúde. 2014;16(2):112-28. Nibali L, Zavattini A, Nagata K, Di Iorio A, Lin GH, Needleman I, et al. Tooth loss in molars with and without furcation involvement - a systematic review and meta-analysis. J Clin Periodontol. 2016;43(2):156-66. Artacho MCI, Arambulo GM. Defectos de furcación. Etiología, diagnóstico y tratamiento. Rev Estomatol Herediana. 2010;20(3):172-78. Pereira SG, Pinho MM, Almeida RF. Regeneração periodontal em lesões de furca–revisão da literatura. Rev port estomatol med dent cir maxilofac. 2012;53(2):123-32. Queiroz LA, Casarian RCV, Daddoub SM, Tatakis DN, Enilson AS, Kumar PS. Furcation Therapy with Enamel Matrix Derivative: Effects on the Subgingival Microbiome. J Periodontol. 2017;88(7):617-25. Vieira TR, Costa FO, Zenóbio EG, Soares RV. Anatomia radicular e suas implicações na terapêutica periodontal. Rev Periodontia 2009;19(1):7-13. Bower RC. Furcation morphology relative to periodontal treatment. Furcation root surface anatomy. J Periodontol. 1979;50(7):366-74. Newman M, Takei H, Klokkevold P, Carranza F. Periodontia clínica. ed. São Paulo: Elservier; 2016. Lindhe J, Karring T, Lang NP. Tratado de periodontia clínica e implantodontia oral. ed; Rio de Janeiro: Guanabara Koogan;2010. Hamp SE, Nyman S, Lindhe J. Periodontal treatment of multirroted teeth. Result after 5 years. J Clin Periodontol. 1975;2(3):126-35. Ramjford SP, Ash MM. Periodontology and Periodontics. Philadelphia: W.B. Saunders Co; 1979. Tarnow D, Fletcher P. Classification of the vertical component of furcation involvement. J Periodontol. 1984;55(5):283-84. Walter C, Weiger R, Zitman NU. Periodontal surgery in furcation-involved maxillary molars revisited: an introduction of guidelines for comprehensive treatment. Clin Oral Investig. 2011;15(1):9-20. Sallum AW, Cicareli AJ, Querido MRM, Bastos-Neto FVR. Periodontia e implantodontia - Soluções estéticas e recursos clínicos. Rio de Janeiro: Napoleão; 2010. Graziani F, Gennai S, Karapetsa D, Rosini S, Filice N, Gabriele M, et al. Clinical performance of access flap in the treatment of class II furcation defects. A systematic review and meta-analysis of randomized clinical trials. J Clin Periodontol. 2015;42(2):169-81. Svärdström G, Wennström JL. Periodontal treatment decisions for molars: an analysis of influencing factors and long-term outcome. J Periodontol. 2000;71(4):579-85. Huynh-Ba G, Kuonen P, Hofer D, Schmid J, Lang NP, Salvi GE. The effect of periodontal therapy on the survival rate and incidence of complications of multirooted teeth with furcation involvement after an observation period of at least 5 years: a systematic review. J Clin Periodontol. 2009;36(2):164-76. Shirakata Y, Miron RJ, Nakamura T, Sena K, Shinohara Y, Horai N et al. Effects of EMD liquid (Osteogain) on periodontal healing in class III furcation defects in monkeys. J Clin Periodontol. 2017;44(3):298-307. Meyle J, Gonzales JR, Bödeker RH, Hoffmann T, Richter S, Heinz B et al. A randomized clinical trial comparing enamel matrix derivative and  membrane treatment of buccal class II furcation involvement in mandibular molars. Part II: secondary outcomes. J Periodontol. 2004; 75(9):1188-95. Jenabian N, Haghanifar S, Ehsani H, Zahedi E, Haghpanah M. Guided tissue regeneration and platelet rich growth factor for the treatment of Grade II furcation defects: A randomized double-blinded clinical trial - A pilot study. Dent Res J (Isfahan). 2017;14(6):363-69. Kinaia M, Steiger J, Neely AL, Shah M, Bhola M. Treatment of class II molar furcation involvement: meta-analyses of re-entry results. J Periodontol. 2011;82(1):413-28. Correa A, Ferreira PS, Barboza R, Ribeiro EDP, Bittencourt S. Fatores que influenciam no sucesso da técnica do retalho posicionado coronalmente. Rev Bahiana Odonto; 2013;4(2):117-28. Jepsen S, Gennai S, Hirschfeld J, Kalemaj Z, Buti J, Graziani F. Regenerative surgical treatment of furcation defects: A systematic review and Bayesian network meta-analysis of randomized clinical trials. J Clin 2020;47(Suppl 22):352-74. Reddy MS, Aichelmann-Reidy ME, Avila-Ortiz G, Klokkevold PR, Murphy KG, Rosen PS, et al. Periodontal regeneration - furcation defects: a consensus report from the AAP Regeneration J Periodontol. 2015;86(2 Suppl):S131-3. Casarin RCV, Ribeiro EDP, Nociti-Jr FH, Sallum AW, Ambrosano GMB, Sallum EA, et al. Enamel matrix derivative proteins for the treatment of proximal class II furcation involvements: a prospective 24-month randomized clinical trial. J Clin Periodontol; 2010;37(12):1100-109. Hoffmann T, Richter S, Meyle J, Gonzales JR, Heinz B, Arjomand M et al. A randomized clinical multicentre trial comparing enamel matrix derivative and membrane treatment of buccal class II furcation involvement in mandibular molars. Part III: patient factors and treatment outcome. J Clin Periodontol. 2006;33(8):575-83.

scholarly journals Angiogenic Marker Alterations Following Enamel Matrix Derivative Treatment: A Human Study

2012 ◽  
Vol 2 (1) ◽  
pp. 8
Author(s):  
Onur Özçelik ◽  
Gülşah Seydaoğlu ◽  
Murat Cömert ◽  
Eftal Yılmaz ◽  
M. Cenk Haytaç
Keyword(s):  
Wound Healing ◽  
Inflammatory Infiltrate ◽  
Soft Tissues ◽  
Human Study ◽  
Gingival Tissue ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
And Control ◽  
Angiogenic Marker ◽  
Matrix Derivative

Aim: The aim of this immunohistochemical study was to assess the expression of angiogenic markers (vascular endothelial growth factor (VEGF) and microvessel density (MVD) in enamel matrix derivative (EMD) treated retromolar soft tissues to gain further insights into the biological mechanisms involved in wound healing and EMD treatment. Methodology: In twenty healthy volunteers, gingival biopsies were obtained from the distal wedge operations of test (EMD-applied) and control sites. EMD was applied into the test sites during the operation. At the 15th post-operative day, the sample sites were re-entered and gingival tissue samples were obtained from both test and control sites. A total of 80 samples for each sites were analyzed by immunohistochemistry for inflammatory infiltrate, expression of VEGF and MVD. Results: Despite similar post-operative inflammatory infiltrate, it was found that EMD- applied sites had statistically higher VEGF-A and VEGF-C expression and MVD compared to the controls on the 15th day. (p <0.0001 for each) Conclusions: This study supports that EMD has an angiogenic potential. The findings of this immunohistochemical analysis may help to gain insight into the angiogenic effects of EMD during the early phases of wound healing.  How to cite this article: Özçelik O, Seydaoğlu G, Cömert M, Yılmaz E, Haytaç MC. Angiogenic Marker Alterations Following Enamel Matrix Derivative Treatment: A Human Study. Int Dent Res 2012;2:8-16. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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