Obstetric and perinatal outcomes of expectant management and immediate induction of labour in term premature rupture of membranes: promising outcomes from expectant management cohort

Background: Premature rupture of membranes (PROM) is common obstetric entity, the management even at term is controversial and there is no consensus for definite protocol of management. Objective of the present study is to compare the effectiveness, safety of expectant management of 24 hours and immediate induction with PGE2 gel in terms of maternal and fetal outcome in term PROM.Methods: 200 women were randomized to group A expectant management and group B immediate induction, after strict Inclusion and exclusion criteria. In expectant group waiting period was 24 hours. Multiple end points were examined throughout management. Chi square test and independent t tests were performed for statistical analysis. P value<0.05 was considered significant.Results: Demographic parameters of patients, maternal and gestational age were similar in both groups. Primigravidae were more in both groups A and B. Vaginal delivery rate is more in expectant group and Caesarean Section rate is high in immediate induction group. CS rate was 37% and 23% in group A and B respectively; the difference is statistically significant (p value=0.031). ‘ROM to delivery interval’ was more in group A (16.31±8.67 hrs and 13.85±5.46 hrs) (p value=0.0256). Hospital stay was comparatively more in group A (5.40±0.81 days and 4.11±0.86 days) (p value=0.435). Infective morbidity of mother and baby was low in both groups and no difference was seen.Conclusions: An expectant management allows a good number of women to go into labour and deliver vaginally without an increase in CS rate and infectious morbidity for mother and fetus.

Second Trimester Fetal Loss Due to Citrobacter koseri Infection: A Rare Cause of Preterm Premature Rupture of Membranes (PPROM)

Citrobacter koseri is a facultative anaerobic, motile, non-spore-forming Gram-negative bacillus, which belongs to the family of Enterobacteriaceae. Severe infections due to Citrobacter spp. have been reported in the urinary tract, respiratory airways, intra-abdominal organs, skin and soft tissue, eye, bone, bloodstream, and central nervous system. In newborns, C. koseri is a well-known cause of meningitis, cerebral abscesses, brain adhesions, encephalitis, and pneumocephalus. Infection can be acquired through vertical maternal transmission or horizontal hospital settings; however, in many cases, the source is unknown. Preterm premature rupture of membranes (PPROM), caused by C. koseri, has rarely been described. Herein, we describe a case of PPROM at 16 weeks and 3 days of gestation, leading to anhydramnios. The parents opted for legal termination of the pregnancy, as the prognosis was very poor. C. koseri was isolated postmortem from a placental subamniotic swab and parenchymal sample, as well as fetal blood and lung. To the best of our knowledge, this is the first case of early second-trimester PPROM in which C. koseri infection was demonstrated.

HUBUNGAN KETUBAN PECAH DINI DENGAN KEJADIAN ASFIKSIA LITERATURE REVIEW: THE CORRELATION OF PREMATURE RUPTURE OF MEMBRANES (PROM) WITH THE INCIDENCE OF ASPHYXIA

Menurut Human Development Report tahun 2010 Ketuban Pecah Dini (KPD) di Indonesia berkisar 4,4-7,6% dari seluruh kehamilan dengan KPD berkisar antara 3-18% yang terjadi pada kehamilan preterm, sedangkan pada kehamilan aterm sekitar 8-10%. Menurut beberapa peneliti KPD dapat menyebabkan terjadinya asfiksia. Penelitian ini bertujuan untuk mengetahui hubungan ketuban pecah dini dengan kejadian asfiksia. Jenis penelitian yang digunakan adalah kepustakaan atau kajian literatur. Data penelitian ini berasal dari data sekunder, yaitu berasal dari beberapa sumber penelitian yang terdiri dari 25 sumber yang terdiri dari 7 jurnal ilmiah, 3 jurnal internasional, 5 skripsi/tesis, dan 10 buku. Pencarian sumber menggunakan google scholar, microsoft academic, media meneliti, and google. Dari penelitian ini didapatkan bahwa penyebab terjadinya asfiksia yang disebabkan oleh faktor langsung maupun faktor tidak langsung. Faktor langsung tersebut adalah KPD itu sendiri. Sedangkan, untuk faktor yang tidak langsung adalah CPD dan usia kehamilan. Sehingga asfiksia yang disebabkan kedua faktor tersebut dapat memperburuk keadaan terjadinya asfiksia. Dari salah satu penelitian dalam negeri oleh peneliti Anisa di daerah Kediri didapatkan angka kejadian asfiksia sebanyak 53% oleh ibu yang mengalami KPD. Berdasarkan hasil penelitian dari dalam negeri dan luar negeri dengan rata-rata p value ?0,005, sehingga didapatkan kesimpulan terdapat hubungan antara ketuban pecah dini dengan kejadian asfiksia.

Neonatal Outcomes In Women With Preterm Premature Rupture of Membranes At Periviable Gestational Age

Purpose: To examine the outcomes of preterm infants born to women with preterm premature rupture of membranes at periviable gestational age.Methods: This is a retrospective study analyzing data on singleton deliveries complicated by prolonged premature rupture of membranes occurring before 24 weeks of gestation. Neonatal outcomes including birth weight, Apgar score, retinopathy of prematurity, intraventricular hemorrhage, bronchopulmonary dysplasia, necrotizing enterocolitis, hearing impairment and mortality were evaluated.Results: Ninety four preterm infants who were born after a prolonged premature rupture of membranes of at least 7 days were included in the study.Median gestational week at onset of membrane rupture was 27.1 ± 4.2 weeks (range 17 - 33) and median latency period in days was 16 ± 21.8 (range 7 - 105). We found that the survival rate to discharge within neonates born after prolonged rupture of membrane at gestational week less than 24 weeks is 79.2%. These neonates did not show an increased rate of major morbidities compared to neonates born following membrane rupture at gestational week 24 to 27. Conclusion: We described a high survival rate without major morbidities following prolonged preterm membrane rupture before viability.

Deep Infiltrating Endometriosis and Adenomyosis: Implications on Pregnancy and Outcome

Endometriosis (EM), especially deep infiltrating endometriosis (DIE) and adenomyosis (AM), are known to cause pain and sterility in young women. More recently, they have also been described as risk factors for obstetric complications. While the pathophysiology is not yet completely understood, they seem to share a common origin: archimetrosis. Methods: A systematic literature review was conducted to summarize the existing evidence on DIE and AM as risk factors for obstetric complications. Results: Preterm birth, caesarean section delivery (CS) and placental abnormalities are associated with the diagnosis of DIE and AM. Women with AM seem to experience more often hypertensive pregnancy disorders, premature rupture of membranes and their children are born with lower birth weights than in the control groups. However, many of the studies tried to evaluate AM, EM and DIE as separate risk factors. Moreover, often they did not adjust for important confounders such as multiple pregnancies, parity, mode of conception and maternal age. Therefore, prospective studies with larger numbers of cases and appropriate adjustment for confounders are needed to explore the pathophysiology and to prove causality.