scholarly journals Aberrant pattern of regional cerebral blood flow in Alzheimer's disease: a voxel-wise meta-analysis of arterial spin labeling MR imaging studies

Oncotarget ◽  
2017 ◽  
Vol 8 (54) ◽  
pp. 93196-93208 ◽  
Author(s):  
Hai Rong Ma ◽  
Ping Lei Pan ◽  
Li Qin Sheng ◽  
Zhen Yu Dai ◽  
Gen Di Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Mr Imaging ◽  
Arterial Spin Labeling ◽  
Regional Cerebral Blood Flow ◽  
Meta Analysis ◽  
Spin Labeling ◽  
Regional Cerebral Blood ◽  
Imaging Studies

scholarly journals Regional Cerebral Blood Flow in Mild Cognitive Impairment and Alzheimer’s Disease Measured with Arterial Spin Labeling Magnetic Resonance Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Alba Sierra-Marcos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Arterial Spin Labeling ◽  
Regional Cerebral Blood Flow ◽  
Spin Labeling ◽  
Regional Cerebral Blood

Alzheimer’s disease (AD) depicts dynamic changes in regional brain function from early stages of the disease. Arterial spin labeling- (ASL-) based MRI methods have been applied for detecting regional cerebral blood flow (rCBF) perfusion changes in patients with AD and mild cognitive impairment (MCI). Nevertheless, the results obtained from ASL studies in AD and MCI are still controversial, since rCBF maps may show both hypoperfusion or hyperperfusion areas in brain structures involved in different cognitive functions. The goal of this review is to provide the current state of the art regarding the role of ASL for detecting distinctive perfusion patterns in subjects with MCI and/or AD. The ability to obtain this information using a noninvasive and widely available modality such as ASL should greatly enhance the knowledge into the broad range of hemodynamically related changes taking place during the cognitive decline process in AD.

scholarly journals Quantitative Changes in Regional Cerebral Blood Flow Induced by Cold, Heat and Ischemic Pain

2012 ◽  
Vol 117 (4) ◽  
pp. 857-867 ◽  
Author(s):  
Michael A. Frölich ◽  
Hrishikesh Deshpande ◽  
Timothy Ness ◽  
Georg Deutsch
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Regional Cerebral Blood Flow ◽  
Spin Labeling ◽  
Angular Gyrus ◽  
Ischemic Pain ◽  
Regional Cerebral Blood ◽  
Cold Pain ◽  
Area 6

Background The development of arterial spin labeling methods has allowed measuring regional cerebral blood flow (rCBF) quantitatively and to show the pattern of cerebral activity associated with any state such as a sustained pain state or changes due to a neurotropic drug. Methods The authors studied the differential effects of three pain conditions in 10 healthy subjects on a 3 Tesla scanner during resting baseline, heat, cold, and ischemic pain using continuous arterial spin labeling. Results Cold pain showed the greatest absolute rCBF increases in left anterior cingulate cortex, left amygdala, left angular gyrus, and Brodmann area 6, and a significant rCBF decrease in the cerebellum. Changes in rCBF were characteristic of the type of pain condition: cold and heat pain showed increases, whereas the ischemic condition showed a reduction in mean absolute gray matter flow compared with rest. An association of subjects' pain tolerance and cerebral blood flow was noted. Conclusions The observation that quantitative rCBF changes are characteristic of the pain task used and that there is a consistent rCBF change in Brodman area 6, an area responsible for the integration of a motor response to pain, should provide extremely useful information in the quest to develop an imaging biomarker of pain. Conceivably, response in BA6 may serve as an objective measure of analgesic efficacy.

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