Genetic studies ofANKRD6as a molecular switch between Wnt signaling pathways in human neural tube defects

2014 ◽  
Vol 103 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Redouane Allache ◽  
Mingqin Wang ◽  
Patrizia De Marco ◽  
Elisa Merello ◽  
Valeria Capra ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathways ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Molecular Switch ◽  
Genetic Studies

scholarly journals Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities

genesis ◽  
2021 ◽  
Author(s):  
Alexandra J. Palmer ◽  
Dawn Savery ◽  
Valentina Massa ◽  
Andrew J. Copp ◽  
Nicholas D. E. Greene
Keyword(s):  
Wnt Signaling ◽  
Neural Crest ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Genetic Interaction ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

Genetic Studies in Neural Tube Defects

2000 ◽  
Vol 32 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Elizabeth C. Melvin ◽  
Timothy M. George ◽  
Gordon Worley ◽  
Amy Franklin ◽  
Joanne Mackey ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Genetic Studies

scholarly journals Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

2005 ◽  
Vol 37 (5) ◽  
pp. 537-543 ◽  
Author(s):  
Matias Simons ◽  
Joachim Gloy ◽  
Athina Ganner ◽  
Axel Bullerkotte ◽  
Mikhail Bashkurov ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathways ◽  
Gene Product ◽  
Molecular Switch ◽  
Type Ii

Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects

2017 ◽  
Vol 110 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Zhiwen Shi ◽  
Xueyan Yang ◽  
Bin-Bin Li ◽  
Shuxia Chen ◽  
Luming Yang ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Novel Mutation ◽  
Chinese Han Population ◽  
Canonical Wnt Signaling ◽  
Chinese Han ◽  
Han Population ◽  
Canonical Wnt

scholarly journals Early Head Specification in Xenopus laevis

2003 ◽  
Vol 3 ◽  
pp. 655-676
Author(s):  
Blue B. Lake ◽  
Kenneth R. Kao
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathways ◽  
Neural Tube ◽  
Intracellular Signaling ◽  
Organizer Region ◽  
Dorsal Side ◽  
Bmp Signaling ◽  
The Body ◽  
Normal Brain ◽  
Sequence Of Events

The head represents the most dorsal and anterior extent of the body axis. InXenopus, the progressive determination of the head is an extremely complex process involving the activation and localized antagonism of a number of interdependent intracellular signaling pathways including the Wingless/Int-1 (Wnt), bone morphogenetic protein (BMP), and nodal-related pathways. The sequence of events that specify the head are: dorsal-ventral polarization and head organizer specification in the blastula; gastrulation; neural induction; and patterning of the anterior-posterior and dorsal-ventral neuraxes. Wnt signaling is required for the specification of the dorsal side initially but is then inhibited within the organizer once it has formed. Similarly, Wnt signaling is required along the length of the neural tube, but must be suppressed at its rostral end for normal brain development. Nodal signaling is also necessary for induction of the mesendoderm, but is subsequently suppressed in its dorsal-anterior extreme to specify head organizer. BMP signaling is required for ventral mesoderm and non-neural ectoderm, and must also be suppressed in the head organizer region and for the differentiation of the ventral midline of the neural tube. Thus, development of the head, and indeed the body plan in general, requires precisely timed and spatially restricted activation and repression of these signaling pathways.

Lessons from dolutegravir and neural tube defects

2021 ◽  
Vol 8 (1) ◽  
pp. e3-e4
Author(s):  
Elaine Abrams ◽  
Landon Myer
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects

A Public Health Success Story: Folic Acid Fortification and Supplementation for Prevention of Neural Tube Defects

2004 ◽  
Author(s):  
Linda Longerich ◽  
Roy West ◽  
Ed Randell ◽  
Marian Crowley ◽  
Shiliang Liu ◽  
...  
Keyword(s):  
Public Health ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Success Story ◽  
Folic Acid Fortification
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