A novel hypothesis on pathogenesis of autoantibodies to kininogens, factor XII and protein S in patients with recurrent pregnancy loss

2016 ◽  
Vol 118 ◽  
pp. 143
Author(s):  
Toshitaka Sugi
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Protein S ◽  
Factor Xii

scholarly journals Frequency of Thrombophilic Gene Mutations in Patients with Deep Vein Thrombosis and in Women with Recurrent Pregnancy Loss

2017 ◽  
Vol 12 (1) ◽  
pp. 162-166 ◽  
Author(s):  
Mahmoud Mohamed Elgari ◽  
Nadir Ahmed Ibrahim ◽  
Abdel Rahim Mahmoud Muddathir ◽  
Faris Mergheni Eltoom ◽  
Ibrahim M Ibrahim
Keyword(s):  
Deep Vein Thrombosis ◽  
Protein C ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Factor V Leiden ◽  
Protein S ◽  
Prothrombin G20210a ◽  
Factor V ◽  
Vein Thrombosis ◽  
Deep Vein

AbstractThrombophilia may be anticipated by single or combined hereditary defects in encoding genes factor V, Prothrombin, and MTHFR. The aim of this study was to determine the prevalence and associated risks of V Leiden (G1691A), Prothrombin (G20210A), and MTHFR (C677T) mutations in Saudi women with Deep Vein Thrombosis (DVT) and women with recurrent pregnancy loss (RPL). Protein C and protein S activity were measured to determine combined effects, if any. We examined 60 women with a history of DVT and 60 with RPL, extracted DNA from EDTA blood and determined three mutations by using multiplex PCR reactions followed by Strip Assay KIT. Pro C Global assay was used to determine the cutoff value [PCATNR = 0.80]. Protein C/S chromogenic assay was used to estimate protein C and S percentages. Frequency of Factor V Leiden G/A genotype in patients with DVT 7 (11.6%) had a significant association for DVT χ2 (OR = 5.1, P = 0.03). In women with RPL the three mutations did not show any significant association, levels of Protein C, protein S and PCAT-NR in patient groups not different from controls (P > 0.05). In conclusion, we recommend expanding on these data to provide larger-scale studies.

The antigenic binding sites of autoantibodies to factor XII in patients with recurrent pregnancy losses

2008 ◽  
Vol 99 (02) ◽  
pp. 316-323 ◽  
Author(s):  
Yoshimi Fujita ◽  
Hidehiko Matsubayashi ◽  
Shun-ichiro Izumi ◽  
Mikio Mikami ◽  
Akifumi Inomo ◽  
...  
Keyword(s):  
Binding Site ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Platelet Glycoprotein ◽  
Factor Xii ◽  
Binding Studies ◽  
Amino Terminal ◽  
Recurrent Pregnancy Losses ◽  
Direct Binding ◽  
Positive Recurrent

SummaryRecently, numerous studies have suggested an association between factor XII (FXII) deficiency and recurrent pregnancy losses, and between autoantibodies to FXII and recurrent pregnancy losses. Autoantibodies to FXII rather than FXII deficiency may be a risk factor for recurrent pregnancy losses. To know the pathogenesis of autoantibodies to FXII, epitope mapping study was done. Seventeen anti-FXII antibody positive recurrent pregnancy loss patients were chosen for this study. We used synthetic peptides in inhibition and direct binding studies to identify the antigenic binding site of autoantibodies to FXII. Among plasmas from 17 recurrent pregnancy loss patients who were positive for autoantibodies to FXII, 13 patients (76.5%) recognized amino acids 1–30, the amino-terminal heavy chain region that is known as factor XII binding site to platelet glycoprotein Ibα.

scholarly journals Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss

2015 ◽  
Vol 112 ◽  
pp. 137
Author(s):  
Nanae Shinozaki ◽  
Yasuhiko Ebina ◽  
Masashi Deguchi ◽  
Kenji Tanimura ◽  
Mayumi Morizane ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Protein S ◽  
Protein S Deficiency ◽  
S Deficiency ◽  
Complicated Pregnancy
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