Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection

Nature ◽  
10.1038/39622 ◽  
1997 ◽  
Vol 389 (6652) ◽  
pp. 742-745 ◽  
Author(s):  
Robert S. Jack ◽  
Xiaolong Fan ◽  
Martin Bernheiden ◽  
Gabriele Rune ◽  
Monika Ehlers ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Gram Negative ◽  
Lipopolysaccharide Binding

scholarly journals Critical Role of Lipopolysaccharide-Binding Protein and CD14 in Immune Responses against Gram-Negative Bacteria

2001 ◽  
Vol 167 (5) ◽  
pp. 2759-2765 ◽  
Author(s):  
Didier Le Roy ◽  
Franco Di Padova ◽  
Yoshiyuki Adachi ◽  
Michel Pierre Glauser ◽  
Thierry Calandra ◽  
...  
Keyword(s):  
Immune Responses ◽  
Binding Protein ◽  
Critical Role ◽  
Gram Negative Bacteria ◽  
Lipopolysaccharide Binding Protein ◽  
Gram Negative ◽  
Lipopolysaccharide Binding

scholarly journals Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation

Blood ◽  
2008 ◽  
Vol 111 (4) ◽  
pp. 2462-2469 ◽  
Author(s):  
Jason W. Chien ◽  
Michael J. Boeckh ◽  
John A. Hansen ◽  
Joan G. Clark
Keyword(s):  
Genetic Variation ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Binding Protein ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Lipopolysaccharide Binding Protein ◽  
Gram Negative ◽  
Basal Serum ◽  
Lipopolysaccharide Binding

Lipopolysaccharide binding protein (LBP) function is dependent on circulating LBP levels. Disturbance of LBP transcription regulation may influence the risk for clinical events. In a nested case-control study using a single nucleotide polymorphism haplotype tagging (tagSNP) approach, we assessed whether genetic variation in the LBP gene influences the risk for Gram-negative (GN) bacteremia after allogeneic hematopoietic cell transplantation (HCT), then validated the association in a prospective cohort by correlating genetic variation with basal serum LBP levels and mortality. Presence of the tagSNP 6878 C allele among patients was associated with a 2-fold higher risk for GN bacteremia (odds ratio = 2.15; 95% confidence interval [CI], 1.31-3.52, P = .002). TagSNP 6878 was in strong linkage disequilibrium with 3 SNPs in the LBP promoter, one of which was SNP 1683 (r2 = 0.8), located in a CAAT box that regulates LBP promoter efficiency. SNP 1683 was associated with higher median basal serum LBP levels (TT 8.07 μg/mL; TC 10.40 μg/mL; CC 17.39 μg/mL; P = .002), and a 5-fold increase in GN bacteremia related mortality after HCT (hazard ratio = 4.83; 95% CI, 1.38-16.75, P = .013). These data suggest that transcriptional regulation of the LBP gene contributes to the risk for developing GN bacteremia and death after HCT.

Plasma lipopolysaccharide-binding protein levels in neonatal early-onset bacterial infection

2008 ◽  
Vol 84 ◽  
pp. S70
Author(s):  
Anna Blazejczak ◽  
Ryszard Czajka ◽  
Jacek Rudnicki ◽  
Agnieszka Kordek ◽  
Beata Loniewska
Keyword(s):  
Bacterial Infection ◽  
Early Onset ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Protein Levels ◽  
Lipopolysaccharide Binding

Lipopolysaccharide-binding protein: a possible diagnostic marker for Gram-negative bacteremia in neutropenic cancer patients

2003 ◽  
Vol 29 (12) ◽  
pp. 2157-2161 ◽  
Author(s):  
Claudi S. M. Oude Nijhuis ◽  
Edo Vellenga ◽  
Simon M. G. J. Daenen ◽  
Winette T. A. van der Graaf ◽  
Jourik A. Gietema ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Diagnostic Marker ◽  
Binding Protein ◽  
Protein A ◽  
Lipopolysaccharide Binding Protein ◽  
Gram Negative ◽  
Gram Negative Bacteremia ◽  
Lipopolysaccharide Binding

scholarly journals Influence of Lipopolysaccharide-Binding Protein on Pulmonary Inflammation in Gram-Negative Pneumonia

Shock ◽  
2015 ◽  
Vol 43 (6) ◽  
pp. 612-619 ◽  
Author(s):  
Michael A. Taddonio ◽  
Vladislav Dolgachev ◽  
Markus Bosmann ◽  
Peter A. Ward ◽  
Grace Su ◽  
...  
Keyword(s):  
Binding Protein ◽  
Pulmonary Inflammation ◽  
Lipopolysaccharide Binding Protein ◽  
Gram Negative ◽  
Lipopolysaccharide Binding
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