scholarly journals Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder

2012 ◽  
Vol 2 (1) ◽  
Author(s):  
Jonathan Savitz ◽  
Allison C. Nugent ◽  
Dara M. Cannon ◽  
Paul J. Carlson ◽  
Rebecca Davis ◽  
...  
Keyword(s):  
Blood Flow ◽  
Major Depressive Disorder ◽  
Cerebral Blood Flow ◽  
Depressive Disorder ◽  
Regional Cerebral Blood Flow ◽  
Arterial Cannulation ◽  
Regional Cerebral Blood ◽  
Major Depressive

scholarly journals Case Report: Changes in Regional Cerebral Blood Flow in Chronic Akathisia of a Depressed Patient Before and After Electroconvulsive Therapy Treatment

2021 ◽  
Vol 12 ◽  
Author(s):  
Akihito Suzuki ◽  
Ryota Kobayashi ◽  
Toshinori Shirata ◽  
Hitomi Komoriya ◽  
Masafumi Kanoto ◽  
...  
Keyword(s):  
Blood Flow ◽  
Major Depressive Disorder ◽  
Cerebral Blood Flow ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Regional Cerebral Blood Flow ◽  
Parietal Lobe ◽  
Regional Cerebral Blood ◽  
Major Depressive ◽  
Before And After

Akathisia, which characterized by subjective restlessness and objective hyperactivity, is induced mostly by antipsychotics and antidepressants. Chronic akathisia is defined as persistence of symptoms for more than 3 months. The pathophysiology of chronic akathisia remains unclear. This report describes a depressed patient, a 66-year-old woman with a diagnosis of major depressive disorder, with chronic akathisia. Her regional cerebral blood flow (rCBF) was measured using single photon emission computed tomography (SPECT) before and after the treatment with electroconvulsive therapy (ECT). She had experienced akathisia-like symptoms three times prior because of risperidone, escitalopram, and clomipramine administration, accompanied by major depression. After levomepromazine was added to quetiapine to treat insomnia, she developed akathisia symptoms such as a sense of restlessness and inability to sit in one place for a few minutes. These antipsychotics were withdrawn. Propranolol was administered, leading to no apparent improvement for 8 months. After she was diagnosed as having major depressive disorder and chronic akathisia, she received 10 sessions of bilateral ECT. Her depressive symptoms improved greatly. Akathisia disappeared completely after ECT. SPECT revealed that rCBF was decreased in the middle frontal gyrus and parietal lobe, that it was increased in the thalamus, fusiform gyrus, and cerebellum before ECT, and that these abnormalities in rCBF were approaching normal levels after ECT. Findings presented in this report suggest ECT as a beneficial treatment for chronic akathisia. Altered rCBF in the middle frontal gyrus, parietal lobe, thalamus, fusiform gyrus, and cerebellum, and especially decreased rCBF in the parietal lobe, may be related to the pathophysiology of chronic akathisia.

Pretreatment Predictors of Early Response Revealed by Quantitative Cerebral Blood Flow in Major Depressive Disorder

2017 ◽  
Vol 41 (S1) ◽  
pp. S225-S225
Author(s):  
Z. Hou ◽  
Z. Wang ◽  
W. Jiang ◽  
Y. Yin ◽  
Y. Yue ◽  
...  
Keyword(s):  
Blood Flow ◽  
Major Depressive Disorder ◽  
Cerebral Blood Flow ◽  
Depressive Disorder ◽  
Early Response ◽  
Middle Frontal Gyrus ◽  
Receiver Operating Curve ◽  
Posterior Lobe ◽  
Major Depressive ◽  
Sensorimotor Network

ObjectiveThe potential pattern of regional cerebral blood flow (rCBF) in major depressive disorder (MDD) underlies different response to antidepressants medication remain unclear. This study aimed to investigate the differences of rCBF between patients with different treatment response.MethodsEighty MDD patients [(44 treatment-responsive depression (RD) and 36 non-responding depression (NRD)] and 42 healthy controls (HC) underwent pulsed arterial spin labeling (PASL) scans in magnetic resonance imaging and clinical estimates. The exact rCBF values of each groups were obtained via quantification evaluation.ResultsCompared to NRD, the RD patients showed decreased rCBF values in frontal sensorimotor network (i.e. left paracentral lobule, left medial frontal gyrus, right superior frontal gyrus and right middle frontal gyrus), and further receiver operating curve (ROC) analyses demonstrated that the altered rCBF in these four regions exhibited outstanding performance on distinguishing NRD from RD. The NRD also exhibited reduced rCBF in bilateral cerebellum posterior lobe and right middle occipital gyrus and elevated rCBF in right postcentral gyrus and right middle frontal gyrus as compared to HC.ConclusionsThe decreased rCBF in frontal sensorimotor network appeared to be distinct characteristics for NRD, and might be severed as promising neuroimaging markers to differentiate depressed patients with weak early response to antidepressant medication. These findings expand our understanding of neural substrate underlying the antidepressant efficacy.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Cerebral blood flow modulations during proactive control in major depressive disorder

2018 ◽  
Vol 133 ◽  
pp. 175-181 ◽  
Author(s):  
Alexandra Hoffmann ◽  
Casandra I. Montoro ◽  
Gustavo A. Reyes del Paso ◽  
Stefan Duschek
Keyword(s):  
Blood Flow ◽  
Major Depressive Disorder ◽  
Cerebral Blood Flow ◽  
Depressive Disorder ◽  
Proactive Control ◽  
Major Depressive

scholarly journals Discovery and replication of cerebral blood flow differences in major depressive disorder

2019 ◽  
Vol 25 (7) ◽  
pp. 1500-1510 ◽  
Author(s):  
Crystal M. Cooper ◽  
Cherise R. Chin Fatt ◽  
Peiying Liu ◽  
Bruce D. Grannemann ◽  
Thomas Carmody ◽  
...  
Keyword(s):  
Blood Flow ◽  
Major Depressive Disorder ◽  
Cerebral Blood Flow ◽  
Depressive Disorder ◽  
Major Depressive
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