Low levels of plasma protein S as a risk factor for adverse pregnancy outcome

2018 ◽  
Vol 130 ◽  
pp. 45
Author(s):  
Masashi Deguchi ◽  
Kenji Tanimura ◽  
Yasuhiko Ebina ◽  
Hideto Yamada
Keyword(s):  
Risk Factor ◽  
Pregnancy Outcome ◽  
Plasma Protein ◽  
Adverse Pregnancy Outcome ◽  
Protein S ◽  
Low Levels ◽  
Adverse Pregnancy

O127. Low levels of plasma protein S, protein C and coagulation factor XII during early pregnancy and adverse pregnancy outcome

2015 ◽  
Vol 5 (3) ◽  
pp. 239-240
Author(s):  
Yasuhiko Ebina ◽  
Masahiro Ieko ◽  
Sumiyoshi Naito ◽  
Gen Kobashi ◽  
Masashi Deguchi ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Plasma Protein ◽  
Early Pregnancy ◽  
Protein C ◽  
Adverse Pregnancy Outcome ◽  
Coagulation Factor ◽  
Protein S ◽  
Factor Xii ◽  
Low Levels ◽  
Adverse Pregnancy

scholarly journals Adverse pregnancy outcome in patients with low pregnancy-associated plasma protein-A: The Indian Experience

2015 ◽  
Vol 41 (7) ◽  
pp. 1003-1008 ◽  
Author(s):  
Sangeeta Gupta ◽  
Manisha Goyal ◽  
Deepti Verma ◽  
Anjana Sharma ◽  
Namita Bharadwaj ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Plasma Protein ◽  
Adverse Pregnancy Outcome ◽  
Protein A ◽  
Indian Experience ◽  
Adverse Pregnancy

597: Maternal serum low PAPP-A in the first trimester is an independent risk factor for adverse pregnancy outcome

2008 ◽  
Vol 199 (6) ◽  
pp. S172
Author(s):  
Markku Ryynanen ◽  
Sini Peuhkurinen ◽  
Mika Gissler ◽  
Jaana Marttala ◽  
Jaakko Ignatius ◽  
...  
Keyword(s):  
Risk Factor ◽  
Pregnancy Outcome ◽  
Independent Risk Factor ◽  
Adverse Pregnancy Outcome ◽  
First Trimester ◽  
Maternal Serum ◽  
Adverse Pregnancy

scholarly journals Addison’s Disease in Women Is a Risk Factor for an Adverse Pregnancy Outcome

2010 ◽  
Vol 95 (12) ◽  
pp. 5249-5257 ◽  
Author(s):  
Sigridur Björnsdottir ◽  
Sven Cnattingius ◽  
Lena Brandt ◽  
Anna Nordenström ◽  
Anders Ekbom ◽  
...  
Keyword(s):  
Risk Factor ◽  
Pregnancy Outcome ◽  
Adverse Pregnancy Outcome ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Adverse Pregnancy

Low levels of plasma protein S, protein C and coagulation factor XII during early pregnancy and adverse pregnancy outcome

2015 ◽  
Vol 114 (07) ◽  
pp. 65-69 ◽  
Author(s):  
Yasuhiko Ebina ◽  
Masahiro Ieko ◽  
Sumiyoshi Naito ◽  
Gen Kobashi ◽  
Masashi Deguchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasma Protein ◽  
Early Pregnancy ◽  
Protein C ◽  
Coagulation Factor ◽  
Protein S ◽  
Factor Xii ◽  
Independent Risk Factors ◽  
Low Levels ◽  
Adverse Pregnancy

SummaryIt was the study objective to evaluate whether low levels of plasma protein S (PS) activity, free PS, protein C (PC) activity and coagulation factor XII (FXII) during early pregnancy are related to adverse pregnancy outcomes. Peripheral blood samples were obtained at 8–14 gestational weeks (GW) from a consecutive series of 1,220 women. The levels of plasma PS activity, free PS, PC activity, and FXII were measured. Cut-off values were defined as < 1st, < 5th, and < 10th percentiles of values obtained from 933 women whose pregnancies ended in normal deliveries without complications. PS activity of < 10th percentile yielded risks of pregnancy-induced hypertension (PIH) and severe PIH, while free PS level of < 5th percentile yielded a risk of preeclampsia. FXII level of < 1st percentile yielded a risk of premature delivery (PD) at < 34 GW. None was associated with PD at < 37 GW, fetal growth restriction or fetal loss. A multivariate analysis demonstrated that PS activity of < 10th percentile (odds ratio 5.9, 95 % confidence interval 1.7–18.1) and body mass index (BMI) ≥ 25 kg/m2 (4.3, 1.1–13.3) were independent risk factors for severe PIH. Similarly, free PS level of < 5th percentile (4.4, 1.0–14.3) and BMI ≥ 25 kg/m2 (4.0, 1.3–10.9) were independent risk factors for pre-eclampsia. In conclusion, women with low levels of plasma PS activity and free PS during early pregnancy might have increased risks of PIH, severe PIH or pre-eclampsia. Women with low FXII level might have an increased risk of PD at < 34 GW.

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