ABVD and BEACOPP regimens’ effects on fertility in young males with Hodgkin lymphoma

Purpose Considering the increased cancer patient survivorship, the focus is now on addressing the impacts of treatment on quality of life. In young people, altered reproductive function is a major issue and its effects in young males are largely neglected by novel research. To improve clinician awareness, we systematically reviewed side effects of chemotherapy for Hodgkin lymphoma (HL) in young males. Methods The review was prospectively registered (PROSPERO N. CRD42019122868). Three databases (Medline via PUBMED, SCOPUS, and Cochrane Library) were searched for studies featuring males aged 13-51-years who underwent chemotherapy for HL using ABVD (Adriamycin® (doxorubicin), bleomycin, vinblastine, and dacarbazine) or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisolone) regimens. These chemotherapy regimens were compared against each other using sperm characteristics, FSH, and inhibin B levels to measure fertility levels. Results Data were extracted from five studies featuring 1344 patients. 6 months post-ABVD saw marked deterioration in sperm count, further reduced by more cycles (P = 0.05). Patients treated with BEACOPP rather than ABVD were more prone to oligospermia. Receiving fewer cycles of both regimens increased the likelihood of sperm production recovering. Patients treated with 6-8 cycles of BEACOPP did not recover spermiogenesis. Conclusions ABVD and BEACOPP regimens significantly reduce fertility function to varying effects depending on treatment duration. ABVD temporarily causes significant reductions in male fertility, whereas BEACOPP’s effects are more permanent. Therefore, clinicians should discuss fertility preservation with male patients receiving infertility-inducing gonadotoxic therapy. Further high-quality studies are required to more adequality describe the risk to fertility by chemotherapy.

Tactics of surgical treatment of hysteromyoma at women with disturbance of genesial function

The objective: to increase efficiency of surgical treatment of hysteromyoma at women of genesial age on the basis of preoperative use medicamental correction. Materials and methods. Сlinical-laboratory and functional examination of 130 women of genesial age was conducted, at 100 from which there was diagnostic hysteromyoma. 1 (main) group was made by 50 women with a hysteromyoma at whom in addition used as preoperative preparation a preparation which contains ulipristalacetat in a dosage of 5 mg per day within 12 weeks. 2 (comparisons) group made also 50 women with a hysteromyoma who received preoperative preparation gestagens. The control group was made by 30 women of similar genesial age without gynecologic pathology. Results. Introduction in clinical practice of preoperative preparation by preparation ulipristalacetat with the subsequent combined operative measure (hystero-laparoscopy) in one stage with applying of endoscopic seams on a wall of a uterus promotes depression of an intraoperative hemorrhage; to decrease to the volume of infusional therapy and early restoration of fertility function of patients. Conclusion. Use of the algorithm improved by us will allow to increase efficiency of treatment of sterility at women with hysteromyoma. Key words: hysteromyoma, sterility, surgical treatment.

Population viewpoint on Hawkes processes

In this paper we focus on a class of linear Hawkes processes with general immigrants. These are counting processes with shot-noise intensity, including self-excited and externally excited patterns. For such processes, we introduce the concept of the age pyramid which evolves according to immigration and births. The virtue of this approach that combines an intensity process definition and a branching representation is that the population age pyramid keeps track of all past events. This is used to compute new distribution properties for a class of Hawkes processes with general immigrants which generalize the popular exponential fertility function. The pathwise construction of the Hawkes process and its underlying population is also given.