scholarly journals Characterization and evaluation of graphene oxide scaffold for periodontal wound healing of class II furcation defects in dog

2018 ◽  
Vol Volume 13 ◽  
pp. 2365-2376 ◽  
Author(s):  
Kohei Kawamoto ◽  
Hirofumi Miyaji ◽  
Erika Nishida ◽  
Saori Miyata ◽  
Akihito Kato ◽  
...  
Keyword(s):  
Wound Healing ◽  
Graphene Oxide ◽  
Class Ii ◽  
Furcation Defects ◽  
Periodontal Wound Healing

scholarly journals Collagen Hydrogel Scaffold and Fibroblast Growth Factor-2 Accelerate Periodontal Healing of Class II Furcation Defects in Dog

2016 ◽  
Vol 10 (1) ◽  
pp. 347-359 ◽  
Author(s):  
Takehito Momose ◽  
Hirofumi Miyaji ◽  
Akihito Kato ◽  
Kosuke Ogawa ◽  
Takashi Yoshida ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Class Ii ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Hydrogel Scaffold ◽  
Collagen Hydrogel ◽  
Furcation Defects ◽  
Periodontal Wound Healing

Objective: Collagen hydrogel scaffold exhibits bio-safe properties and facilitates periodontal wound healing. However, regenerated tissue volume is insufficient. Fibroblast growth factor-2 (FGF2) up-regulates cell behaviors and subsequent wound healing. We evaluated whether periodontal wound healing is promoted by application of collagen hydrogel scaffold in combination with FGF2 in furcation defects in beagle dogs. Methods: Collagen hydrogel was fabricated from bovine type I collagen with an ascorbate-copper ion cross-linking system. Collagen hydrogel was mingled with FGF2 and injected into sponge-form collagen. Subsequently, FGF2 (50 µg)/collagen hydrogel scaffold and collagen hydrogel scaffold alone were implanted into class II furcation defects in dogs. In addition, no implantation was performed as a control. Histometric parameters were assessed at 10 days and 4 weeks after surgery. Result: FGF2 application to scaffold promoted considerable cell and tissue ingrowth containing numerous cells and blood vessel-like structure at day 10. At 4 weeks, reconstruction of alveolar bone was stimulated by implantation of scaffold loaded with FGF2. Furthermore, periodontal attachment, consisting of cementum-like tissue, periodontal ligament-like tissue and Sharpey’s fibers, was also repaired, indicating that FGF2-loaded scaffold guided self-assembly and then re-established the function of periodontal organs. Aberrant healing, such as ankylosis and root resorption, was not observed. Conclusion: FGF2-loaded collagen hydrogel scaffold possessed excellent biocompatibility and strongly promoted periodontal tissue engineering, including periodontal attachment re-organization.

Recombinant Human Osteogenic Protein-1 (OP-1) Stimulates Periodontal Wound Healing in Class III Furcation Defects

1998 ◽  
Vol 69 (2) ◽  
pp. 129-137 ◽  
Author(s):  
William V. Giannobile ◽  
Susan Ryan ◽  
Mei-Shu Shih ◽  
Dong Ling Su ◽  
Paul L. Kaplan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Class Iii ◽  
Furcation Defects ◽  
Osteogenic Protein ◽  
Periodontal Wound Healing

scholarly journals Periodontal wound healing following reciprocal autologous root transplantation in class III furcation defects

2017 ◽  
Vol 47 (6) ◽  
pp. 352 ◽  
Author(s):  
Naoshi Takeuchi ◽  
Yoshinori Shirakata ◽  
Yukiya Shinohara ◽  
Kotaro Sena ◽  
Kazuyuki Noguchi
Keyword(s):  
Wound Healing ◽  
Class Iii ◽  
Furcation Defects ◽  
Periodontal Wound Healing

Treatment of class II furcation defects with autogenous bone graft associated with Bichat’s fat pad: case report

RSBO ◽  
2017 ◽  
Vol 1 (2) ◽  
pp. 114
Author(s):  
Priscila Alves Teixeira ◽  
Carmen L. Mueller Storrer ◽  
Felipe Rychuv Santos ◽  
Aline Monise Sebastiani ◽  
Tatiana Miranda Deliberador
Keyword(s):  
Case Report ◽  
Bone Graft ◽  
Low Cost ◽  
Class Ii ◽  
Autogenous Bone Graft ◽  
Surgical Reconstruction ◽  
Autogenous Bone ◽  
Fat Pad ◽  
Furcation Defects ◽  
Maxillary Tuberosity

The periodontal treatment of teeth with furcation defect is clinically challenging. In cases of class II furcation defects, the regenerative surgery shows low morbidity and good prognosis when correctly indicated. The aim of the presentstudy is to report a treatment option for class II furcation defect through autogenous bone graft associated with the Bichat’s fat pad. Case report: A 59-year-old female patient was diagnosed with class II furcation defect in the left mandibular first molar. The treatment comprised surgical reconstruction of the defect with a combination of maxillary tuberosity bone graft and Bichat’s fat pad. The clinical and radiographic follow-up of 180 days showed bone formation inthe furcation area and absence of probing depth. Conclusion: An association of autogenous graft form the maxillary tuberosity with a Bichat’s fat pad proved to be a safe, low cost, and effective therapy for the regenerative treatment of class II furcation.

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