scholarly journals Wnt Signaling Inhibitors Regulate the Transcriptional Response to Morphogenetic Shh-Gli Signaling in the Neural Tube

2006 ◽  
Vol 11 (3) ◽  
pp. 325-337 ◽  
Author(s):  
Qiubo Lei ◽  
Yongsu Jeong ◽  
Kamana Misra ◽  
Shike Li ◽  
Alice K. Zelman ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Neural Tube ◽  
Transcriptional Response ◽  
Signaling Inhibitors

scholarly journals Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities

genesis ◽  
2021 ◽  
Author(s):  
Alexandra J. Palmer ◽  
Dawn Savery ◽  
Valentina Massa ◽  
Andrew J. Copp ◽  
Nicholas D. E. Greene
Keyword(s):  
Wnt Signaling ◽  
Neural Crest ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Genetic Interaction ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

Catalytic Asymmetric Synthesis of Mixed 3,3′-Bisindoles and Their Evaluation as Wnt Signaling Inhibitors

2013 ◽  
Vol 125 (9) ◽  
pp. 2546-2550 ◽  
Author(s):  
Takayoshi Arai ◽  
Yushi Yamamoto ◽  
Atsuko Awata ◽  
Kentaro Kamiya ◽  
Masami Ishibashi ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Asymmetric Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Signaling Inhibitors ◽  
Catalytic Asymmetric

scholarly journals Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis

2017 ◽  
Vol 4 (4) ◽  
pp. 160913 ◽  
Author(s):  
Nicoletta Carucci ◽  
Emanuele Cacci ◽  
Paola S. Nisi ◽  
Valerio Licursi ◽  
Yu-Lee Paul ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Development ◽  
Transcriptional Response ◽  
Neural Tissue ◽  
Positional Information ◽  
Multiple Roles ◽  
Chromatin Activation ◽  
Neural Stem Progenitor Cells ◽  
Rostrocaudal Axis

During vertebrate neural development, positional information is largely specified by extracellular morphogens. Their distribution, however, is very dynamic due to the multiple roles played by the same signals in the developing and adult neural tissue. This suggests that neural progenitors are able to modify their competence to respond to morphogen signalling and autonomously maintain positional identities after their initial specification. In this work, we take advantage of in vitro culture systems of mouse neural stem/progenitor cells (NSPCs) to show that NSPCs isolated from rostral or caudal regions of the mouse neural tube are differentially responsive to retinoic acid (RA), a pivotal morphogen for the specification of posterior neural fates. Hoxb genes are among the best known RA direct targets in the neural tissue, yet we found that RA could promote their transcription only in caudal but not in rostral NSPCs. Correlating with these effects, key RA-responsive regulatory regions in the Hoxb cluster displayed opposite enrichment of activating or repressing histone marks in rostral and caudal NSPCs. Finally, RA was able to strengthen Hoxb chromatin activation in caudal NSPCs, but was ineffective on the repressed Hoxb chromatin of rostral NSPCs. These results suggest that the response of NSPCs to morphogen signalling across the rostrocaudal axis of the neural tube may be gated by the epigenetic configuration of target patterning genes, allowing long-term maintenance of intrinsic positional values in spite of continuously changing extrinsic signals.

scholarly journals Draxin acts as a molecular rheostat of canonical Wnt signaling to control cranial neural crest EMT

2018 ◽  
Vol 217 (10) ◽  
pp. 3683-3697 ◽  
Author(s):  
Erica J. Hutchins ◽  
Marianne E. Bronner
Keyword(s):  
Wnt Signaling ◽  
Neural Crest ◽  
Neural Tube ◽  
Epithelial To Mesenchymal Transition ◽  
Cranial Neural Crest ◽  
Canonical Wnt Signaling ◽  
Mesenchymal Transition ◽  
Molecular Rheostat ◽  
Timing Of Initiation ◽  
Canonical Wnt

Neural crest cells undergo a spatiotemporally regulated epithelial-to-mesenchymal transition (EMT) that proceeds head to tailward to exit from the neural tube. In this study, we show that the secreted molecule Draxin is expressed in a transient rostrocaudal wave that mirrors this emigration pattern, initiating after neural crest specification and being down-regulated just before delamination. Functional experiments reveal that Draxin regulates the timing of cranial neural crest EMT by transiently inhibiting canonical Wnt signaling. Ectopic maintenance of Draxin in the cranial neural tube blocks full EMT; while cells delaminate, they fail to become mesenchymal and migratory. Loss of Draxin results in premature delamination but also in failure to mesenchymalize. These results suggest that a pulse of intermediate Wnt signaling triggers EMT and is necessary for its completion. Taken together, these data show that transient secreted Draxin mediates proper levels of canonical Wnt signaling required to regulate the precise timing of initiation and completion of cranial neural crest EMT.

Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system

2016 ◽  
Vol 108 ◽  
pp. 154-165 ◽  
Author(s):  
Zhixiang Xu ◽  
Jiajun Li ◽  
Yiyuan Wu ◽  
Zhijian Sun ◽  
Lusong Luo ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Ring System ◽  
Design Synthesis ◽  
Signaling Inhibitors

Genetic studies ofANKRD6as a molecular switch between Wnt signaling pathways in human neural tube defects

2014 ◽  
Vol 103 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Redouane Allache ◽  
Mingqin Wang ◽  
Patrizia De Marco ◽  
Elisa Merello ◽  
Valeria Capra ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathways ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Molecular Switch ◽  
Genetic Studies

scholarly journals Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone

Development ◽  
2011 ◽  
Vol 138 (17) ◽  
pp. 3859-3859 ◽  
Author(s):  
C. van de Ven ◽  
M. Bialecka ◽  
R. Neijts ◽  
T. Young ◽  
J. E. Rowland ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Neural Tube ◽  
Hox Genes ◽  
Growth Zone ◽  
Posterior Growth Zone
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