Epitope mapping of autoantibodies to protein S in patients with recurrent pregnancy loss

2015 ◽  
Vol 112 ◽  
pp. 130
Author(s):  
Toshitaka Sugi ◽  
Yoshihiro Sato ◽  
Rie Sakai
Keyword(s):  
Pregnancy Loss ◽  
Epitope Mapping ◽  
Recurrent Pregnancy Loss ◽  
Protein S

scholarly journals Frequency of Thrombophilic Gene Mutations in Patients with Deep Vein Thrombosis and in Women with Recurrent Pregnancy Loss

2017 ◽  
Vol 12 (1) ◽  
pp. 162-166 ◽  
Author(s):  
Mahmoud Mohamed Elgari ◽  
Nadir Ahmed Ibrahim ◽  
Abdel Rahim Mahmoud Muddathir ◽  
Faris Mergheni Eltoom ◽  
Ibrahim M Ibrahim
Keyword(s):  
Deep Vein Thrombosis ◽  
Protein C ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Factor V Leiden ◽  
Protein S ◽  
Prothrombin G20210a ◽  
Factor V ◽  
Vein Thrombosis ◽  
Deep Vein

AbstractThrombophilia may be anticipated by single or combined hereditary defects in encoding genes factor V, Prothrombin, and MTHFR. The aim of this study was to determine the prevalence and associated risks of V Leiden (G1691A), Prothrombin (G20210A), and MTHFR (C677T) mutations in Saudi women with Deep Vein Thrombosis (DVT) and women with recurrent pregnancy loss (RPL). Protein C and protein S activity were measured to determine combined effects, if any. We examined 60 women with a history of DVT and 60 with RPL, extracted DNA from EDTA blood and determined three mutations by using multiplex PCR reactions followed by Strip Assay KIT. Pro C Global assay was used to determine the cutoff value [PCATNR = 0.80]. Protein C/S chromogenic assay was used to estimate protein C and S percentages. Frequency of Factor V Leiden G/A genotype in patients with DVT 7 (11.6%) had a significant association for DVT χ2 (OR = 5.1, P = 0.03). In women with RPL the three mutations did not show any significant association, levels of Protein C, protein S and PCAT-NR in patient groups not different from controls (P > 0.05). In conclusion, we recommend expanding on these data to provide larger-scale studies.

scholarly journals Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss

2015 ◽  
Vol 112 ◽  
pp. 137
Author(s):  
Nanae Shinozaki ◽  
Yasuhiko Ebina ◽  
Masashi Deguchi ◽  
Kenji Tanimura ◽  
Mayumi Morizane ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Protein S ◽  
Protein S Deficiency ◽  
S Deficiency ◽  
Complicated Pregnancy

scholarly journals Incidence of thrombophilia in patients with recurrent pregnancy loss

2020 ◽  
Vol 9 (3) ◽  
pp. 1007
Author(s):  
Ganesh Bharaswadkar
Keyword(s):  
Protein C ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Protein S ◽  
Anticardiolipin Antibodies ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Inherited Thrombophilia ◽  
S Deficiency ◽  
Recurrent Pregnancy Losses

Background: Approximately 1-3% of women of reproductive age suffer from recurrent pregnancy loss. Objective of this study was to evaluate the association between recurrent pregnancy loss and thrombophilia.Methods: This is a descriptive study, involving retrospective analysis of patients with recurrent pregnancy losses. Patients with recurrent pregnancy loss in whom associated morbidity factors were excluded underwent screening for both acquired and inherited thrombophilia.Results: A total of 20 patients were screened for acquired and inherited thrombophilia with recurrent pregnancy loss. Thrombophilia was diagnosed in 70% cases. Out of which, anticardiolipin antibodies was found positive in 57% of patients, protein C 7% and protein S deficiency was observed in 35% cases.Conclusions: Thrombophilias are associated with recurrent pregnancy loss. Patients in whom other associated morbid factors are excluded, should be offered screening for thrombophilia. Multidisciplinary management involving hematologist is vital for management.

scholarly journals Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss

2016 ◽  
Vol 32 (8) ◽  
pp. 672-674 ◽  
Author(s):  
Nanae Shinozaki ◽  
Yasuhiko Ebina ◽  
Masashi Deguchi ◽  
Kenji Tanimura ◽  
Mayumi Morizane ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Protein S ◽  
Protein S Deficiency ◽  
S Deficiency ◽  
Complicated Pregnancy
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