Characteristic distributions of regional cerebral blood flow changes in major depressive disorder patients: A pseudo-continuous arterial spin labeling (pCASL) study

2014 ◽  
Vol 165 ◽  
pp. 59-63 ◽  
Author(s):  
Miho Ota ◽  
Takamasa Noda ◽  
Noriko Sato ◽  
Kotaro Hattori ◽  
Toshiya Teraishi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Major Depressive Disorder ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Regional Cerebral Blood Flow ◽  
Spin Labeling ◽  
Regional Cerebral Blood ◽  
Major Depressive ◽  
Flow Changes ◽  
Continuous Arterial Spin Labeling

scholarly journals Quantitative Changes in Regional Cerebral Blood Flow Induced by Cold, Heat and Ischemic Pain

2012 ◽  
Vol 117 (4) ◽  
pp. 857-867 ◽  
Author(s):  
Michael A. Frölich ◽  
Hrishikesh Deshpande ◽  
Timothy Ness ◽  
Georg Deutsch
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Regional Cerebral Blood Flow ◽  
Spin Labeling ◽  
Angular Gyrus ◽  
Ischemic Pain ◽  
Regional Cerebral Blood ◽  
Cold Pain ◽  
Area 6

Background The development of arterial spin labeling methods has allowed measuring regional cerebral blood flow (rCBF) quantitatively and to show the pattern of cerebral activity associated with any state such as a sustained pain state or changes due to a neurotropic drug. Methods The authors studied the differential effects of three pain conditions in 10 healthy subjects on a 3 Tesla scanner during resting baseline, heat, cold, and ischemic pain using continuous arterial spin labeling. Results Cold pain showed the greatest absolute rCBF increases in left anterior cingulate cortex, left amygdala, left angular gyrus, and Brodmann area 6, and a significant rCBF decrease in the cerebellum. Changes in rCBF were characteristic of the type of pain condition: cold and heat pain showed increases, whereas the ischemic condition showed a reduction in mean absolute gray matter flow compared with rest. An association of subjects' pain tolerance and cerebral blood flow was noted. Conclusions The observation that quantitative rCBF changes are characteristic of the pain task used and that there is a consistent rCBF change in Brodman area 6, an area responsible for the integration of a motor response to pain, should provide extremely useful information in the quest to develop an imaging biomarker of pain. Conceivably, response in BA6 may serve as an objective measure of analgesic efficacy.

scholarly journals Case Report: Changes in Regional Cerebral Blood Flow in Chronic Akathisia of a Depressed Patient Before and After Electroconvulsive Therapy Treatment

2021 ◽  
Vol 12 ◽  
Author(s):  
Akihito Suzuki ◽  
Ryota Kobayashi ◽  
Toshinori Shirata ◽  
Hitomi Komoriya ◽  
Masafumi Kanoto ◽  
...  
Keyword(s):  
Blood Flow ◽  
Major Depressive Disorder ◽  
Cerebral Blood Flow ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Regional Cerebral Blood Flow ◽  
Parietal Lobe ◽  
Regional Cerebral Blood ◽  
Major Depressive ◽  
Before And After

Akathisia, which characterized by subjective restlessness and objective hyperactivity, is induced mostly by antipsychotics and antidepressants. Chronic akathisia is defined as persistence of symptoms for more than 3 months. The pathophysiology of chronic akathisia remains unclear. This report describes a depressed patient, a 66-year-old woman with a diagnosis of major depressive disorder, with chronic akathisia. Her regional cerebral blood flow (rCBF) was measured using single photon emission computed tomography (SPECT) before and after the treatment with electroconvulsive therapy (ECT). She had experienced akathisia-like symptoms three times prior because of risperidone, escitalopram, and clomipramine administration, accompanied by major depression. After levomepromazine was added to quetiapine to treat insomnia, she developed akathisia symptoms such as a sense of restlessness and inability to sit in one place for a few minutes. These antipsychotics were withdrawn. Propranolol was administered, leading to no apparent improvement for 8 months. After she was diagnosed as having major depressive disorder and chronic akathisia, she received 10 sessions of bilateral ECT. Her depressive symptoms improved greatly. Akathisia disappeared completely after ECT. SPECT revealed that rCBF was decreased in the middle frontal gyrus and parietal lobe, that it was increased in the thalamus, fusiform gyrus, and cerebellum before ECT, and that these abnormalities in rCBF were approaching normal levels after ECT. Findings presented in this report suggest ECT as a beneficial treatment for chronic akathisia. Altered rCBF in the middle frontal gyrus, parietal lobe, thalamus, fusiform gyrus, and cerebellum, and especially decreased rCBF in the parietal lobe, may be related to the pathophysiology of chronic akathisia.

scholarly journals Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder

2012 ◽  
Vol 2 (1) ◽  
Author(s):  
Jonathan Savitz ◽  
Allison C. Nugent ◽  
Dara M. Cannon ◽  
Paul J. Carlson ◽  
Rebecca Davis ◽  
...  
Keyword(s):  
Blood Flow ◽  
Major Depressive Disorder ◽  
Cerebral Blood Flow ◽  
Depressive Disorder ◽  
Regional Cerebral Blood Flow ◽  
Arterial Cannulation ◽  
Regional Cerebral Blood ◽  
Major Depressive
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