A Reduction in Behavioral Pattern Separation Is Attenuated by Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend in Middle-Aged Rats

2021 ◽  
Author(s):  
Erin K. Crowley ◽  
Stefanie Grabrucker ◽  
Caitriona M. Long-Smith ◽  
Alice Stack ◽  
Denise M. O'Gorman ◽  
...  
Keyword(s):  
Dietary Supplementation ◽  
Behavioral Pattern ◽  
Pattern Separation ◽  
Aged Rats ◽  
Middle Aged

Protective Effects of Exercise Training Against Aged Induced the Reduction of Cardiac Angiogenic Capacity in Middle Aged Rats

2020 ◽  
Vol 04 (01) ◽  
Author(s):  
Titiporn Mekrungruangwong ◽  
Pimpetch Kasetsuwan ◽  
Sheepsumon Viboolvorakul ◽  
Suthiluk Patumraj
Keyword(s):  
Exercise Training ◽  
Protective Effects ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Effects of Food Restriction on Mechanical Properties of Arterial System in Adult and Middle-Aged Rats

1999 ◽  
Vol 54 (10) ◽  
pp. B441-B447 ◽  
Author(s):  
K.-C. Chang ◽  
C.-Y. Chow ◽  
Y.-I. Peng ◽  
T.-J. Chen ◽  
Y.-F. Tsai
Keyword(s):  
Mechanical Properties ◽  
Food Restriction ◽  
Arterial System ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Age-Related Effects on Right Femoral Bone of Male Wistar Rats: A Morphometric and Biomechanical Study

2021 ◽  
Author(s):  
Sheila Martins Puelker ◽  
Sonia Regina Ribeiro de Castro ◽  
Romeu Rodrigues de Souza ◽  
Laura Beatriz Mesiano Maifrino ◽  
Ricardo Aparecido Baptista Nucci ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Wistar Rats ◽  
Female Rats ◽  
Male Rats ◽  
Aged Rats ◽  
Femoral Bone ◽  
Middle Aged ◽  
Left Femur ◽  
Bone Stiffness ◽  
The Right

Abstract Introduction Study of the variations of bone characteristics with age in different animal models is important to design musculoskeletal studies. Thus, this study aimed to evaluate the bone mass, dimensions, and biomechanical parameters of the femur in young, middle-aged, and aged Wistar rats. Materials and Methods Thirty male rats (Rattus norvegicus) were divided in three groups (n = 10 per group)—3-month-old young rats, 12-month-old middle-aged rats, and 18-months-old aged rats. The right femurs were subjected sequentially to morphometric study (bone weight, cortical thickness) and biomechanical tests (maximum resistance strength and bone stiffness). Results We observed a significant increase in femur histological (cortical thickness) and biomechanical (maximum strength and bone stiffness) parameters with aging when compared with young animals. Conclusions With the advancing age, the right femoral bone of middle-aged and old animals had greater variations when compared with young animals. However, further studies with the aid of a comparison between right and left femur and other long bones in both male and female rats are needed to corroborate with our findings.

scholarly journals Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

Hippocampus ◽  
2008 ◽  
Vol 18 (11) ◽  
pp. 1085-1088 ◽  
Author(s):  
Alexis M. Stranahan ◽  
Eric D. Norman ◽  
Kim Lee ◽  
Roy G. Cutler ◽  
Richard S. Telljohann ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Synaptic Plasticity ◽  
Aged Rats ◽  
Middle Aged ◽  
Hippocampal Synaptic Plasticity

Late-onset caloric restriction alters skeletal muscle metabolism by modulating pyruvate metabolism

2015 ◽  
Vol 308 (11) ◽  
pp. E942-E949 ◽  
Author(s):  
Chiao-nan (Joyce) Chen ◽  
Shang-Ying Lin ◽  
Yi-Hung Liao ◽  
Zhen-jie Li ◽  
Alice May-Kuen Wong
Keyword(s):  
Energy Metabolism ◽  
Muscle Mass ◽  
Mitochondrial Biogenesis ◽  
Muscle Metabolism ◽  
Muscle Loss ◽  
Aged Rats ◽  
Middle Aged ◽  
Pyruvate Metabolism ◽  
Age Related ◽  
Age Dependent

Caloric restriction (CR) attenuates age-related muscle loss. However, the underlying mechanism responsible for this attenuation is not fully understood. This study evaluated the role of energy metabolism in the CR-induced attenuation of muscle loss. The aims of this study were twofold: 1) to evaluate the effect of CR on energy metabolism and determine its relationship with muscle mass, and 2) to determine whether the effects of CR are age dependent. Young and middle-aged rats were randomized into either 40% CR or ad libitum (AL) diet groups for 14 wk. Major energy-producing pathways in muscles, i.e., glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), were examined. We found that the effects of CR were age dependent. CR improved muscle metabolism and normalized muscle mass in middle-aged animals but not young animals. CR decreased glycolysis and increased the cellular dependency for OXPHOS vs. glycolysis in muscles of middle-aged rats, which was associated with the improvement of normalized muscle mass. The metabolic reprogramming induced by CR was related to modulation of pyruvate metabolism and increased mitochondrial biogenesis. Compared with animals fed AL, middle-aged animals with CR had lower lactate dehydrogenase A content and greater mitochondrial pyruvate carrier content. Markers of mitochondrial biogenesis, including AMPK activation levels and SIRT1 and COX-IV content, also showed increased levels. In conclusion, 14 wk of CR improved muscle metabolism and preserved muscle mass in middle-aged animals but not in young developing animals. CR-attenuated age-related muscle loss is associated with reprogramming of the metabolic pathway from glycolysis to OXPHOS.

Abstract 067: Long-Term Ivabradine Treatment Does Not Preserve Myocardial Perfusion and Coronary Reserve in Middle-Aged Rats with Large Myocardial Infarction

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Eduard I Dedkov ◽  
Yevgen Bogatyryov ◽  
Daniela McCooey ◽  
Lance P Christensen ◽  
Robert J Tomanek
Keyword(s):  
Myocardial Perfusion ◽  
Left Ventricular ◽  
Coronary Artery Ligation ◽  
Coronary Perfusion ◽  
Free Wall ◽  
Aged Rats ◽  
Middle Aged ◽  
Perfusion Reserve ◽  
Coronary Conductance

Background: We have previously shown that 1-month treatment with ivabradine (IVA), the selective cardiac pacemaker I f current inhibitor, preserved myocardial perfusion and coronary perfusion reserve in post-MI middle-aged rats. However, the persistence of this cardioprotective effect after a prolonged period of IVA treatment remains to be determined. Methods: Acute MI was induced in 12-month-old male Sprague-Dawley rats by left coronary artery ligation. Twenty four hours later, the rats with a confirmed large transmural MI (>50% of the left ventricular (LV) free wall) were randomly assigned in two experimental groups. In a first group, rats were treated with IVA i.p. via osmotic pumps in a dose of 10.5 mg/kg/day for 3 months (MI+IVA). In a second group, rats received placebo treatment (5% dextrose) during the same time period (MI). Sham-operated rats served as an age-matched control. At the end of experimental period, myocardial perfusion (baseline and maximal coronary conductance per 100g of tissue) and coronary perfusion reserve (fold increase between baseline and maximal coronary conductance) were determined in non-infarcted LV free wall and interventricular septum by using the neutron-activated stable isotope-labeled microsphere technique. Results: During 3 months of IVA treatment, heart rate in MI+IVA rats was consistently reduced compared to untreated MI rats by mean of 30.6%. Nevertheless, we found that the infarct size and the extent of LV remodeling were relatively comparable between MI and MI+IVA rats three months after surgery. Moreover, the levels of baseline and maximal coronary conductance were similar in LV free wall and septum between two experimental groups. Consequently, IVA-treated rats revealed no difference in coronary perfusion reserve as compared to untreated post-MI animals (2.22±0.46 vs. 2.59±0.41 in LV free wall and 2.30±0.59 vs. 2.68±0.44 in septum, respectively). However, the rats of both post-MI groups had markedly reduced levels of maximal coronary blood flow as compared to non-infarcted controls (p≤0.01). Conclusion: Our data demonstrate that long-term IVA treatment does not provide sustainable improvement in LV myocardial perfusion and coronary perfusion reserve in middle-aged rats following large MI.

Chlorpyrifos with age-dependent effects in cardiac tissue of male rats

2021 ◽  
Vol 14 ◽  
Author(s):  
Behzad Mesbahzadeh ◽  
Hossein Salarjavan ◽  
Saeed Samarghandian ◽  
Tahereh Farkhondeh
Keyword(s):  
Cardiac Tissue ◽  
Organophosphorus Pesticides ◽  
Male Rats ◽  
Aged Rats ◽  
Middle Aged ◽  
Sod Activity ◽  
Age Dependent ◽  
Oxidative Modifications ◽  
Total Antioxidant ◽  
Male Wistar Rats

: Age-dependent toxic effects of organophosphorus pesticides (OPs) have not fully understood. Current study aimed to investigate the cardiotoxic damage of chlorpyrifos (CPF) by evaluating oxidative modifications in young (2-month old), middle-aged (10-month old), and aged (20-month old) rats. Five mg/kg of CPF was administered orally for 45 days to young, middle-aged, and aged male Wistar rats. At the end, animals were anesthetized and the heart of each rat was dissected for biochemical assay. Malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were assessed in the cardiac tissue of rats. The results indicated an increase in the levels of MDA and NO, and also a decline in the levels of GSH and TAC as well as a decrease in the SOD activity in the heart of aged rats compared with young rats. CPF administration deteriorated these changes in the heart of exposed rats compared with the age-matched controls. Additionally, these oxidative modifications were more severe in aged rats versus other age. In conclusion, advancing age may increase oxidative changes in the heart of animals exposed to CPF. It is suggested that aging can affect cardiac toxicity induced by OPs.

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