Methionine synthase A2756G transition might be a risk factor for male infertility: Evidences from seven case-control studies

2016 ◽  
Vol 425 ◽  
pp. 1-10 ◽  
Author(s):  
Mohammad Karimian ◽  
Abasalt Hosseinzadeh Colagar
Keyword(s):  
Risk Factor ◽  
Male Infertility ◽  
Case Control ◽  
Methionine Synthase ◽  
Case Control Studies

scholarly journals Psychological Autopsy Studies of Suicide in South East Asia

2021 ◽  
pp. 025371762110336
Author(s):  
S.M. Yasir Arafat ◽  
Vikas Menon ◽  
Natarajan Varadharajan ◽  
Sujita Kumar Kar
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
East Asia ◽  
Psychiatric Disorders ◽  
Study Design ◽  
Case Control ◽  
Stressful Life ◽  
South East Asia ◽  
Psychological Autopsy ◽  
Case Control Studies

Background: Psychiatric disorders have been identified as an important risk factor for suicide. However, different psychological autopsy studies have revealed different prevalences at different times and places. Objective: We aimed to see the distribution of psychological autopsy studies and the prevalence of mental disorders among suicides and identify major risk factors in Southeast Asian countries. Method: We scrutinized psychological autopsy studies published in the World Health Organization (WHO) South-East Asia (SEA) region countries. We also searched the available bibliographies to identify the studies in the region so that all the possible articles could be included. Results: Out of the 11 countries, 14 psychological autopsy studies were identified in five SEA countries (Bangladesh [1], India [9], Indonesia [1], Nepal [1], and Sri Lanka [2]). Seven studies (50%) used a case-control study design, and eight (57.1%) were carried out in urban settings. The prevalence of psychiatric disorders in case-control studies was from 37% to 88%. Stressful life event was identified as a major risk factor in all the case-control studies. Conclusion: Psychological autopsy studies have not been conducted in 6 out of 11 countries of the SEA region. The presence of pre-existing psychiatric morbidity and stressful life events were the two most common risk factors noted across settings, even though there is wide heterogeneity in samples, study design, instruments, and study settings.

Vitamin D deficiency as a risk factor for thyroid cancer: A meta-analysis of case-control studies

Nutrition ◽  
2019 ◽  
Vol 57 ◽  
pp. 5-11 ◽  
Author(s):  
Junyu Zhao ◽  
Haipeng Wang ◽  
Zhongwen Zhang ◽  
Xiaojun Zhou ◽  
Jinming Yao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Thyroid Cancer ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Is Opium a Real Risk Factor for Esophageal Cancer or Just a Methodological Artifact? Hospital and Neighborhood Controls in Case-Control Studies

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e32711 ◽  
Author(s):  
Ramin Shakeri ◽  
Farin Kamangar ◽  
Dariush Nasrollahzadeh ◽  
Mehdi Nouraie ◽  
Hooman Khademi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Risk Factor ◽  
Case Control ◽  
Case Control Studies ◽  
Real Risk ◽  
Methodological Artifact

The ‘well control’ artefact in case/control studies of specific psychiatric disorders

1989 ◽  
Vol 19 (3) ◽  
pp. 737-742 ◽  
Author(s):  
Sharon Schwartz ◽  
Bruce G. Link
Keyword(s):  
Risk Factor ◽  
Psychiatric Disorders ◽  
Group Selection ◽  
Case Control ◽  
Control Group ◽  
Case Control Studies ◽  
Suggested Approach ◽  
Well Control ◽  
Risk Factor Assessment ◽  
Intuitive Appeal

SynopsisAn appropriate choice of controls in case/control studies of specific psychiatric disorders is crucial for valid risk-factor assessment. One suggested approach to control-group selection, the use of a well control group, is the focus of this paper. While using well controls has intuitive appeal, this paper shows that such a procedure can lead to ambiguous and biased results.

scholarly journals Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Fereshteh Aliakbari ◽  
Farkhondeh Pouresmaeili ◽  
Nahal Eshghifar ◽  
Zahra Zolghadr ◽  
Faezeh Azizi
Keyword(s):  
Male Infertility ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Case Control ◽  
Inclusion Criteria ◽  
Case Control Studies ◽  
Crude Odds Ratio ◽  
Mthfr Polymorphism ◽  
Gene Environment ◽  
The Relationship

Abstract Background and objectives One of the possible male sterility risk factors are polymorphisms of Methylenetetrahydrofolate reductase (MTHFR). However, the epidemiologic investigations described inconsistent results regarding MTHFR polymorphism and the risk of male infertility. For that reason, we carried out a meta-analysis of published case-control studies to re-examine the controversy. Methods Electronic searches of Cochrane, EMBASE, Google Scholar, and PubMed were conducted to select eligible studies for this meta-analysis (updated to May 2019). According to our exclusion and inclusion criteria, only high-quality studies that remarked the association between MTHFR polymorphisms and male infertility risk were included. The Crude odds ratio (OR) with a confidence interval of 95% (CI) was used to assess the relationship between MTHFR polymorphism and male infertility risk. Results Thirty-four case-control studies with 9662 cases and 9154 controls concerning 677C/T polymorphism and 22 case-control studies with 5893 cases and 6303 controls concerning 1298A/C polymorphism were recruited. Both MTHFR polymorphisms had significant associations with male infertility risk (CT + TT vs. CC: OR = 1.37, 95% CI: 1.21–1.55, P = 0.00, I2 = 41.9%); (CC vs. CA + AA: OR = 0.82, 95% CI: 0.52–1.30, P = 0.04, I2 = 50.1%). Further, when stratified by ethnicity, the significant association results were observed in Asians and Caucasians for 677C/T and just Asians for 1298A/C. Conclusions Some of MTHFR polymorphisms like MTHFR 677C > T are associated with an elevated male infertility risk. To confirm our conclusion and to provide more accurate and complete gene-environment communication with male infertility risk, more analytical studies are needed.

Su1836 Gastrectomy Is Not a Risk Factor for Pancreatic Cancer: A Meta-Analysis of Case-Control Studies

2014 ◽  
Vol 146 (5) ◽  
pp. S-1048-S-1049
Author(s):  
Rajan Kanth ◽  
Naga Swetha Samji ◽  
Ramon E. Rivera ◽  
Mainor R. Antillon ◽  
Praveen K. Roy
Keyword(s):  
Pancreatic Cancer ◽  
Risk Factor ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Smoking is a risk factor for multiple sclerosis: a metanalysis

2007 ◽  
Vol 13 (5) ◽  
pp. 610-615 ◽  
Author(s):  
C.H. Hawkes
Keyword(s):  
Multiple Sclerosis ◽  
Risk Factor ◽  
Data Collection ◽  
Cigarette Smoking ◽  
Statistical Methods ◽  
Disease Onset ◽  
Case Control ◽  
Case Control Studies ◽  
Indirect Association ◽  
Rate Ratios

Several case control studies have probed a link between cigarette smoking and subsequent multiple sclerosis (MS). Data collection and statistical methods have varied, and frequently, case numbers have been small. Publications relating to MS and smoking are reviewed and combined where comparable methods have been used. Metanalysis of six informative studies show significantly elevated odds or rate ratios, ranging from 1.22 to 1.51, depending on the method of analysis, confirming that the risk of MS is increased for those who smoke prior to disease onset, as measured by commencement of symptoms. A variety of direct causative mechanisms are discussed, but an indirect association through health adverse conduct is favoured. Multiple Sclerosis 2007; 13: 610-615. http://msj.sagepub.com

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