Vitamin D deficiency as a risk factor for thyroid cancer: A meta-analysis of case-control studies

Nutrition ◽  
2019 ◽  
Vol 57 ◽  
pp. 5-11 ◽  
Author(s):  
Junyu Zhao ◽  
Haipeng Wang ◽  
Zhongwen Zhang ◽  
Xiaojun Zhou ◽  
Jinming Yao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Thyroid Cancer ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Association between vitamin D deficiency and risk of thyroid cancer: a case–control study and a meta-analysis

2018 ◽  
Vol 41 (10) ◽  
pp. 1199-1210 ◽  
Author(s):  
M.-J. Hu ◽  
Q. Zhang ◽  
L. Liang ◽  
S.-Y. Wang ◽  
X.-C. Zheng ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Cancer ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study

scholarly journals Vitamin D in Head and Neck Cancer: a Systematic Review

2020 ◽  
Vol 23 (1) ◽  
Author(s):  
Antti Mäkitie ◽  
Iida Tuokkola ◽  
Göran Laurell ◽  
Outi Mäkitie ◽  
Kerry Olsen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Vitamin D Deficiency ◽  
Neck Cancer ◽  
Cancer Diagnosis ◽  
Case Control ◽  
Healthy Population ◽  
Inverse Association ◽  
Case Control Studies

Abstract Purpose of review Observational studies have shown that serum 25-OH vitamin D [25(OH)D] is inversely associated with overall cancer risk in many malignancies. We performed a systematic literature review to determine whether vitamin D deficiency is related to head and neck cancer (HNC) etiology and outcome. Recent findings The search yielded five prospective studies reporting 25(OH)D levels prior to cancer diagnosis and their effect on the risk of HNC. Eight studies were cross-sectional or case-control studies, in which 25(OH)D levels were only measured after cancer diagnosis. Two studies found an inverse association between 25(OH)D level and HNC risk, while two other prospective cohort studies demonstrated no connection between 25(OH)D and HNC risk. Several studies reported cancer patients to have significantly lower 25(OH)D levels than controls. Associations between 25(OH)D and prognosis and mortality were variable. Summary The link between vitamin D and HNC has so far only been investigated in a few observational, prospective, and case-control studies. Vitamin D deficiency may be more common in HNC patients than in the healthy population. There is no evidence for a causal relationship. Further studies are needed to evaluate whether low 25(OH)D concentrations play a role in the development or outcome of HNCs.

Su1836 Gastrectomy Is Not a Risk Factor for Pancreatic Cancer: A Meta-Analysis of Case-Control Studies

2014 ◽  
Vol 146 (5) ◽  
pp. S-1048-S-1049
Author(s):  
Rajan Kanth ◽  
Naga Swetha Samji ◽  
Ramon E. Rivera ◽  
Mainor R. Antillon ◽  
Praveen K. Roy
Keyword(s):  
Pancreatic Cancer ◽  
Risk Factor ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Periodontal disease as a risk factor for adverse pregnancy outcomes: a systematic review and meta-analysis of case–control studies

Odontology ◽  
2011 ◽  
Vol 100 (2) ◽  
pp. 232-240 ◽  
Author(s):  
Stefano Corbella ◽  
Silvio Taschieri ◽  
Luca Francetti ◽  
Francesca De Siena ◽  
Massimo Del Fabbro
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Periodontal Disease ◽  
Pregnancy Outcomes ◽  
Meta Analysis ◽  
Case Control ◽  
Adverse Pregnancy Outcomes ◽  
Case Control Studies ◽  
Adverse Pregnancy

PT05.4: Is Vitamin D Deficiency a Risk Factor for Hip Fracture? A Case-Control Study

2016 ◽  
Vol 35 ◽  
pp. S31-S32
Author(s):  
M.J. Martínez-Ramírez ◽  
C. Tenorio Jiménez ◽  
I. Carrillo-González ◽  
C. Arraiza Irigoyen ◽  
S. Salcedo Crespo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Hip Fracture ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Does Vitamin D Deficiency in Different Periods of Gestation Have the Same Effect on Preterm Birth? A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
bin Yi ◽  
Rui-han Lian ◽  
Ping-an Qi ◽  
Tao Yuan ◽  
Pei-jing Yan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Preterm Birth ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Second Trimester ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Vitamin D Levels

Abstract Background: Current studies suggest that vitamin D deficiency during pregnancy can produce a certain effect for preterm birth, but there is no research showing whether vitamin D deficiency has a consistent effect in different pregnancies; thus, we conducted a systematic review and meta-analysis of 24 observational studies, grouping them according to the gestational age at the time of serum sampling, to investigate whether vitamin D deficiency in different periods of gestation has different effects on preterm birth and to provide an evidence-based basis for pregnant women to measure and supplement vitamin D. Methods: The databases PubMed-Medline, EMBASE, the Cochrane Library, Web of Science, EBSCO, CBM, and CNKI were searched until July 2019. Two researchers independently assessed the eligibility and quality of studies, and STATA 12.0 software was used for meta-analysis. Result: Seven cohort studies, 13 case-control studies, and four cross-sectional studies were included from 2500 articles by inclusion and exclusion criteria. After adjusting for age, race, and other confounding factors, meta-analysis results showed that vitamin D deficiency in the first trimester, the second trimester and the third trimester did not increase the risk of preterm birth (odds ratio (OR) = 1.01, 95% confidence interval (CI) (0.88, 1.16), P = 0.867; OR = 1.12, 95%CI (0.92, 1.37), P = 0.249; OR = 1.05, 95%CI (0.87, 1.27), P = 0.602). However, there was moderate heterogeneity in the study of vitamin D deficiency in the second trimester, and subgroup analysis suggested that vitamin D deficiency in the second trimester may increase the risk of preterm birth (OR = 1.33, 95%CI (1.15, 1.54), P = 0.000). A sensitivity analysis of the second trimester showed that excluding any one study did not significantly change the results. Conclusions: Vitamin D deficiency in early and late pregnancy may not be associated with preterm birth, while vitamin D deficiency in middle pregnancy is likely to have an important effect on preterm birth. Vitamin D levels should be measured in the second trimester of pregnancy, and vitamin D supplements should be provided if necessary.

scholarly journals Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Danyal Imani ◽  
Bahman Razi ◽  
Morteza Motallebnezhad ◽  
Ramazan Rezaei
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Gene Polymorphisms ◽  
Genetic Model ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Asian Populations ◽  
Increased Risk ◽  
Apai Polymorphism

Abstract Background The association between the Vitamin D Receptor (VDR) gene polymorphism and the risk of Multiple sclerosis (MS) has been evaluated in several researches. However, the findings were inconsistent and inconclusive. Therefore, we set out a meta-analysis of all eligible published case-control studies to obtain an exact evaluation of the association between VDR gene polymorphisms and MS. Method All relevant studies reporting the association between the VDR gene FokI (rs2228570), or/and TaqI (rs731236) or/and BsmI (rs1544410) or/and ApaI (rs7975232) polymorphisms and susceptibility to MS published up to May, 2019 were identified by comprehensive systematic search in the electronic database of web of science, Scopus, and PubMed. After that, the strength of association between VDR gene polymorphisms and susceptibility to MS was evaluated by odds ratio (OR) and 95% confidence interval (CI). Results A total of 30 case–control studies were included in the meta-analysis. The overall results suggested a significant association between TaqI polymorphism and MS risk under heterozygote genetic model (OR = 1.27, 95%CI = 1.01–1.59, random effect). Moreover, the pooled results of subgroup analysis declined presence of significant association under all defined genetic model. In subgroup analysis, BsmI polymorphisms was associated with increased risk of MS under recessive model in Asian populations. On the other hand, ApaI polymorphism was associated with decreased risk of MS under recessive and aa vs. AA model in Asian populations. Conclusion This meta-analysis suggested a significant association between TaqI polymorphism and MS susceptibility. Furthermore, BsmI polymorphism was associated with increased risk of MS in Asian populations. In contrast, ApaI polymorphism was associated with decreased risk of MS in Asian populations. Future large-scale studies on gene–environment and gene–gene interactions are required to estimate risk factors and assist early diagnosis of patients at high risk for MS.

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