Plasma lipopolysaccharide-binding protein levels in neonatal early-onset bacterial infection

2008 ◽  
Vol 84 ◽  
pp. S70
Author(s):  
Anna Blazejczak ◽  
Ryszard Czajka ◽  
Jacek Rudnicki ◽  
Agnieszka Kordek ◽  
Beata Loniewska
Keyword(s):  
Bacterial Infection ◽  
Early Onset ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Protein Levels ◽  
Lipopolysaccharide Binding

scholarly journals Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection

2006 ◽  
Vol 26 (2) ◽  
pp. 115-119 ◽  
Author(s):  
T W Orlikowsky ◽  
C Trüg ◽  
F Neunhoeffer ◽  
M Deperschmidt ◽  
M Eichner ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Early Onset ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Lipopolysaccharide Binding

Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection

Nature ◽  
10.1038/39622 ◽  
1997 ◽  
Vol 389 (6652) ◽  
pp. 742-745 ◽  
Author(s):  
Robert S. Jack ◽  
Xiaolong Fan ◽  
Martin Bernheiden ◽  
Gabriele Rune ◽  
Monika Ehlers ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Gram Negative ◽  
Lipopolysaccharide Binding

High Lipopolysaccharide Binding Protein Levels are Related to Intermediate Mortality in Patients with Decompensated Cirrhosis

2016 ◽  
Vol 64 (2) ◽  
pp. S247-S248
Author(s):  
D. Agiasotelli ◽  
A. Alexopoulou ◽  
L. Vasilieva ◽  
E. Hadziyannis ◽  
D. Goukos ◽  
...  
Keyword(s):  
Binding Protein ◽  
Decompensated Cirrhosis ◽  
Lipopolysaccharide Binding Protein ◽  
Protein Levels ◽  
Lipopolysaccharide Binding

scholarly journals Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis

PLoS ONE ◽  
2009 ◽  
Vol 4 (8) ◽  
pp. e6818 ◽  
Author(s):  
Jesús Villar ◽  
Lina Pérez-Méndez ◽  
Elena Espinosa ◽  
Carlos Flores ◽  
Jesús Blanco ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Lung Injury ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Protein Levels ◽  
Lipopolysaccharide Binding

Lipopolysaccharide and lipopolysaccharide-binding protein levels and their relationship to early metabolic improvement after bariatric surgery

2015 ◽  
Vol 11 (4) ◽  
pp. 933-939 ◽  
Author(s):  
Mercedes Clemente-Postigo ◽  
Maria del Mar Roca-Rodriguez ◽  
Antonio Camargo ◽  
Luis Ocaña-Wilhelmi ◽  
Fernando Cardona ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Protein Levels ◽  
Lipopolysaccharide Binding

scholarly journals Elevated Levels of Lipopolysaccharide-Binding Protein and Soluble CD14 in Plasma in Neonatal Early-Onset Sepsis

2002 ◽  
Vol 9 (2) ◽  
pp. 440-445 ◽  
Author(s):  
Reinhard Berner ◽  
Birgitt Fürll ◽  
Felix Stelter ◽  
Jana Dröse ◽  
Hans-Peter Müller ◽  
...  
Keyword(s):  
Cord Blood ◽  
Plasma Levels ◽  
Early Onset ◽  
Binding Protein ◽  
Control Group ◽  
Lipopolysaccharide Binding Protein ◽  
Soluble Cd14 ◽  
Early Onset Sepsis ◽  
Cytokine Plasma ◽  
Lipopolysaccharide Binding

ABSTRACT No data on lipopolysaccharide-binding protein (LBP) in newborns with sepsis have been available up to now. We therefore determined levels of LBP and soluble CD14 (sCD14) in plasma of healthy and septic neonates in order to evaluate their potential diagnostic role. The study included prospectively collected patient samples of two recently published studies on cytokine expression in neonatal sepsis. Twenty-nine septic patients were enrolled in the present analysis. Samples—either cord blood or peripheral blood—from patients admitted within the first 24 h of life for suspicion of sepsis and cord blood samples of a control group of 40 healthy mature infants delivered spontaneously were analyzed. For seven patients of the septic group, a second sample collected between 24 and 48 h of life was available. Levels of sCD14 and LBP in plasma were determined by an enzyme immunoassay using recombinant CD14 and LBP as standards. LBP and sCD14 were correlated to cytokine plasma levels. In septic neonates, LBP (median, 36.6 versus 7.8 μg/ml; P < 0.001) and sCD14 (median, 0.42 versus 0.28 μg/ml; P < 0.001) levels were highly elevated when compared to those of healthy neonates and strongly correlated to granulocyte colony-stimulating factor (G-CSF), interleukin-1β (IL-1β), IL-6, and IL-8 levels. LBP levels in septic neonates analyzed between 24 and 48 h of life even increased when compared to samples obtained at or shortly after delivery (median, 36.6 versus 60 μg/ml; P = 0.038). In summary, levels of LBP in plasma of neonates with early-onset sepsis are significantly elevated; the elevated plasma levels seem to persist for more than 24 h, which could provide the clinician with a prolonged time period to identify the newborn with bacterial sepsis.

Sign in / Sign up

Export Citation Format

Share Document