A ninety-day oral toxicity study of a new type of processed gum arabic, from Acacia tree (Acacia senegal) exudates, in F344 rats

2006 ◽  
Vol 44 (4) ◽  
pp. 560-566 ◽  
Author(s):  
Y. Doi ◽  
T. Ichihara ◽  
A. Hagiwara ◽  
N. Imai ◽  
S. Tamano ◽  
...  
Keyword(s):  
Gum Arabic ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Acacia Senegal ◽  
New Type ◽  
F344 Rats ◽  
Acacia Tree

A 90-day oral toxicity study of beta-carotene derived from Blakeslea trispora, a natural food colorant, in F344 rats

2005 ◽  
Vol 43 (7) ◽  
pp. 1127-1133 ◽  
Author(s):  
K. Nabae ◽  
T. Ichihara ◽  
A. Hagiwara ◽  
T. Hirota ◽  
Y. Toda ◽  
...  
Keyword(s):  
Beta Carotene ◽  
Toxicity Study ◽  
Blakeslea Trispora ◽  
Natural Food ◽  
Oral Toxicity ◽  
Food Colorant ◽  
F344 Rats

scholarly journals A 28-day oral toxicity study of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, in F344 rats

2010 ◽  
Vol 35 (3) ◽  
pp. 317-325 ◽  
Author(s):  
Akihiro Hagiwara ◽  
Norio Imai ◽  
Masashi Sano ◽  
Mayumi Kawabe ◽  
Seiko Tamano ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Acetobacter Aceti ◽  
F344 Rats

FOUR-WEEK ORAL TOXICITY STUDY OF 1-CARBOXY-5,7-DIBROMO-6-HYDROXY-2,3,4-TRICHLOROXANTHONE (HXCA), AN IMPURITY OF PHLOXINE B, IN F344 RATS.

2003 ◽  
Vol 28 (5) ◽  
pp. 445-453 ◽  
Author(s):  
Akihiro HAGIWARA ◽  
Masashi SANO ◽  
Toshio ICHIHARA ◽  
Hiroko YOSHINO ◽  
Emiko MIYATA ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
F344 Rats

A 90-day oral toxicity study of nisin A, an anti-microbial peptide derived from Lactococcus lactis subsp. lactis, in F344 rats

2010 ◽  
Vol 48 (8-9) ◽  
pp. 2421-2428 ◽  
Author(s):  
Akihiro Hagiwara ◽  
Norio Imai ◽  
Hironao Nakashima ◽  
Yosuke Toda ◽  
Mayumi Kawabe ◽  
...  
Keyword(s):  
Lactococcus Lactis ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Lactococcus Lactis Subsp ◽  
F344 Rats

A 90-day oral toxicity study of purple corn color, a natural food colorant, in F344 rats

2008 ◽  
Vol 46 (2) ◽  
pp. 774-780 ◽  
Author(s):  
Kyoko Nabae ◽  
Shim-mo Hayashi ◽  
Mayumi Kawabe ◽  
Toshio Ichihara ◽  
Akihiro Hagiwara ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Natural Food ◽  
Oral Toxicity ◽  
Food Colorant ◽  
Purple Corn ◽  
F344 Rats

scholarly journals Toxicity and bacterial anti-motility activities of the hydroethanolic extract of Acacia senegal (L.) Willd (Fabaceae) leaves

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
René Dofini Magnini ◽  
Mathieu Nitiéma ◽  
Geoffroy G. Ouédraogo ◽  
Sylvain Ilboudo ◽  
Alimata Bancé ◽  
...  
Keyword(s):  
Body Weight ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Toxicity Study ◽  
Resistant Bacteria ◽  
Cytotoxicity Test ◽  
Significant Activity ◽  
Oral Toxicity ◽  
Acacia Senegal ◽  
Hydroethanolic Extract

Abstract Background Acacia senegal is a plant traditionally used for its various properties, including the treatment of infectious diseases. Recently, our team has demonstrated the ability of the hydroethanolic extract of the leaves to increase the activity of phenicol antibiotics against multi-resistant bacteria. The aim of this work is to determine the toxicological effects of the extract and its capacity to inhibit the bacterial mobility of Gram-negative bacteria, in order to evaluate the level of safety use of this plant. Methods The cytotoxicity test was performed using the neutral red absorption method. Acute and sub-acute oral toxicity were conducted on NMRI mice and Wistar rats. The behaviour and adverse effects were recorded during the 14 days of the acute study. For the subacute test, biochemical parameters, food and water consumption, and morphological parameters were determined. The anti-motility activities were evaluated on Pseudomonas aeruginosa PA01 and Escherichia coli AG100, using specific concentrations of Agar as required by the method. Results HEASG induced inhibition of keratinocytes cell growth with an IC50 of 1302 ± 60 μg/mL. For the acute toxicity study in mice, the single dose of extract of 2000 mg/kg body weight caused no deaths and no behavioural changes were observed; therefore, the median lethal dose (LD50) of HEASG was calculated to 5000 mg/kg body weight. In Wistar rats, no mortality was observed at 250, 500 and 1000 mg/kg/day during the 28-day subacute oral toxicity study. The weights of both females and males increased globally over time, regardless of the batch. No statistically significant differences were registered for organ weights and biochemical parameters, except for chloride for biochemical parameters. Water and food consumption did not change significantly. Furthermore, no macroscopic changes in organ appearance were observed. Regarding anti-motility activity, the extract has reduced the swarming motility of PA01 and AG100 significantly at the concentration of 32 μg/mL (P < 0.001). The extract has reduced the swimming motility (P < 0.01) of PA01 but not AG100. Conclusions The results suggest that hydroethanolic extract of A. senegal leaves has significant activity against bacterial motility and relatively low toxicity.

A subchronic oral toxicity study on medical herb extract, KIOM CRC#BP10A, in male and female mice

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
ES Cho ◽  
YJ Lee ◽  
JS Park ◽  
J Kim ◽  
NS Kim ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Male And Female ◽  
Female Mice ◽  
Subchronic Oral Toxicity Study ◽  
Herb Extract

Subchronic 90-day oral toxicity study of Chelidonii herba in pigs

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
P Kosina ◽  
J Drabek ◽  
J Vicar ◽  
J Vostalova ◽  
J Ulrichova ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity

Four-Week Repeated Oral Toxicity Study of Leuconostoc citreum GR1 in Rats

2013 ◽  
Vol 42 (4) ◽  
pp. 600-607 ◽  
Author(s):  
Ah-Ra Kim ◽  
Myung-Yul Lee ◽  
Hae-Choon Chang ◽  
Jae-Joon Lee
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Leuconostoc Citreum
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