Association between low levels of plasma protein S and recurrent pregnancy loss or perinatal complications

2016 ◽  
Vol 118 ◽  
pp. 143
Author(s):  
Masashi Deguchi ◽  
Nanae Shinozaki ◽  
Yasuhiko Ebina ◽  
Hideto Yamada
Keyword(s):  
Plasma Protein ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Protein S ◽  
Perinatal Complications ◽  
Low Levels

scholarly journals Frequency of Thrombophilic Gene Mutations in Patients with Deep Vein Thrombosis and in Women with Recurrent Pregnancy Loss

2017 ◽  
Vol 12 (1) ◽  
pp. 162-166 ◽  
Author(s):  
Mahmoud Mohamed Elgari ◽  
Nadir Ahmed Ibrahim ◽  
Abdel Rahim Mahmoud Muddathir ◽  
Faris Mergheni Eltoom ◽  
Ibrahim M Ibrahim
Keyword(s):  
Deep Vein Thrombosis ◽  
Protein C ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Factor V Leiden ◽  
Protein S ◽  
Prothrombin G20210a ◽  
Factor V ◽  
Vein Thrombosis ◽  
Deep Vein

AbstractThrombophilia may be anticipated by single or combined hereditary defects in encoding genes factor V, Prothrombin, and MTHFR. The aim of this study was to determine the prevalence and associated risks of V Leiden (G1691A), Prothrombin (G20210A), and MTHFR (C677T) mutations in Saudi women with Deep Vein Thrombosis (DVT) and women with recurrent pregnancy loss (RPL). Protein C and protein S activity were measured to determine combined effects, if any. We examined 60 women with a history of DVT and 60 with RPL, extracted DNA from EDTA blood and determined three mutations by using multiplex PCR reactions followed by Strip Assay KIT. Pro C Global assay was used to determine the cutoff value [PCATNR = 0.80]. Protein C/S chromogenic assay was used to estimate protein C and S percentages. Frequency of Factor V Leiden G/A genotype in patients with DVT 7 (11.6%) had a significant association for DVT χ2 (OR = 5.1, P = 0.03). In women with RPL the three mutations did not show any significant association, levels of Protein C, protein S and PCAT-NR in patient groups not different from controls (P > 0.05). In conclusion, we recommend expanding on these data to provide larger-scale studies.

Pregnancy-associated plasma protein-A polymorphism and the risk of recurrent pregnancy loss

2006 ◽  
Vol 70 (1-2) ◽  
pp. 99-108 ◽  
Author(s):  
Kana Suzuki ◽  
Fumihiro Sata ◽  
Hideto Yamada ◽  
Yasuaki Saijo ◽  
Noriko Tsuruga ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Protein A

Low levels of plasma protein S, protein C and coagulation factor XII during early pregnancy and adverse pregnancy outcome

2015 ◽  
Vol 114 (07) ◽  
pp. 65-69 ◽  
Author(s):  
Yasuhiko Ebina ◽  
Masahiro Ieko ◽  
Sumiyoshi Naito ◽  
Gen Kobashi ◽  
Masashi Deguchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasma Protein ◽  
Early Pregnancy ◽  
Protein C ◽  
Coagulation Factor ◽  
Protein S ◽  
Factor Xii ◽  
Independent Risk Factors ◽  
Low Levels ◽  
Adverse Pregnancy

SummaryIt was the study objective to evaluate whether low levels of plasma protein S (PS) activity, free PS, protein C (PC) activity and coagulation factor XII (FXII) during early pregnancy are related to adverse pregnancy outcomes. Peripheral blood samples were obtained at 8–14 gestational weeks (GW) from a consecutive series of 1,220 women. The levels of plasma PS activity, free PS, PC activity, and FXII were measured. Cut-off values were defined as < 1st, < 5th, and < 10th percentiles of values obtained from 933 women whose pregnancies ended in normal deliveries without complications. PS activity of < 10th percentile yielded risks of pregnancy-induced hypertension (PIH) and severe PIH, while free PS level of < 5th percentile yielded a risk of preeclampsia. FXII level of < 1st percentile yielded a risk of premature delivery (PD) at < 34 GW. None was associated with PD at < 37 GW, fetal growth restriction or fetal loss. A multivariate analysis demonstrated that PS activity of < 10th percentile (odds ratio 5.9, 95 % confidence interval 1.7–18.1) and body mass index (BMI) ≥ 25 kg/m2 (4.3, 1.1–13.3) were independent risk factors for severe PIH. Similarly, free PS level of < 5th percentile (4.4, 1.0–14.3) and BMI ≥ 25 kg/m2 (4.0, 1.3–10.9) were independent risk factors for pre-eclampsia. In conclusion, women with low levels of plasma PS activity and free PS during early pregnancy might have increased risks of PIH, severe PIH or pre-eclampsia. Women with low FXII level might have an increased risk of PD at < 34 GW.

scholarly journals Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss

2015 ◽  
Vol 112 ◽  
pp. 137
Author(s):  
Nanae Shinozaki ◽  
Yasuhiko Ebina ◽  
Masashi Deguchi ◽  
Kenji Tanimura ◽  
Mayumi Morizane ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Protein S ◽  
Protein S Deficiency ◽  
S Deficiency ◽  
Complicated Pregnancy

Low levels of plasma protein S as a risk factor for adverse pregnancy outcome

2018 ◽  
Vol 130 ◽  
pp. 45
Author(s):  
Masashi Deguchi ◽  
Kenji Tanimura ◽  
Yasuhiko Ebina ◽  
Hideto Yamada
Keyword(s):  
Risk Factor ◽  
Pregnancy Outcome ◽  
Plasma Protein ◽  
Adverse Pregnancy Outcome ◽  
Protein S ◽  
Low Levels ◽  
Adverse Pregnancy
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