scholarly journals Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors

Oncotarget ◽  
2015 ◽  
Vol 6 (21) ◽  
pp. 18518-18533 ◽  
Author(s):  
Meriam Ayadi ◽  
Anaïs Bouygues ◽  
Djamila Ouaret ◽  
Nathalie Ferrand ◽  
Salem Chouaib ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Beta Catenin ◽  
Clinical Use ◽  
Colorectal Cancer Cells ◽  
Signaling Inhibitors

scholarly journals P4HA1 regulates human colorectal cancer cells through HIF1α‑mediated Wnt signaling

2020 ◽  
Vol 21 (2) ◽  
Author(s):  
Qiang Zhang ◽  
Yue Yin ◽  
Hongye Zhao ◽  
Yan Shi ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

Abstract 1588: Canonical Wnt signaling mediates resistance of colorectal cancer cells to radiation therapy.

2013 ◽  
Author(s):  
Georg Emons ◽  
Janneke Möller ◽  
Melanie Spitzner ◽  
Emil Kendziorra ◽  
Jochen Gaedcke ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Radiation Therapy ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Canonical Wnt Signaling ◽  
Colorectal Cancer Cells ◽  
Canonical Wnt

scholarly journals A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells

2015 ◽  
Vol 13 (6) ◽  
pp. 969-981 ◽  
Author(s):  
Jing Song ◽  
Zhanwen Du ◽  
Mate Ravasz ◽  
Bohan Dong ◽  
Zhenghe Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Protein Interaction ◽  
Colorectal Cancer Cells

scholarly journals The Notch-2 Gene Is Regulated by Wnt Signaling in Cultured Colorectal Cancer Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e17957 ◽  
Author(s):  
Jonas Ungerbäck ◽  
Nils Elander ◽  
John Grünberg ◽  
Mikael Sigvardsson ◽  
Peter Söderkvist
Keyword(s):  
Colorectal Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Colorectal Cancer Cells

scholarly journals Activation of Tumor-Specific Splice Variant Rac1b by Dishevelled Promotes Canonical Wnt Signaling and Decreased Adhesion of Colorectal Cancer Cells

2007 ◽  
Vol 67 (6) ◽  
pp. 2469-2479 ◽  
Author(s):  
Susmita Esufali ◽  
George S. Charames ◽  
Vaijayanti V. Pethe ◽  
Pinella Buongiorno ◽  
Bharati Bapat
Keyword(s):  
Colorectal Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Splice Variant ◽  
Canonical Wnt Signaling ◽  
Colorectal Cancer Cells ◽  
Canonical Wnt

scholarly journals TCF7L2 Silencing Reprograms the 4D Nucleome of Colorectal Cancer Cells

2020 ◽  
Author(s):  
Markus A. Brown ◽  
Gabrielle A. Dotson ◽  
Scott Ronquist ◽  
Georg Emons ◽  
Indika Rajapakse ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Time Series ◽  
Stem Cell ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Rna Sequencing ◽  
Chromatin Structure ◽  
Cell Phenotype ◽  
Colorectal Cancer Cells

AbstractCanonical Wnt signaling is crucial for intestinal homeostasis as the major Wnt signaling effector in the intestines, TCF4, is required for stem cell maintenance. The capability of TCF4 to maintain the stem cell phenotype is contingent upon β-catenin, a potent transcriptional activator which interacts with histone acetyltransferases and chromatin remodeling complexes. In colorectal cancer, mutations result in high levels of nuclear β-catenin causing aberrant cell growth. Here, we used RNAi to explore the influence of TCF4 on chromatin structure (Hi-C) and gene expression (RNA sequencing) across a 72-hour time series in colorectal cancer. We found that TCF4 reduction results in a disproportionate upregulation of gene expression genome-wide, including a powerful induction of SOX2. Hi-C analysis revealed a general increase in chromatin compaction across the entire time series, though this did not influence gene expression. Analysis of local chromosome organization demonstrated a TAD boundary loss which influenced the expression of a cluster of CEACAM genes on chromosome 19. Four-dimensional nucleome (4DN) analysis, which integrates structural (Hi-C) and functional (RNA sequencing) data, identified EMT and E2F as the two most deregulated pathways and LUM, TMPO, and AURKA as highly influential genes in these networks. Results from gene expression, chromatin structure, and centrality analyses were then integrated to generate a list of candidate transcription factors for reprogramming of colorectal cancer cells to a vulnerable state. The top ranked transcription factor in our analysis was c-JUN, an oncoprotein known to interact with TCF4 and β-catenin.

Selenoprotein P (SELENOP) as a WNT Signaling Modulator in Colorectal Cancer Cells

2020 ◽  
Vol 159 ◽  
pp. S60
Author(s):  
Jennifer Pilat ◽  
Sarah Short ◽  
Victoria Ng ◽  
Ethan Lee ◽  
Christopher Williams
Keyword(s):  
Colorectal Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Selenoprotein P ◽  
Colorectal Cancer Cells
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