Fabrication, characterization and in vivo evaluation of dexpanthenol sustained-release nanofibers for wound healing

2020 ◽  
Vol 91 ◽  
pp. 106827
Author(s):  
Maryam Najafiasl ◽  
Shahriar Osfouri ◽  
Reza Azin ◽  
Sasan Zaeri
Keyword(s):  
Wound Healing ◽  
Sustained Release ◽  
In Vivo Evaluation

In vitro and in vivo evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207

2021 ◽  
Vol 26 (3) ◽  
pp. 349-361
Author(s):  
Napoleon-Nikolaos Vrettos ◽  
Peng Wang ◽  
Yan Zhou ◽  
Clive J. Roberts ◽  
Jinyi Xu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Antihypertensive Drug ◽  
The Novel ◽  
In Vivo Evaluation

In vivo evaluation of risperidone-SAIB in situ system as a sustained release delivery system in rats

2008 ◽  
Vol 68 (2) ◽  
pp. 422-429 ◽  
Author(s):  
Yaxin Lu ◽  
Xing Tang ◽  
Yue Cui ◽  
Yu Zhang ◽  
Feng Qin ◽  
...  
Keyword(s):  
Sustained Release ◽  
Delivery System ◽  
In Vivo Evaluation

SUSTAINED RELEASE HYDROPHILIC MATRICES BASED ON XANTHAN GUM AND HYDROXYPROPYL METHYLCELLULOSE: DEVELOPMENT, OPTIMIZATION, IN VITRO AND IN VIVO EVALUATION

2010 ◽  
Vol 2 ◽  
pp. 89-103
Author(s):  
Muhammad Sajid Hamid Akash . ◽  
Ikram Ullah Khan . ◽  
Syed Nisar Hussain Shah . ◽  
Sajid Asghar . ◽  
Asif massud . ◽  
...  
Keyword(s):  
Sustained Release ◽  
Xanthan Gum ◽  
Hydroxypropyl Methylcellulose ◽  
In Vivo Evaluation ◽  
Hydrophilic Matrices

Taro-corms mucilage-alginate microspheres for the sustained release of pregabalin: In vitro & in vivo evaluation

2019 ◽  
Vol 139 ◽  
pp. 1191-1202 ◽  
Author(s):  
Shazia Akram Ghumman ◽  
Sajid Bashir ◽  
Sobia Noreen ◽  
Abdul Muqeet Khan ◽  
Muhammad Zubair Malik
Keyword(s):  
Sustained Release ◽  
In Vivo Evaluation

scholarly journals Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 447 ◽  
Author(s):  
Fabian Ávila-Salas ◽  
Adolfo Marican ◽  
Soledad Pinochet ◽  
Gustavo Carreño ◽  
Oscar Valdés ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sustained Release ◽  
Bioactive Compounds ◽  
Target Therapy ◽  
Dicarboxylic Acids ◽  
Skin Wound ◽  
Dynamics Simulation ◽  
Skin Wound Healing

This research proposes the rational modeling, synthesis and evaluation of film dressing hydrogels based on polyvinyl alcohol crosslinked with 20 different kinds of dicarboxylic acids. These formulations would allow the sustained release of simultaneous bioactive compounds including allantoin, resveratrol, dexpanthenol and caffeic acid as a multi-target therapy in wound healing. Interaction energy calculations and molecular dynamics simulation studies allowed evaluating the intermolecular affinity of the above bioactive compounds by hydrogels crosslinked with the different dicarboxylic acids. According to the computational results, the hydrogels crosslinked with succinic, aspartic, maleic and malic acids were selected as the best candidates to be synthesized and evaluated experimentally. These four crosslinked hydrogels were prepared and characterized by FTIR, mechanical properties, SEM and equilibrium swelling ratio. The sustained release of the bioactive compounds from the film dressing was investigated in vitro and in vivo. The in vitro results indicate a good release profile for all four analyzed bioactive compounds. More importantly, in vivo experiments suggest that prepared formulations could considerably accelerate the healing rate of artificial wounds in rats. The histological studies show that these formulations help to successfully reconstruct and thicken epidermis during 14 days of wound healing. Moreover, the four film dressings developed and exhibited excellent biocompatibility. In conclusion, the novel film dressings based on hydrogels rationally designed with combinatorial and sustained release therapy could have significant promise as dressing materials for skin wound healing.

scholarly journals Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets

2015 ◽  
Vol 10 (3) ◽  
pp. 239-246 ◽  
Author(s):  
Pankaj Kumar ◽  
Ashok Laxmanrao Ganure ◽  
Bharat Bhushan Subudhi ◽  
Shubhanjali Shukla ◽  
Pooja Upadhyay
Keyword(s):  
Sustained Release ◽  
Graft Copolymer ◽  
In Vivo Evaluation ◽  
Salbutamol Sulphate ◽  
Sustained Release Tablets
Sign in / Sign up

Export Citation Format

Share Document