scholarly journals Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities

genesis ◽  
2021 ◽  
Author(s):  
Alexandra J. Palmer ◽  
Dawn Savery ◽  
Valentina Massa ◽  
Andrew J. Copp ◽  
Nicholas D. E. Greene
Keyword(s):  
Wnt Signaling ◽  
Neural Crest ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Genetic Interaction ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

scholarly journals Draxin acts as a molecular rheostat of canonical Wnt signaling to control cranial neural crest EMT

2018 ◽  
Vol 217 (10) ◽  
pp. 3683-3697 ◽  
Author(s):  
Erica J. Hutchins ◽  
Marianne E. Bronner
Keyword(s):  
Wnt Signaling ◽  
Neural Crest ◽  
Neural Tube ◽  
Epithelial To Mesenchymal Transition ◽  
Cranial Neural Crest ◽  
Canonical Wnt Signaling ◽  
Mesenchymal Transition ◽  
Molecular Rheostat ◽  
Timing Of Initiation ◽  
Canonical Wnt

Neural crest cells undergo a spatiotemporally regulated epithelial-to-mesenchymal transition (EMT) that proceeds head to tailward to exit from the neural tube. In this study, we show that the secreted molecule Draxin is expressed in a transient rostrocaudal wave that mirrors this emigration pattern, initiating after neural crest specification and being down-regulated just before delamination. Functional experiments reveal that Draxin regulates the timing of cranial neural crest EMT by transiently inhibiting canonical Wnt signaling. Ectopic maintenance of Draxin in the cranial neural tube blocks full EMT; while cells delaminate, they fail to become mesenchymal and migratory. Loss of Draxin results in premature delamination but also in failure to mesenchymalize. These results suggest that a pulse of intermediate Wnt signaling triggers EMT and is necessary for its completion. Taken together, these data show that transient secreted Draxin mediates proper levels of canonical Wnt signaling required to regulate the precise timing of initiation and completion of cranial neural crest EMT.

Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects

2017 ◽  
Vol 110 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Zhiwen Shi ◽  
Xueyan Yang ◽  
Bin-Bin Li ◽  
Shuxia Chen ◽  
Luming Yang ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Novel Mutation ◽  
Chinese Han Population ◽  
Canonical Wnt Signaling ◽  
Chinese Han ◽  
Han Population ◽  
Canonical Wnt

scholarly journals Enhanced Activation of Canonical Wnt Signaling Confers Mesoderm-Derived Parietal Bone with Similar Osteogenic and Skeletal Healing Capacity to Neural Crest-Derived Frontal Bone

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0138059 ◽  
Author(s):  
Shuli Li ◽  
Natalina Quarto ◽  
Kshemendra Senarath-Yapa ◽  
Nathaniel Grey ◽  
Xue Bai ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Neural Crest ◽  
Parietal Bone ◽  
Frontal Bone ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

scholarly journals Caudal-related Homeobox (Cdx) Protein-dependent Integration of Canonical Wnt Signaling on Paired-box 3 (Pax3) Neural Crest Enhancer

2012 ◽  
Vol 287 (20) ◽  
pp. 16623-16635 ◽  
Author(s):  
Oraly Sanchez- Ferras ◽  
Baptiste Coutaud ◽  
Taraneh Djavanbakht Samani ◽  
Isabelle Tremblay ◽  
Ouliana Souchkova ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Neural Crest ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

scholarly journals Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure

EBioMedicine ◽  
2015 ◽  
Vol 2 (6) ◽  
pp. 513-527 ◽  
Author(s):  
Chiharu Kimura-Yoshida ◽  
Kyoko Mochida ◽  
Kristina Ellwanger ◽  
Christof Niehrs ◽  
Isao Matsuo
Keyword(s):  
Wnt Signaling ◽  
Neural Tube ◽  
Neural Plate ◽  
Neural Tube Closure ◽  
Canonical Wnt Signaling ◽  
Fate Specification ◽  
Neural Plate Border ◽  
Canonical Wnt ◽  
Tube Closure

scholarly journals A new transgenic reporter line reveals Wnt-dependent Snail2 reexpression and cranial neural crest differentiation in Xenopus

2019 ◽  
Author(s):  
Jiejing Li ◽  
Mark Perfetto ◽  
Christopher Materna ◽  
Rebecca Li ◽  
Hong Thi Tran ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Neural Crest ◽  
Fluorescent Protein ◽  
Developmental Stages ◽  
Egfp Expression ◽  
Cranial Neural Crest ◽  
Canonical Wnt Signaling ◽  
Reporter Line ◽  
Green Fluorescent ◽  
Canonical Wnt

AbstractDuring vertebrate embryogenesis, the cranial neural crest (CNC) forms at the neural plate border and subsequently migrates and differentiates into many types of cells. The transcription factor Snail2, which is induced by canonical Wnt signaling to be expressed in the early CNC, is pivotal for CNC induction and migration in Xenopus. However, snail2 expression is silenced during CNC migration, and its roles at later developmental stages remain unclear. We generated a transgenic X. tropicalis line that expresses enhanced green fluorescent protein (eGFP) driven by the snail2 promoter/enhancer, and observed eGFP expression not only in the pre-migratory and migrating CNC, but also the differentiating CNC. This transgenic line can be used directly to detect deficiencies in CNC development at various stages, including subtle perturbation of CNC differentiation. In situ hybridization and immunohistochemistry confirm that Snail2 is reexpressed in the differentiating CNC. Using a separate transgenic Wnt reporter line, we show that canonical Wnt signaling is also active in the differentiating CNC. Blocking Wnt signaling shortly after CNC migration causes reduced snail2 expression and impaired differentiation of CNC-derived head cartilage structures. These results suggest that Wnt signaling drives the reexpression of snail2 in the post-migratory CNC and regulates CNC differentiation.

A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration

2011 ◽  
Vol 124 (15) ◽  
pp. e1-e1 ◽  
Author(s):  
S. Banerjee ◽  
L. Gordon ◽  
T. M. Donn ◽  
C. Berti ◽  
C. B. Moens ◽  
...  
Keyword(s):  
Cell Migration ◽  
Wnt Signaling ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Canonical Wnt Signaling ◽  
Neural Crest Cell Migration ◽  
Canonical Wnt ◽  
Crest Cell
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