A 90-day oral toxicity study of nisin A, an anti-microbial peptide derived from Lactococcus lactis subsp. lactis, in F344 rats

2010 ◽  
Vol 48 (8-9) ◽  
pp. 2421-2428 ◽  
Author(s):  
Akihiro Hagiwara ◽  
Norio Imai ◽  
Hironao Nakashima ◽  
Yosuke Toda ◽  
Mayumi Kawabe ◽  
...  
Keyword(s):  
Lactococcus Lactis ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Lactococcus Lactis Subsp ◽  
F344 Rats

A 90-day oral toxicity study of beta-carotene derived from Blakeslea trispora, a natural food colorant, in F344 rats

2005 ◽  
Vol 43 (7) ◽  
pp. 1127-1133 ◽  
Author(s):  
K. Nabae ◽  
T. Ichihara ◽  
A. Hagiwara ◽  
T. Hirota ◽  
Y. Toda ◽  
...  
Keyword(s):  
Beta Carotene ◽  
Toxicity Study ◽  
Blakeslea Trispora ◽  
Natural Food ◽  
Oral Toxicity ◽  
Food Colorant ◽  
F344 Rats

scholarly journals A 28-day oral toxicity study of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, in F344 rats

2010 ◽  
Vol 35 (3) ◽  
pp. 317-325 ◽  
Author(s):  
Akihiro Hagiwara ◽  
Norio Imai ◽  
Masashi Sano ◽  
Mayumi Kawabe ◽  
Seiko Tamano ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Acetobacter Aceti ◽  
F344 Rats

FOUR-WEEK ORAL TOXICITY STUDY OF 1-CARBOXY-5,7-DIBROMO-6-HYDROXY-2,3,4-TRICHLOROXANTHONE (HXCA), AN IMPURITY OF PHLOXINE B, IN F344 RATS.

2003 ◽  
Vol 28 (5) ◽  
pp. 445-453 ◽  
Author(s):  
Akihiro HAGIWARA ◽  
Masashi SANO ◽  
Toshio ICHIHARA ◽  
Hiroko YOSHINO ◽  
Emiko MIYATA ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
F344 Rats

A 90-day oral toxicity study of purple corn color, a natural food colorant, in F344 rats

2008 ◽  
Vol 46 (2) ◽  
pp. 774-780 ◽  
Author(s):  
Kyoko Nabae ◽  
Shim-mo Hayashi ◽  
Mayumi Kawabe ◽  
Toshio Ichihara ◽  
Akihiro Hagiwara ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Natural Food ◽  
Oral Toxicity ◽  
Food Colorant ◽  
Purple Corn ◽  
F344 Rats

A ninety-day oral toxicity study of a new type of processed gum arabic, from Acacia tree (Acacia senegal) exudates, in F344 rats

2006 ◽  
Vol 44 (4) ◽  
pp. 560-566 ◽  
Author(s):  
Y. Doi ◽  
T. Ichihara ◽  
A. Hagiwara ◽  
N. Imai ◽  
S. Tamano ◽  
...  
Keyword(s):  
Gum Arabic ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Acacia Senegal ◽  
New Type ◽  
F344 Rats ◽  
Acacia Tree

A subchronic oral toxicity study on medical herb extract, KIOM CRC#BP10A, in male and female mice

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
ES Cho ◽  
YJ Lee ◽  
JS Park ◽  
J Kim ◽  
NS Kim ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Male And Female ◽  
Female Mice ◽  
Subchronic Oral Toxicity Study ◽  
Herb Extract

Subchronic 90-day oral toxicity study of Chelidonii herba in pigs

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
P Kosina ◽  
J Drabek ◽  
J Vicar ◽  
J Vostalova ◽  
J Ulrichova ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity

Four-Week Repeated Oral Toxicity Study of Leuconostoc citreum GR1 in Rats

2013 ◽  
Vol 42 (4) ◽  
pp. 600-607 ◽  
Author(s):  
Ah-Ra Kim ◽  
Myung-Yul Lee ◽  
Hae-Choon Chang ◽  
Jae-Joon Lee
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Leuconostoc Citreum

Growth, nisA Gene Expression, and In Situ Activity of Novel Lactococcus lactis subsp. cremoris Costarter Culture in Commercial Hard Cheese Production

2017 ◽  
Vol 80 (12) ◽  
pp. 2137-2146 ◽  
Author(s):  
Dimitrios Noutsopoulos ◽  
Athanasia Kakouri ◽  
Eleftheria Kartezini ◽  
Dimitrios Pappas ◽  
Efstathios Hatziloukas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lactococcus Lactis ◽  
Starter Culture ◽  
Fold Increase ◽  
Raw Milk ◽  
Good Growth ◽  
Lactococcus Lactis Subsp ◽  
Quantitative Expression ◽  
Hard Cheese

ABSTRACT This study evaluated in situ expression of the nisA gene by an indigenous, nisin A–producing (NisA+) Lactococcus lactis subsp. cremoris raw milk genotype, represented by strain M78, in traditional Greek Graviera cheeses under real factory-scale manufacturing and ripening conditions. Cheeses were produced with added a mixed thermophilic and mesophilic commercial starter culture (CSC) or with the CSC plus strain M78 (CSC+M78). Cheeses were sampled after curd cooking (day 0), fermentation of the unsalted molds for 24 h (day 1), brining (day 7), and ripening of the brined molds (14 to 15 kg each) for 30 days in a fully controlled industrial room (16.5°C; 91% relative humidity; day 37). Total RNA was directly extracted from the cheese samples, and the expression of nisA gene was evaluated by real-time reverse transcription PCR (qRT-PCR). Agar overlay and well diffusion bioassays were correspondingly used for in situ detection of the M78 NisA+ colonies in the cheese agar plates and antilisterial activity in whole-cheese slurry samples, respectively. Agar overlay assays showed good growth (>8 log CFU/g of cheese) of the NisA+ strain M78 in coculture with the CSC and vice versa. The nisA expression was detected in CSC+M78 cheese samples only, with its expression levels being the highest (16-fold increase compared with those of the control gene) on day 1, followed by significant reduction on day 7 and almost negligible expression on day 37. Based on the results, certain intrinsic and mainly implicit hurdle factors appeared to reduce growth prevalence rates and decrease nisA gene expression, as well as the nisin A–mediated antilisterial activities of the NisA+ strain M78 postfermentation. To our knowledge, this is the first report on quantitative expression of the nisA gene in a Greek cooked hard cheese during commercial manufacturing and ripening conditions by using a novel, rarely isolated, indigenous NisA+ L. lactis subsp. cremoris genotype as costarter culture.

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