Sex-specific effects of chronic antidepressant treatment in middle-aged rats: impact of citalopram on cognition and depressive-like behaviors

Maturitas ◽  
2015 ◽  
Vol 81 (1) ◽  
pp. 159 ◽  
Author(s):  
Ryoko Hiroi ◽  
Alicia M. Quihuis ◽  
Courtney N. Lavery ◽  
Steven J. Granger ◽  
Giulia Weyrich ◽  
...  
Keyword(s):  
Antidepressant Treatment ◽  
Aged Rats ◽  
Middle Aged ◽  
Specific Effects

scholarly journals Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
José Jaime Herrera-Pérez ◽  
Alonso Fernández-Guasti ◽  
Lucía Martínez-Mota
Keyword(s):  
Selective Serotonin Reuptake Inhibitors ◽  
Antidepressant Treatment ◽  
Brain Regions ◽  
Dorsal Raphe ◽  
Lateral Septum ◽  
Male Rats ◽  
Aged Rats ◽  
Middle Aged ◽  
Age Related ◽  
Dorsal Raphé

In preclinical and clinical studies aging has been associated with a deteriorated response to antidepressant treatment. We hypothesize that such impairment is explained by an age-related decrease in brain serotonin transporter (SERT) expression associated with low testosterone (T) levels. The objectives of this study were to establish (1) if brain SERT expression is reduced by aging and (2) if the SERT expression in middle-aged rats is increased by T-restitution. Intact young rats (3–5 months) and gonad-intact middle-aged rats with or without T-restitution were used. The identification of the brain SERT expression was done by immunofluorescence in prefrontal cortex, lateral septum, hippocampus, and raphe nuclei. An age-dependent reduction of SERT expression was observed in all brain regions examined, while T-restitution recovered the SERT expression only in the dorsal raphe of middle-aged rats. This last action seems relevant since dorsal raphe plays an important role in the antidepressant action of selective serotonin reuptake inhibitors. All data suggest that this mechanism accounts for the T-replacement usefulness to improve the response to antidepressants in the aged population.

Protective Effects of Exercise Training Against Aged Induced the Reduction of Cardiac Angiogenic Capacity in Middle Aged Rats

2020 ◽  
Vol 04 (01) ◽  
Author(s):  
Titiporn Mekrungruangwong ◽  
Pimpetch Kasetsuwan ◽  
Sheepsumon Viboolvorakul ◽  
Suthiluk Patumraj
Keyword(s):  
Exercise Training ◽  
Protective Effects ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Effects of Food Restriction on Mechanical Properties of Arterial System in Adult and Middle-Aged Rats

1999 ◽  
Vol 54 (10) ◽  
pp. B441-B447 ◽  
Author(s):  
K.-C. Chang ◽  
C.-Y. Chow ◽  
Y.-I. Peng ◽  
T.-J. Chen ◽  
Y.-F. Tsai
Keyword(s):  
Mechanical Properties ◽  
Food Restriction ◽  
Arterial System ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Age-Related Effects on Right Femoral Bone of Male Wistar Rats: A Morphometric and Biomechanical Study

2021 ◽  
Author(s):  
Sheila Martins Puelker ◽  
Sonia Regina Ribeiro de Castro ◽  
Romeu Rodrigues de Souza ◽  
Laura Beatriz Mesiano Maifrino ◽  
Ricardo Aparecido Baptista Nucci ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Wistar Rats ◽  
Female Rats ◽  
Male Rats ◽  
Aged Rats ◽  
Femoral Bone ◽  
Middle Aged ◽  
Left Femur ◽  
Bone Stiffness ◽  
The Right

Abstract Introduction Study of the variations of bone characteristics with age in different animal models is important to design musculoskeletal studies. Thus, this study aimed to evaluate the bone mass, dimensions, and biomechanical parameters of the femur in young, middle-aged, and aged Wistar rats. Materials and Methods Thirty male rats (Rattus norvegicus) were divided in three groups (n = 10 per group)—3-month-old young rats, 12-month-old middle-aged rats, and 18-months-old aged rats. The right femurs were subjected sequentially to morphometric study (bone weight, cortical thickness) and biomechanical tests (maximum resistance strength and bone stiffness). Results We observed a significant increase in femur histological (cortical thickness) and biomechanical (maximum strength and bone stiffness) parameters with aging when compared with young animals. Conclusions With the advancing age, the right femoral bone of middle-aged and old animals had greater variations when compared with young animals. However, further studies with the aid of a comparison between right and left femur and other long bones in both male and female rats are needed to corroborate with our findings.

A Reduction in Behavioral Pattern Separation Is Attenuated by Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend in Middle-Aged Rats

2021 ◽  
Author(s):  
Erin K. Crowley ◽  
Stefanie Grabrucker ◽  
Caitriona M. Long-Smith ◽  
Alice Stack ◽  
Denise M. O'Gorman ◽  
...  
Keyword(s):  
Dietary Supplementation ◽  
Behavioral Pattern ◽  
Pattern Separation ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Sex-Specific Effects of Cardiovascular Risk Factors on Endothelium-Dependent Dilation and Endothelin Activity in Middle-Aged Women and Men

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0121810 ◽  
Author(s):  
Vijaywant Brar ◽  
Sartaj Gill ◽  
Carmine Cardillo ◽  
Manfredi Tesauro ◽  
Julio A. Panza ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Middle Aged ◽  
Specific Effects

scholarly journals Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

Hippocampus ◽  
2008 ◽  
Vol 18 (11) ◽  
pp. 1085-1088 ◽  
Author(s):  
Alexis M. Stranahan ◽  
Eric D. Norman ◽  
Kim Lee ◽  
Roy G. Cutler ◽  
Richard S. Telljohann ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Synaptic Plasticity ◽  
Aged Rats ◽  
Middle Aged ◽  
Hippocampal Synaptic Plasticity
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