scholarly journals A 28-day oral toxicity study of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, in F344 rats

2010 ◽  
Vol 35 (3) ◽  
pp. 317-325 ◽  
Author(s):  
Akihiro Hagiwara ◽  
Norio Imai ◽  
Masashi Sano ◽  
Mayumi Kawabe ◽  
Seiko Tamano ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Acetobacter Aceti ◽  
F344 Rats

A 90-day oral toxicity study of beta-carotene derived from Blakeslea trispora, a natural food colorant, in F344 rats

2005 ◽  
Vol 43 (7) ◽  
pp. 1127-1133 ◽  
Author(s):  
K. Nabae ◽  
T. Ichihara ◽  
A. Hagiwara ◽  
T. Hirota ◽  
Y. Toda ◽  
...  
Keyword(s):  
Beta Carotene ◽  
Toxicity Study ◽  
Blakeslea Trispora ◽  
Natural Food ◽  
Oral Toxicity ◽  
Food Colorant ◽  
F344 Rats

FOUR-WEEK ORAL TOXICITY STUDY OF 1-CARBOXY-5,7-DIBROMO-6-HYDROXY-2,3,4-TRICHLOROXANTHONE (HXCA), AN IMPURITY OF PHLOXINE B, IN F344 RATS.

2003 ◽  
Vol 28 (5) ◽  
pp. 445-453 ◽  
Author(s):  
Akihiro HAGIWARA ◽  
Masashi SANO ◽  
Toshio ICHIHARA ◽  
Hiroko YOSHINO ◽  
Emiko MIYATA ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
F344 Rats

A 90-day oral toxicity study of nisin A, an anti-microbial peptide derived from Lactococcus lactis subsp. lactis, in F344 rats

2010 ◽  
Vol 48 (8-9) ◽  
pp. 2421-2428 ◽  
Author(s):  
Akihiro Hagiwara ◽  
Norio Imai ◽  
Hironao Nakashima ◽  
Yosuke Toda ◽  
Mayumi Kawabe ◽  
...  
Keyword(s):  
Lactococcus Lactis ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Lactococcus Lactis Subsp ◽  
F344 Rats

A 90-day oral toxicity study of purple corn color, a natural food colorant, in F344 rats

2008 ◽  
Vol 46 (2) ◽  
pp. 774-780 ◽  
Author(s):  
Kyoko Nabae ◽  
Shim-mo Hayashi ◽  
Mayumi Kawabe ◽  
Toshio Ichihara ◽  
Akihiro Hagiwara ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Natural Food ◽  
Oral Toxicity ◽  
Food Colorant ◽  
Purple Corn ◽  
F344 Rats

A ninety-day oral toxicity study of a new type of processed gum arabic, from Acacia tree (Acacia senegal) exudates, in F344 rats

2006 ◽  
Vol 44 (4) ◽  
pp. 560-566 ◽  
Author(s):  
Y. Doi ◽  
T. Ichihara ◽  
A. Hagiwara ◽  
N. Imai ◽  
S. Tamano ◽  
...  
Keyword(s):  
Gum Arabic ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Acacia Senegal ◽  
New Type ◽  
F344 Rats ◽  
Acacia Tree

A subchronic oral toxicity study on medical herb extract, KIOM CRC#BP10A, in male and female mice

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
ES Cho ◽  
YJ Lee ◽  
JS Park ◽  
J Kim ◽  
NS Kim ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Male And Female ◽  
Female Mice ◽  
Subchronic Oral Toxicity Study ◽  
Herb Extract

Subchronic 90-day oral toxicity study of Chelidonii herba in pigs

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
P Kosina ◽  
J Drabek ◽  
J Vicar ◽  
J Vostalova ◽  
J Ulrichova ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity

Four-Week Repeated Oral Toxicity Study of Leuconostoc citreum GR1 in Rats

2013 ◽  
Vol 42 (4) ◽  
pp. 600-607 ◽  
Author(s):  
Ah-Ra Kim ◽  
Myung-Yul Lee ◽  
Hae-Choon Chang ◽  
Jae-Joon Lee
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Leuconostoc Citreum

Acute and subacute toxicity assessment of Madhulai Manappagu (Siddha herbal syrup formulation) in animal model

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Meenakshi Sundaram Malayappan ◽  
Gayathri Natarajan ◽  
Logamanian Mockaiyathevar ◽  
Meenakumari Ramasamy
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Oral Route ◽  
Toxicity Assessment ◽  
Toxicity Study ◽  
Female Rats ◽  
Albino Rats ◽  
Oral Toxicity ◽  
Gross Pathology ◽  
Toxicity Studies

Abstract Objectives Madhulai Manappagu – a well-known sastric and widely prescribed Siddha herbal syrup formulation indicated for treating Veluppu Noi (Anaemia especially Iron deficiency Anaemia) has been in day today practice in Tamil Nadu for a quite longer decades. The syrup is a herbal preparation which has a sweet pleasant odour and a palatable taste, contain the juice of pomegranate (Punica granatum L.) as the main ingredient. Though the formulation is a fruit juice, the safety profile of the syrup is not established and is being marketed without toxicological evaluation. The study is aimed at ascertaining the acute and sub-acute toxicity assessment of Madhulai Manappagu in Wistar Albino rats. Methods The acute and sub-acute (28day repeated oral) toxicity studies were performed as per the guidelines mentioned in the Organization for Economic Cooperation and Development (OECD) 423 (adopted on December 2001) and TG 407 (adopted on October 2008) with slight modifications respectively. For acute toxicity study, three female rats were randomly selected as control; three female rats were randomly selected and were administered a single dose of 5,000 mg/kg body weight per oral route. For sub-acute (28day repeated oral) toxicity studies, three doses of test drug MM of 500 mg/kg/day (low dose), 750 mg/kg/day (intermittent dose) and 1,000 mg/kg/day (high dose) were selected for administration. Both sexes of Wistar Albino rats were randomized into four groups of 10 animals each (five males, five females). Group I was kept as control group. Group II, III and IV served as low, intermittent and high doses of MM respectively. Animals were observed for mortality, morbidity, body weight changes, feed and water intake. Haematology, clinical biochemistry, electrolytes, gross pathology, relative organ weight and histopathological examination were performed. Results In the acute toxicity study, rats showed no toxicological signs on behavior, gross pathology and body weight of rats when treated with a single dose of 5,000 mg/kg body weight per oral route. In the subacute (28 days repeated oral) toxicity study, rats have showed no significant changes on behavior, gross pathology, body weight, and hematological and biochemical parameters when treated with Madhulai Manappagu in three different doses. Conclusions The toxicity studies which include both acute and 28 days repeated (subacute) oral toxicity studies, revealed no observed adverse effect level (NOAEL) of Madhulai Manappagu in animals. Thus the safety of the drug in human usage was ensured.

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