Protective Effects of Exercise Training Against Aged Induced the Reduction of Cardiac Angiogenic Capacity in Middle Aged Rats

2020 ◽  
Vol 04 (01) ◽  
Author(s):  
Titiporn Mekrungruangwong ◽  
Pimpetch Kasetsuwan ◽  
Sheepsumon Viboolvorakul ◽  
Suthiluk Patumraj
Keyword(s):  
Exercise Training ◽  
Protective Effects ◽  
Aged Rats ◽  
Middle Aged

Muscle microvascular adaptation and angiogenic gene induction in response to exercise training are attenuated in middle-aged rats

2015 ◽  
Vol 11 (1) ◽  
pp. 23-33
Author(s):  
J. Suzuki
Keyword(s):  
Exercise Training ◽  
Acute Exercise ◽  
Young Group ◽  
Treadmill Running ◽  
Mrna Levels ◽  
Aged Rats ◽  
Middle Aged ◽  
Vegf Mrna ◽  
Aged Group ◽  
Exercise Induced

This study was designed to investigate exercise-induced changes in muscle capillarisation, the mRNA expression of angiogenic genes, and microRNA levels in young and middle-aged rats. Rats in the training groups were subjected to treadmill running 5 days a week for 3 weeks. The exercise protocol for the young (12-week old) group was 20-25 m/min, 40-60 min/day with a gradient of 15%, and for the middle-aged (12-month old) group was 18-20 m/min, 40-60 min/day with a gradient of 5%. The enzyme histochemical identification of capillary profiles was performed on cross-sections of gastrocnemius muscle. Total RNA was isolated, reverse transcription was performed, and mRNA and microRNA levels were determined by real-time PCR. The capillary-to-fibre ratio was significantly increased by exercise training in the young group (by 10%), but only slightly in the middle-aged (by 5%) group. Vascular endothecial growth factor (VEGF) mRNA levels were at significantly higher values after acute exercise (1.6-fold) and the 3-week training protocol (1.9-fold) in the young group, but not in the middle-aged group. VEGF protein expression levels were significantly increased after training in the young group only. Endothelial nitric oxide synthase, VEGF-R2 and thrombospondin-1 mRNA levels were significantly lower in the middle-aged group than in the young group. Anti-angiogenic miR-195 levels were significantly enhanced by exercise training in the middle-aged group only. These results indicated that the exercise-induced adaptation of muscle capillarity was attenuated in middle-aged rats, possibly by the lower induction of VEGF and up-regulation of anti-angiogenic miRNA expression.

The protective effects of melatonin from oxidative damage induced by amyloid beta-peptide 25-35 in middle-aged rats

2002 ◽  
Vol 32 (2) ◽  
pp. 85-89 ◽  
Author(s):  
Y. X. Shen ◽  
S. Y. Xu ◽  
W. Wei ◽  
X. X. Sun ◽  
L. H. Liu ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Amyloid Beta ◽  
Amyloid Beta Peptide ◽  
Protective Effects ◽  
Aged Rats ◽  
Middle Aged ◽  
Beta Peptide

Effect of aging and exercise on GLUT-4 glucose transporters in muscle

1992 ◽  
Vol 263 (2) ◽  
pp. E362-E367 ◽  
Author(s):  
M. Kern ◽  
P. L. Dolan ◽  
R. S. Mazzeo ◽  
J. A. Wells ◽  
G. L. Dohm
Keyword(s):  
Exercise Training ◽  
Glucose Transporter ◽  
Treadmill Running ◽  
Aged Rats ◽  
Middle Aged ◽  
Protein Levels ◽  
Fischer 344 ◽  
Glut 4 ◽  
Significant Difference ◽  
Muscle Types

This study was conducted to investigate whether changes in muscle glucose transporter GLUT-4 protein might be associated with a previously reported deterioration in glucose tolerance with aging, and, furthermore, to determine whether exercise training could increase GLUT-4 protein levels in older animals. GLUT-4 protein concentration was measured in soleus, gastrocnemius, and extensor digitorum longus muscles of trained (10 or 15 wk treadmill running) and untrained young (6-8 mo), middle-aged (15-17 mo), and old (27-29 mo) Fischer 344 rats. All GLUT-4 protein values were expressed as a percent of the mean for the young untrained group. Two-way analysis of variance demonstrated significant main effects of both training and aging in the gastrocnemius and soleus muscles. Exercise training produced significant increases in GLUT-4 protein in the soleus muscle of young (273 +/- 32.9 vs. 100 +/- 38.5%) and middle-aged rats (215 +/- 19.9 vs. 108 +/- 33.2%) compared with sedentary controls. Similar significant increases were also found in the gastrocnemius muscle of young (169 +/- 20.1 vs. 100 +/- 5.8%) and middle-aged rats (167 +/- 46.7 vs. 60 +/- 7.9%) with training. In the oldest rats, GLUT-4 was not significantly increased with training, but the trend toward an increase was apparent in all three muscle types. The main effect of aging was primarily due to a statistically significant difference between the old trained and young trained rats. A trend toward decreased GLUT-4 with aging was apparent in the untrained animals, but this was not statistically significant.

Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats

2016 ◽  
Vol 7 (6) ◽  
pp. 2624-2634 ◽  
Author(s):  
Shuangchan Wu ◽  
Yuan Yue ◽  
Anlin Peng ◽  
Lu Zhang ◽  
Jin Xiang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Injury ◽  
Neurological Deficits ◽  
Experimental Stroke ◽  
Protective Effects ◽  
Aged Rats ◽  
Middle Aged ◽  
Nrf2 Activation ◽  
Underlying Mechanisms

The aim of our study was to investigate the protective effects and underlying mechanisms of myricetin, a bioactive food compound, on brain injury and neurological deficits after ischemic stroke.

Protective effects of chronic treatment with a standardized extract of Ginkgo biloba L. in the prefrontal cortex and dorsal hippocampus of middle-aged rats

2016 ◽  
Vol 313 ◽  
pp. 144-150 ◽  
Author(s):  
Marcelo L. Ribeiro ◽  
Luciana M. Moreira ◽  
Demetrius P. Arçari ◽  
Letícia França dos Santos ◽  
Antônio Cezar Marques ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Ginkgo Biloba ◽  
Chronic Treatment ◽  
Dorsal Hippocampus ◽  
Protective Effects ◽  
Aged Rats ◽  
Middle Aged

Protective Effects of 17β-Estradiol on Hippocampal Myelinated Fibers in Ovariectomized Middle-aged Rats

Neuroscience ◽  
2018 ◽  
Vol 385 ◽  
pp. 143-153 ◽  
Author(s):  
Qian Xiao ◽  
Yanmin Luo ◽  
Fulin Lv ◽  
Qi He ◽  
Hong Wu ◽  
...  
Keyword(s):  
Protective Effects ◽  
Aged Rats ◽  
Middle Aged ◽  
Myelinated Fibers ◽  
17Β Estradiol

Exercise training causes a partial improvement through increasing testosterone and eNOS for erectile function in middle-aged rats

2018 ◽  
Vol 108 ◽  
pp. 131-138 ◽  
Author(s):  
Dae Yun Seo ◽  
Sung Ryul Lee ◽  
Hyo Bum Kwak ◽  
Hyuntea Park ◽  
Kyo Won Seo ◽  
...  
Keyword(s):  
Exercise Training ◽  
Erectile Function ◽  
Aged Rats ◽  
Middle Aged
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